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TCR 2020 Annual Report

Greetings from Editor-in-Chief and Editorial Office of Translational Cancer Research!

We are pleased to share the 2020 Annual Report of Translational Cancer Research here. 2020 has seen much progress for TCR. We hope 2021 will bring greater things to TCR. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2021.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2021!

Endometrial Cancer

The articles published in this special series can be considered a significant step forward in our knowledge about endometrial cancer and stimulate further discussion among the readers. In particular, the novel pieces of information contained in these articles may lead to important changes in the clinical practice and potential paradigm shifts in the future management of endometrial cancer.

Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

The series on tumor immune microenvironment in cancer progression and cancer therapy includes articles analyzing the role of microenvironmental acidity and TEs, the immune cells such as MDSCs, and genetic factors such as miRNAs. The TME has profound impacts on cancer progression and remodeling of the TME has become a strategy to facilitate cancer therapy.

Urothelial Carcinoma

The editors wanted to introduce an interesting and varied topic of UC and would like to thank prominent researchers of bladder cancer around the world who participated in this topic.

Loco-regional Therapy for Metastatic Breast Cancer

Patients with MBC can survive longer without metastatic symptoms when treated with these systemic therapies. However, MBC cannot be cured with ICI or other treatments and the majority of MBC patients will die of their disease. It is important to use all available treatments to obtain maximal control of symptoms, prevent serious complications, and prolong life with minimal disruption of daily activities and quality of life. We endeavor to use fewer powerful drugs, such as hormone therapy and oral agents, and thereby minimize severe adverse events.

New Impact Factor for Translational Cancer Research: 0.986

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2019 citation year: 0.986.

Energy Balance, Aging, Obesity, and Cancer

This issue of TCR features a series of articles on the impact of obesity, diabetes, and cancer in the older adult population, focuses on providing a better understanding of the processes noted above, how they may influence cancer promotion and progression, and how they may be mitigated to reduce cancer incidence and its comorbidities.

Clinic and Therapeutic Potential of Non-coding RNAs in Cancer (Ongoing)

This focused series on “Clinic and Therapeutic Potential of Non-coding RNAs in Cancer” is edited by Alfons Navarro, Human Anatomy and Embryology Unit, Faculty of Medicine and Health Sciences, University of Barcelona, Spain; Joan J. Castellano, Molecular Oncology and Embryology Lab, Faculty of Medicine and Health Sciences, University of Barcelona, Spain; and Marina Díaz-Beyá, Department of Hematology, Hospital Clinic of Barcelona, IDIBAPS, Spain.

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Vol 9, No 12 (December, 2020)

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Announcement more

TCR 2020 Annual Report

Greetings from Editor-in-Chief and Editorial Office of Translational Cancer Research! More >>

New Impact Factor for Translational Cancer Research: 0.986

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2019 citation year: 0.986. More >>

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others),... More >>

Editorial

Factors to be considered in designing frameworks for automated bioinformatics pipelines—a perspective based on application setting

Yuan-Mao Hung, Liang-Chuan Lai

PDF Pages: 7382-7383 Full Text COI Form Open Access

Original Article

ypT0 gastric carcinoma after preoperative chemotherapy: a unique status according to AJCC 8^th edition cancer staging system

Kankai Zhu, Hailong Jin, Qing Zhang, Chunhui Shou, Fang Chen, Jiren Yu

PDF Pages: 7384-7393 Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

WSB2 as a target of Hedgehog signaling promoted the malignant biological behavior of Xuanwei lung cancer through regulating Wnt/β-catenin signaling

Xueqiang Wei, Jun Liao, Yujie Lei, Minjie Li, Guangqiang Zhao, Yongchun Zhou, Lianhua Ye, Yunchao Huang

PDF Pages: 7394-7404 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Effect of the solution-focused brief therapy on cancer-related fatigue in breast cancer patients under adjuvant chemotherapy: a randomized trial

Weimin Liu, Haimei Geng, Lan Ma, Fang Liu, Xia Wei, Xuechun Tian, Lihui Liu

PDF Pages: 7405-7414 Full Text Reporting ChecklistR Data Sharing Statement COI Form Open Access

The expression and prognostic value of RNA binding proteins in clear cell renal cell carcinoma

Can-Xuan Li, Jie Chen, Zheng-Guang Xu, Wing-Keung Yiu, Yen-Ting Lin

PDF Pages: 7415-7431 Full Text Reporting Checklist COI Form Open Access

Identification of potential microRNAs in glioblastoma using bioinformatic analysis and prognostic evaluation

