NLRC3 mediated PI3K-mTOR inhibition takes a toll on colon cancer

NLRs (nucleotide-binding domain and leucine-rich repeats containing receptors) are pattern recognition receptors, evolutionarily conserved across plants and animals (1). NLRs, initiate immune response against specific damage and pathogen-associated molecular patterns (DAMPs/PAMPs) (2). NLRs also contribute to the function and regulation of multiple innate immune signaling pathways (3) (Figure 1). NLRC3, the newly characterized NLR family member is preferentially expressed in immune cells. NLRC3 performs various innate immune functions such as regulation of several inflammatory signaling pathways (4).