TY - JOUR AU - Esposito, Emanuela AU - Avino, Franca AU - di Giacomo, Raimondo AU - Donzelli, Ivana AU - Marone, Ugo AU - Melucci, Maria Teresa AU - Rinaldo, Chiara AU - Ruffolo, Fulvio AU - Saponara, Ruggero AU - Siani, Claudio AU - Tortoriello, Raffaele AU - Botti, Gerardo AU - Rinaldo, Massimo AU - Fucito, Alfredo PY - 2019 TI - Angiosarcoma of the breast, the unknown—a review of the current literature JF - Translational Cancer Research; Vol 8, Supplement 5 (October 24, 2019): Translational Cancer Research ( Rare Tumors of the Breast) Y2 - 2019 KW - N2 - Angiosarcoma of the breast is one of the rarest malignancies. Breast angiosarcoma can be classified into primary when arising de novo and secondary to chronic lymphoedema or breast irradiation. Molecular pathways involved in angiosarcoma development have not been described clearly, yet some gene point mutations and protein altered expression levels have been detected. So far, their management is based above all on surgery. Hence, further studies starting from the few known key points may help to develop more effective strategies based both on target therapies, together with surgery. UR - https://tcr.amegroups.org/article/view/30432