Zhenwei Sun, Yongquan Zhao, Xuan Ding, Deguang Xing, Chengwei Wang, Xiaofei Wang

PDF Pages: 7432-7439 Full Text Reporting Checklist COI Form Open Access

ANXA3 is upregulated by hypoxia-inducible factor 1-alpha and promotes colon cancer growth

Kunli Du, Jiahui Ren, Zhongxue Fu, Xingye Wu, Jianyong Zheng, Xing Li

PDF Pages: 7440-7449 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Negative lymph node count is an independent prognostic factor for female patients with node positive breast cancer

Hao Wu, Yajing Huang

PDF Pages: 7450-7457 Full Text Reporting Checklist COI Form Open Access

Non-target genetic manipulation induces rhabdomyosarcoma in KrasPten-driven mouse model of ovarian cancer

Huiling Lai, Yunyun Guo, Weipeng He, Tingting Sun, Linglong Ouyang, Liming Tian, Yuanyuan Li, Xiaohui Li, Zeshan You, Guofen Yang

PDF Pages: 7458-7468 Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Focus on patients with early esophageal cancer—a prognostic nomogram

Zhiyuan Cheng, Zifan Zhang, Han Lin, Qianqian Meng, Lei Xin, Tianjiao Wang, Wei Wang, Luowei Wang

PDF Pages: 7469-7478 Full Text COI Form Open Access

Level of mesothelin expression can indicate the prognosis of malignant pleural mesothelioma

Feifei Feng, Huanan Zhang, Ying Zhang, Hui Wang

PDF Pages: 7479-7485 Full Text COI Form Open Access

Identification of adriamycin resistance genes in breast cancer based on microarray data analysis

Yan Chen, Yingfeng Lin, Zhaolei Cui

PDF Pages: 7486-7494 Full Text COI Form Open Access

Bioinformatics analysis of microenvironment-related genes associated with radioresistance in glioblastoma

Yun Liu, Yufei Zhao, Jinmei Fang, Jing Fang, Xiaodong Yuan

PDF Pages: 7495-7504 Full Text Reporting Checklist Peer Review File COI Form Open Access

A six-long noncoding RNA model predicts prognosis in lung adenocarcinoma

Yuquan Bai, Senyi Deng

PDF Pages: 7505-7518 Full Text Reporting Checklist Peer Review File COI Form Open Access

Overexpression of acid-sensing ion channel 1a (ASIC1a) promotes breast cancer cell proliferation, migration and invasion

Chao Yang, Zhen Zhu, Xueyan Ouyang, Ruihua Yu, Jiawei Wang, Gang Ding, Feng Jiang

PDF Pages: 7519-7530 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Microenvironment-related prognostic genes in esophageal cancer

Min-Hang Zhou, Xin-Kun Wang

PDF Pages: 7531-7539 Full Text Reporting Checklist COI Form Open Access

AT-rich interactive domain1A determines sensitivity to oxaliplatin in gastric cancer cells

Qing Liu, Qing-Qing Weng, Song-Fei Shen, Tao Jiang, Zhang-Chi Pan, Meng-Xin Lin, Yan-Qin Lan, Yao Wang, Qiang Chen, Chun-Mei Shi

PDF Pages: 7540-7549 Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

The natural extract degalactotigonin exerts antitumor effects on renal cell carcinoma cells through repressing YAP

Yuning Wang, Tianyu Hong, Linbao Chen, Chuanmin Chu, Jiangbo Zhu, Jing Zhang, Chao Wang, Jingcun Zheng, Ning Jiang, Xingang Cui

PDF Pages: 7550-7561 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Druggable driver gene alterations in redefined large cell carcinoma in Chinese patients: an observational study

Jinhua Yang, Yuping Li, Benting Ma, Huikang Xie, Linsong Chen, Xuejuan Gao, Wenxin He

PDF Pages: 7562-7571 Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Non-SMC condensin I complex subunit H (NCAPH), a regulator of cell cycle, predicts poor prognosis in lung adenocarcinoma patients: a study mainly based on TCGA and GEO database

Wei Zhou, Jia Hu, Jun Zhao

PDF Pages: 7572-7587 Full Text Reporting Checklist COI Form Open Access

HPV16 E6 regulates the proliferation, invasion, and apoptosis of cervical cancer cells by downregulating miR-504

Lina Zhang, Yiqing Lai, Yangyang Sun, Baozhen Xu, Xian Qiang, Xiaoli Zhou, Ting Wang

PDF Pages: 7588-7595 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Honokiol inhibits the growth of SKBR3 cells

