TY - JOUR AU - Kumada, Kazuki AU - Yasuda, Jun PY - 2018 TI - Evolutionary acquired robustness and vulnerability in cancer genome: negligible negative selection in carcinogenesis JF - Translational Cancer Research; Vol 7, Supplement 4 (April 26, 2018): Translational Cancer Research Y2 - 2018 KW - N2 - Cancer is a disease involving the accumulation of somatic genetic alterations accompanied by clonal evolution (1,2). A wide range of oncogenes and tumor suppressor genes are known to be mutated, deleted, rearranged, and/or amplified in most cancers. These genes have been identified by functional analyses (transformation of NIH3T3), genetic linkage analyses, and structural genomic analyses such as cytogenetics. UR - https://tcr.amegroups.org/article/view/19879