%0 Journal Article %T Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies %A Couture, Olivier %A Foley, Jessica %A Kassell, Neal F. %A Larrat, Benoit %A Aubry, Jean-Francois %J Translational Cancer Research %D 2014 %B 2014 %9 %! Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies %K %X Therapeutic ultrasound has been used to thermally ablate solid tumors since the 90s, and a variety of cancers are presently being treated clinically, taking advantage of ultrasound- or MR-imaging guidance and monitoring. However, an ever-increasing body of preclinical literature demonstrates how ultrasound can achieve bioeffects beyond thermal ablation, including non-invasive drug delivery to target cancer cells. In this review, we will provide a summary of in vivo ultrasound-based strategies shown to deliver drug payloads to tumor environments, to enhance permeability of vessel walls and cell membranes, and to activate drugs and genes in situ . %U https://tcr.amegroups.org/article/view/3354 %V 3 %N 5 %P 494-511 %@ 2219-6803