He Shi, Yange Wang, Mengli Yao, Dian Zhang, Wenli Fang, Ting Zhou, Delu Gan, Shujun Yue, Husun Qian, Tingmei Chen

PDF Pages: 7596-7604 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

A comprehensive assessment of the prognostic role of cell adhesion molecules in acute myeloid leukemia

Jing Cheng, Juan Han, Chunyan Lin

PDF Pages: 7605-7618 Full Text Reporting Checklist COI Form Open Access

Review Article

Functions of polyphenols and its anticancer properties in biomedical research: a narrative review

Pritam Bhagwan Bhosale, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Seong Min Kim, Gon Sup Kim

PDF Pages: 7619-7631 Full Text Reporting Checklist Peer Review File COI Form Open Access

Research progress of circular RNA in digestive tract tumors: a narrative review

Haojia Wang, Yanghui Xiang, Rui Hu, Rui Ji, Yuping Wang

PDF Pages: 7632-7641 Full Text Reporting Checklist COI Form Open Access

Research progress on radiotherapy technology and dose fraction scheme for advanced gliomas

Yu Zhang, Junjie Wang

PDF Pages: 7642-7651 Full Text COI Form Open Access

Case Report

Primary pancreatic cystadenocarcinoma with ovarian metastases in a 38-year-old female: case report

Shun-Da Wang, Meng-Hua Dai, Yu-Pei Zhao

PDF Pages: 7652-7656 Full Text Reporting Checklist COI Form Open Access

Rare diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: one case report and literature review

Yonghui Wu, Kai Zhang, Weibin Wu, Xiaojun Li, Jian Zhang, Huiguo Chen

PDF Pages: 7657-7661 Full Text Reporting Checklist COI Form Open Access

Radiotherapy in COVID-19 patient affected by multiple myeloma: a case report

Marco Krengli, Debora Beldì, Eleonora Ferrara, Micol Zannetti, Federico Mastroleo, Lorenzo De Paoli, Mariangela Greco, Erica Matino, Mario Pirisi, Gianluca Gaidano

PDF Pages: 7662-7668 Full Text Reporting Checklist COI Form Open Access

Long disease-free survival (48 months) in a breast cancer patient with ovarian and pelvic metastasis—a case report

Yu Feng, Xia Zhao, Shuzhen Lv, Bingjun Xiong, Yanping Li, Man Zhang

PDF Pages: 7669-7675 Full Text Reporting Checklist Peer Review File COI Form Open Access

Rare case of a male breast tumour secondary to poorly differentiated rectal adenocarcinoma

Xia Cheng, Tong Zhao, Jia-Ning Jiang, Ying Liu, Heming Li, Ruo-Yu Wang

PDF Pages: 7676-7681 Full Text Reporting Checklist COI Form Open Access

Editorial Commentary

Leveraging well-annotated databases for deep learning in biomedical research

Nam Nhut Phan, Amrita Chattopadhyay, Tzu-Pin Lu, Mong-Hsun Tsai

PDF Pages: 7682-7684 Full Text COI Form Open Access

Editorial on Endometrial Cancer¹

Management of endometrial cancer: current insights and future directions

Antonio Simone Laganà

PDF Pages: 7685-7687 Full Text COI Form Open Access

Original Article on Endometrial Cancer

The significance of plasma D-dimer level in predicting high risk factors of endometrial cancer

Yu-Jia Huang, Bi-Lan Li

PDF Pages: 7688-7696 Full Text COI Form Open Access

Impact of endometrial sampling technique and biopsy volume on the diagnostic accuracy of endometrial cancer

Federico Ferrari, Sara Forte, Giulia Arrigoni, Laura Ardighieri, Maria Consuelo Coppola, Federica Salinaro, Fabio Barra, Enrico Sartori, Franco Odicino

PDF Pages: 7697-7705 Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Endometrial cancer: a genetic point of view

Bianca Bianco, Caio Parente Barbosa, Camila Martins Trevisan, Antonio Simone Laganà, Erik Montagna

PDF Pages: 7706-7715 Full Text Reporting Checklist COI Form Open Access

Review Article on Endometrial Cancer¹

Current role of Pipelle endometrial sampling in early diagnosis of endometrial cancer

Milan Milosav Terzic, Gulzhanat Aimagambetova, Sanja Terzic, Melanie Norton, Gauri Bapayeva, Simone Garzon

PDF Pages: 7716-7724 Full Text COI Form Open Access

Sentinel lymph node biopsy in endometrial cancer: state of the art

Luigi Della Corte, Pierluigi Giampaolino, Antonio Mercorio, Gaetano Riemma, Antonio Schiattarella, Pasquale De Franciscis, Giuseppe Bifulco

PDF Pages: 7725-7733 Full Text COI Form Open Access

Endometrial cancer—is our knowledge changing?

