TY - JOUR AU - Yan, Hui-Xian AU - Du, Jin AU - Fu, Jing AU - Huang, Wei AU - Jia, Li-Meng AU - Ping, Pang AU - Zhao, Ling AU - Song, Ye-Qiong AU - Jia, Xiao-Meng AU - Dou, Jing-Tao AU - Mu, Yi-Ming AU - Wang, Fu-Lin AU - Tian, Wen AU - Lyu, Zhao-Hui PY - 2019 TI - Microarray-based differential expression profiling of long noncoding RNAs and messenger RNAs in formalin-fixed paraffin-embedded human papillary thyroid carcinoma samples JF - Translational Cancer Research; Vol 8, No 2 (April 30, 2019): Translational Cancer Research Y2 - 2019 KW - N2 - Background: Long noncoding RNAs (lncRNAs) can regulate the expression of genes at almost every level. The altered expression of lncRNAs was observed in many kinds of cancers. Until recently, few studies have focused on the function of lncRNAs in the context of papillary thyroid carcinoma (PTC). Methods: In the current study, we collected seven PTC and nodular goiter tissue samples and explored mRNA and lncRNA expression patterns in these samples by microarray. Results: We observed aberrant expression of 94 lncRNAs and 99 mRNAs in the seven PTC samples as compared to the nodular goiter tissue [fold change (FC) ≥2.0; P Conclusions: In the present study a string of novel lncRNAs associated with PTC were identified. Further study of these lncRNAs should be performed to identify novel target molecules which may improve diagnosis and treatment of PTC. UR - https://tcr.amegroups.org/article/view/27752