TY - JOUR AU - Chen, Jiaxuan AU - Haller, Carolyn A. AU - Chaikof, Elliot L. PY - 2016 TI - Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1 JF - Translational Cancer Research; Vol 5, Supplement 4 (October 31, 2016): Translational Cancer Research Y2 - 2016 KW - N2 - P-selectin glycoprotein ligand-1 (PSGL-1) is a major selectin ligand expressed by hematopoietic cells and well known for its role in mediating leukocyte trafficking into inflamed tissue. A recent report by Tinoco et al . examines chronic viral infection and melanoma in PSGL-1 deficient mice ( Selplg −/− ) and suggests a previously unknown and selectin-independent function for PSGL-1 as an immune checkpoint regulator that promotes T cell exhaustion (1). UR - https://tcr.amegroups.org/article/view/9964