Milena Králíčková, Vaclav Vetvicka, Antonio Simone Laganà

PDF Pages: 7734-7745 Full Text COI Form Open Access

Preoperative assessment of endometrial cancer

Péter Török, Zoárd Krasznai, Szabolcs Molnár, Rudolf Lampé, Attila Jakab

PDF Pages: 7746-7758 Full Text COI Form Open Access

Role of uterine manipulator during laparoscopic endometrial cancer treatment

Vito Andrea Capozzi, Andrea Rosati, Stefano Uccella, Gaetano Riemma, Mattia Tarascio, Marco Torella, Pasquale De Franciscis, Nicola Colacurci, Stefano Cianci

PDF Pages: 7759-7766 Full Text COI Form Open Access

Hysteroscopy in the management of endometrial hyperplasia and cancer in reproductive aged women: new developments and current perspectives

Salvatore Giovanni Vitale, Gaetano Riemma, Jose Carugno, Benito Chiofalo, George Angelos Vilos, Stefano Cianci, Mehmet Sukru Budak, Bernardo Portugal Lasmar, Antonio Raffone, Ilker Kahramanoglu

PDF Pages: 7767-7777 Full Text COI Form Open Access

Lymph node evaluation in endometrial cancer: how did it change over the last two decades?

Ciro Pinelli, Valeria Artuso, Giorgio Bogani, Antonio Simone Laganà, Fabio Ghezzi, Jvan Casarin

PDF Pages: 7778-7784 Full Text COI Form Open Access

Accuracy of preoperative sampling diagnosis for predicting final pathology in patients with endometrial carcinoma: a review

David Lukanović, Miha Matjašič, Borut Kobal

PDF Pages: 7785-7796 Full Text COI Form Open Access

Fertility issue in early stage endometrial cancer patients

Hasan Onur Topçu, Cihan Kaya, Engin Oral

PDF Pages: 7797-7808 Full Text COI Form Open Access

Erratum

Erratum to the prognosis analysis of RFWD2 inhibiting the expression of ETV1 in colorectal cancer

Wei Huang, Xiumei Tian, Xiaoying Guan

PDF Pages: 7809 Full Text Open Access

Disclosure:

1. The series “Endometrial Cancer” was commissioned by the editorial office, Translational Cancer Research without any sponsorship or funding. Antonio Simone Laganà served as the unpaid Guest Editor for the series.

Editorial

Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected

Juan Iovanna, Maria Cecilia Mallmann

The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial

Ian Wong, Simon Law

Immunotherapy in endometrial cancer: who are the most appropriate patients?

Katherine C. Kurnit, Amir A. Jazaeri

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review

Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors

Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen

Common applications of next-generation sequencing technologies in genomic research

Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Magnetic resonance imaging of pancreatic malignancy

Mellena D. Bridges

EGFR and HER2: is there a role in ovarian cancer?

Eleonora Teplinsky, Franco Muggia

Advances on immunotherapy in breast cancer

Kanthi Athreya, Sonia Ali

Targeting the folate receptor for the treatment of ovarian cancer

Robert J. Lutz

Computational resources for radiomics

Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis

Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Mini-Review

The emerging role of chemokine receptor CXCR2 in cancer progression

Tanweer Jaffer, Daqing Ma

Original Article

Impact of image preprocessing on the volume dependence and prognostic potential of radiomics features in non-small cell lung cancer

Xenia Fave, Lifei Zhang, Jinzhong Yang, Dennis Mackin, Peter Balter, Daniel Gomez, David Followill, A. Kyle Jones, Francesco Stingo, Laurence Court

Review Article

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

Liquid biopsy for cancer screening, patient stratification and monitoring

Graham Brock, Elena Castellanos-Rizaldos, Lan Hu, Christine Coticchia, Johan Skog

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Review Articles

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Radiosensitization by gold nanoparticles: effective at megavoltage energies and potential role of oxidative stress

Karl T. Butterworth, Stephen J. McMahon, Laura E. Taggart, Kevin M. Prise

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Biological basis of IORT

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara

Editorial

Focusing in on radiation induced brain injury

M. Kerry O’Banion

Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic

Naomi Lomeli, Daniela A. Bota

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright

Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy

Kebin Liu, Chunwan Lu

New light on the pancreatic cyst conundrum

Nathan A. Berger

HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?

Andrew J. Scott, John C. Wilkinson

(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas

Leland G. Richardson, Bryan D. Choi, William T. Curry

On the subventricular zone origin of human glioblastoma

Akshitkumar M. Mistry

Are lung adenocarcinoma mutations shaping the immune microenvironment?

Philippe Rochigneux, Edward B. Garon

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors

Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa

Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4

Nan Ding, Qianzheng Zhu

Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?

Apar Gupta, Nisha Ohri, Bruce G. Haffty

Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents

Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi

CRISPR-based genetic interaction maps inform therapeutic strategies in cancer

Poornima Ramkumar, Martin Kampmann

Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study

Melin J. Khandekar, Rakesh Jain

The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin

Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed

Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Joanne P. Young, Timothy J. Price, Susan Parry

Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang

Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes

Theresa L. Whiteside

TIC10/ONC201—a potential therapeutic in glioblastoma

Georg Karpel-Massler, Markus D. Siegelin

IDH mutational status and the immune system in gliomas: a tale of two tumors?

Bryan D. Choi, William T. Curry

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry

When better still might not be good enough

Waldemar Debinski

Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy

Vincent C. O. Njar

Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28

Leonardo Chicaybam, Prasad S. Adusumilli

Exosome mediated phenotypic changes in lung cancer pathophysiology

Yoshihisa Shimada, John D. Minna

Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma

Aaron D. DeWard, Rebecca J. Critchley-Thorne

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein

Felicia L. Lenzo, William G. Cance

New incriminating evidence against IGF2

Wen Ding, Lina A. Shehadeh

Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect

Paul Grippo, Ajay V. Maker

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M. Selwan, Aimee L. Edinger

RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver

Satomi Yamamoto, Tomoo Iwakuma

Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy

Michael J. Baine, Chi Lin

Rogue one: another faction of the Wnt empire implicated in assisting GBM progression

Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed

Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano

Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems

Li Tian, Ashley Chang, Marites P. Melancon

IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm

James P. White

Low-frequency ultrasound may improve drug penetration in colonic mucosa

Qiubing Chen, Bo Xiao, Didier Merlin

Dividing and conquering the variation among variants in EML4-ALK lung cancer

Trever G. Bivona

Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu, Huidong Shi

KDM1 links nuclear GSK3β to epigenetic alterations

Weijie Guo, Binhua P. Zhou

Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas

Leland G. Richardson, Bryan D. Choi, William T. Curry

Are lung adenocarcinoma mutations shaping the immune microenvironment?

Philippe Rochigneux, Edward B. Garon

On the subventricular zone origin of human glioblastoma

Akshitkumar M. Mistry

Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy

Kebin Liu, Chunwan Lu

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors

Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data

Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Statistical strategies for microRNAseq batch effect reduction

Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr

Defining functional changes in the brain caused by targeted stereotaxic radiosurgery

Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli

A chain reaction approach to modelling gene pathways

Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes

Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA

Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li

Identification of cancer mechanisms through computational systems modeling

Zhen Qi, Eberhard O. Voit

Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases

Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy

A recursively partitioned mixture model for clustering time-course gene expression data

Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines

Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma

Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer

Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park

How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis

Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao

Alcohol intake patterns for cancer and non-cancer individuals: a population study

Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng

Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial

Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma

Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Review Article

Integrative clustering methods for high-dimensional molecular data

Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley

Sparse principal component analysis in cancer research

Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen

An improved understanding of cancer genomics through massively parallel sequencing

Jamie K. Teer

Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications

Louis Dubeau

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

The promise and challenge of ovarian cancer models

Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Role of the androgen signaling axis in genitourinary malignancies

Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer

Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management

Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas

Exosomal lncRNAs as new players in cell-to-cell communication

Mihnea Dragomir, Baoqing Chen, George A. Calin

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Souparno Bhattacharya, Aroumougame Asaithamby

Translational research in radiation-induced DNA damage signaling and repair

Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue

Genetically engineered mouse models for studying radiation biology

Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch

Renal cell carcinoma: the search for a reliable biomarker

Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer

Advances on immunotherapy in genitourinary and renal cell carcinoma

Gregory P. Botta, Eric Granowicz, Carrie Costantini

The role of novel immunotherapies in non-Hodgkin lymphoma

Allyson Pishko, Sunita D. Nasta

MDMX under stress: the MDMX-MDM2 complex as stress signals hub

Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan

Do p53 stress responses impact organismal aging?

Paul Hasty, Judith Campisi, Z. Dave Sharp

Pharmacological targeting of mutant p53

Samuel Kogan, Darren Carpizo

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

Michael I. Carr, Stephen N. Jones

Regulation of cytotoxic T-cell responses by p53 in cancer

Mitchell W. Braun, Tomoo Iwakuma

The IGF-1R/AKT pathway determines cell fate in response to p53

Lei Duan, Carl G. Maki

Intra molecular interactions in the regulation of p53 pathway

Jiandong Chen

TP53 mutations in epithelial ovarian cancer

Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi, Jin Zhang, Xinbin Chen

Radiomics in head and neck cancer: from exploration to application

Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies

Wei Lu, Wengen Chen

The emerging field of radiomics in esophageal cancer: current evidence and future potential

Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin

Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire

Jung H. Suh, Julie D. Saba

Computational methods and opportunities for phosphorylation network medicine

Yian Ann Chen, Steven A. Eschrich

Role of the androgen signaling axis in genitourinary malignancies

Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report

Miliary brain metastases from lung adenocarcinoma as non- enhancing lesions on MRI: a case report and literature review

Zhenchao Huang, Dan Xie, Ping Yang, En’peng Song, Jinhua Zhang, Jianning Chen, Feng Qin

Neuroendocrine tumor of thoracic spine: case report and literature review

Huiquan Gao, Yanzhen Wan, Hongxia Ma, Tao Huang, Wei Song

Pulmonary benign metastasizing leiomyoma simultaneously diagnosed with uterine leiomyoma at first visit before hysteromyomectomy

Yue Wu, Liwen Fan, Yuxu Niu, Yun Wu, Wen Gao

Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Li Ge, Shan Wang, Hongrui Liu, Xiaohua Shi, Juhong Shi, Ruie Feng

An unresectable gastric cancer with bulky lymph node metastases treated with SOX chemotherapy plus apatinib followed by D3 radical gastrectomy: a case report

Nannan Zhang, Jingyu Deng, Yan Sun, Jianyu Xiao, Hongli Li, Han Liang

Disease progression and pseudoprogression following partial response with rare gingiva metastasis upon IBI308 (sintilimab) immunotherapy reflects the complexity of metastatic lung cancer: a case report

Haiping Jiang, Zhenguang Chen, Yuan Gao, Yongfeng Ding, Qihan You, Lei Ye, Lifeng Li, Guifeng Liu, Lele Song, Nong Xu

Editorial

Radiation and immunotherapy: united as one in the fight against cancer

Arya Amini, Tyler Robin

Original Article

Effects of IFN-γ on the proliferation of 32D cells expressing Akt after IRF-1 gene silencing

Ying Lin, Rongdong Zhang, Shenghua Jiang, Wei Lu, Zenghua Lin, Hong Liu

Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell

Heming Li, Zhi Wang, Shanshan Liang, Qiuge Liu, Piao Wang, Longyu Cai, Ruoyu Wang

Co-expression of VEGF-C and survivin predicts poor prognosis in esophageal squamous cell carcinoma

Yun-Zhu Zeng, Yong-Qu Zhang, Xue-Qiong Lin, Jiong-Yu Chen, Fan Zhang, Jian-Ling Zhu, Xiao-Long Wei

MicroRNA-133b expression inversely correlates with MET and can serve as an optimum predictive biomarker for patients of colorectal cancer

Biao Xie, Ni Gong, Yihang Guo, Gui Hu

Gene expression profile of THZ1-treated nasopharyngeal carcinoma cell lines indicates its involvement in the inhibition of the cell cycle

Lijuan Gao, Shuang Xia, Kunyi Zhang, Chengguang Lin, Xuyu He, Ying Zhang

Dosimetric evaluation of helical tomotherapy and volumetric-modulated arc therapy for malignant pleural mesothelioma: a planning study for dose escalation

Fu-Li Zhang, Na Lu, Hua-Yong Jiang, Dian-Dian Chen, Ya-Di Wang

Geographic heterogeneity in the outcomes of patients receiving immune checkpoint inhibitors for advanced solid tumors: a meta- analysis

Manyu Li, Jiannan Yao, Huiyun Zhang, Yang Ge, Guangyu An

Development and validation of a prognostic nomogram for predicting the overall survival of myxofibrosarcoma patients: a large population-based study

Shuai Cao, Jie Li, Jun Zhang, Haopeng Li

Extended field or pelvic intensity-modulated radiotherapy with concurrent cisplatin chemotherapy for the treatment of post-surgery multiple pelvic lymph node metastases in cervical cancer patients: a randomized, multi-center phase II clinical trial

Weiming Luo, Yunhai Li, Guihao Ke, Xiaohua Wu, Xiao Huang

miR-30c-5p inhibits glioma proliferation and invasion via targeting Bcl2

Li-Qun Yuan, Tan Zhang, Liang Xu, Hui Han, Shi-Hai Liu

Assessing efficacy and safety of stereotactic body radiation therapy for oligometastatic non-small cell lung cancer with epidermal growth factor receptor (EGFR) wild type

Xiaolong Hu, Hongqi Li, Hefei Liu, Zhifei Liu, Tingyi Xia, Jianchun Zhang, Yingjie Wang

Circulating tumor cells and neutrophil-lymphocyte ratio are predictive markers for metastatic colorectal cancer patients

Heming Li, Qiuge Liu, Shanshan Liang, Ping Yao, Jinyan Lv, Gang Wang, Rongbin Tang, Tong Zhao, Jiaoyang Li, Lu Xu, Lianli Ma, Ruoyu Wang

The value of pulmonary nodule diameter and consolidation/tumor rate in the prediction of lymph node metastasis in early-stage (cT1N0M0) lung adenocarcinoma

Weipeng Shao, Zhaohua Zhang, Zhan Liu, Zhenrong Zhang, Hongliang Sun, Xiaowei Wang, Hongxiang Feng, Chaoyang Liang, Deruo Liu

The risks and trends of cardiac-specific mortality associated with chemotherapy or radiotherapy in a large cohort of non-elderly patients with non-small cell lung cancer

Kai-Ting Jiang, Ding-Zhi Huang

Correlation between the overexpression of epidermal growth factor receptor and pathological features of gastric cancer: a meta-analysis

Fan Cui, Xi Zhang

Prognostic value of combined pretreatment fibrinogen and neutrophil-lymphocyte ratio in digestive system cancers: a meta-analysis of 17 retrospective studies

Rongqiang Liu, Tianxing Dai, Shiyang Zheng, Mingbin Deng, Guozhen Lin, Yuanda Bao, Zhihua Guo, Guoying Wang

Clinicopathological characteristics of peripheral clinical stage IA lung adenocarcinoma with high Ki-67 expression

Zhan Liu, Hongxiang Feng, Shanwu Ma, Weipeng Shao, Jun Zhang, Zhaohua Zhang, Hongliang Sun, Xinlei Gu, Zhenrong Zhang, Deruo Liu

A bibliometric analysis on studies of nanomedicine applications in head and neck squamous cell carcinoma

Xiaolan Gao, Shizhe Wang, Zhuowei Tian, Yunteng Wu, Wei Liu

Involvement of DNA methyltransferase 1 (DNMT1) and multidrug resistance-associated proteins in 2-methoxyestradiol-induced cytotoxicity in EC109/Taxol cells

Qingqing Yang, Xiaojing Guo, Yue Xu, Chang Duan, Haofan Wang, Quanling Feng, Nan Zhang

A bioinformatics analysis to evaluate the prognostic value of stemness-related genes in gastric cancer

Yu-Jie Lu, Lian Lian, Xiao-Ming Shen, Ying Li, Sheng-Jun Ji, Wen-Jie Wang, Yi Yang, Ying Wang, Wei-Ming Duan

The use of trastuzumab affected by health insurance policy in Jiangsu Province of China

Yiqin Xia, Mingjie Zheng, Xiang Zhan, Ying Liu, Susheng Cao, Qing Shao, Dong Meng, Liyan Jin, Lingyun Xu, Tongbo Yi, Hui Xie, Shui Wang

Novel long noncoding RNA (lncRNA) panel as biomarkers for prognosis in lung squamous cell carcinoma via competitive endogenous RNA (ceRNA) network analysis

Tao Zhang, Lei Deng, Ying Ji, Guowei Cheng, Dan Su, Bin Qiu

Gain of GAS5 reveals worse prognosis in kidney renal clear cell carcinoma and liver hepatocellular carcinoma from the Cancer Genome Atlas dataset

Jingjing Li, Yan Li, Xiaoshun He, Qiang Zhao

Identification of six hub genes and analysis of their correlation with drug sensitivity in acute myeloid leukemia through bioinformatics

Daxia Cai, Jiajian Liang, Xing-Dong Cai, Ying Yang, Gexiu Liu, Fenling Zhou, Dongmei He

A novel nomogram to predict the overall survival of patients with colloid adenocarcinoma of the lung

Jun Zhang, Deruo Liu

The knowledge, attitude and practice of hospital pharmacists on the safety issues of antitumor agents for the patients discharged in China

Xiuli Xu, Yuhui Yang, Qianqian Fan, Zhu Zhu

Periostin is a novel histological biomarker for the diagnosis of chondroid tumor

Dough Kim, Ji Yun Jeong, Man-Hoon Han, Jongmin Chae, Ilhyung Park, Jongphil Yoon, Heesoo Kyung, Ha-Jeong Kim, Wonju Jeong

Decrease in radiation therapy rates in patients with stage I seminoma: a population-based study

Shi Jia, Jingping Qiu

Identification of potential biomarkers and available drugs for oral squamous cell carcinoma

Zhijun Zhang, Fei Bi, Zhuang Zhang, Weidong Tian, Weihua Guo

CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines

Jianfeng Shi, Haishan Zhao, Huan Lian, Linnan Ke, Lei Zhao, Chunren Wang, Qianqian Han

Microarray analysis of miRNA based on the regional lymph node metastasis status of esophageal squamous cell carcinoma

Ying Xu, Dianshui Sun, Xiaodong Zhang, Jie Liu, Jihua Wang, Qianqian Cao, Yongjing Wang, Likuan Hu

Comparison of the two routes of video endoscopic inguinal lymphadenectomy in vulvar cancer: a systematic review and a single-center experience

Lixia Luan, Rui Chen, Yang Yang, Fangfang Xue, Wenying Wang

Identification of CDK1 as a candidate marker in cutaneous squamous cell carcinoma by integrated bioinformatics analysis

Si Qin, Yu Yang, Hao-Bin Zhang, Xiao-Huan Zheng, Hua-Run Li, Ju Wen

Clinical characteristics of primary hepatic angiosarcoma outcomes: a SEER database analysis

Dong Zeng, Xianghua Zeng, Jun Duan, Diangang Chen, Bo Zhu

Prognostic value of CEA and CA19-9 in patients with local advanced rectal cancer receiving neoadjuvant chemoradiotherapy, radical surgery and postoperative chemotherapy

Jingjing Shan, Benxing Gu, Liming Shi, Xuanxuan Wang, Wenyuan Ye, Weiwen Zhou, Xiaonan Sun

Predictive value of microvessel features for the clinical response to neoadjuvant chemotherapy in cervical squamous carcinoma and the associations with prognosis

Weili Li, Cong Liang, Ping Liu, Yingying Qi, Hong Shen, Mingwei Li, Chunlin Chen

The construction and validation of the model for predicting the incidence and prognosis of brain metastasis in lung cancer patients

Chunjian Zuo, Guanchu Liu, Ye Bai, Jie Tian, Huanwen Chen

EGFR mutation is positively correlated with C-Met protein expression: a study of 446 resected lung adenocarcinoma

Huizi Lei, Li Liu, Jiacong Wei, Yutao Liu, Yun Ling, Xin Wang, Lei Guo, Weihua Li, Jianming Ying, Lin Yang

Determining the effect of ellagic acid on the proliferation and migration of pancreatic cancer cell lines

Ji Yoon Kim, Yun Ju Choi, Ha-Jeong Kim

The role of Livin expression in the clinicopathological features and prognosis of lung cancer: a meta-analysis

Min Fei, Yingquan Luo, Jian Zhou, Qian Yan

Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma

Ni Li, Jie Liu, Xiaohui Deng

Transcriptome Sequencing reveals the expressed profiles of mRNA and ncRNAs and regulate network via ceRNA mediated molecular mechanism of lung adenocarcinoma bone metastasis in Xuanwei

Lei Han, Zhihong Yao, Lin Xie, Dongqi Li, Cao Wang, Yihao Yang, Jifei Yang, Zeyong Huang, Kecheng Li, Ya Zhang, Lijuan Ye, Zunxian Tan, Yan Liu, Qiuyun Chen, Tiying Wang, Zuozhang Yang

Efficacy of newly discovered DNA aptamers targeting AXL in a lung cancer cell with acquired resistance to Erlotinib

Ji An Hwang, Jae Young Hur, Youndong Kim, Jong Hun Im, Seong Hui Jin, Sung Ho Ryu, Chang-Min Choi

Identification of hub genes in key hallmarks of ovarian cancer via bioinformatics analysis

Rongjia Su, Chengjuan Jin, Chengwen Jin, Menghua Kuang, Jiangdong Xiang

A novel guiding tube modified from a Foley catheter for endostapling during robot-assisted pulmonary resection

Fuqiang Wang, Hanlu Zhang, Yu Zheng, Yun Wang

Highly expressed IFITM10 is associated with early diagnosis and T stage of gastric cancer

Yuanda Liu, Jingjing Liu, Zhenwei Tian, Zhaoyu Zhang, Tong Liu, Chao Chen, Xiaohuan Tang, Jiaming Zhu

KCTD12 is a prognostic marker of breast cancer and correlates with tumor immune cell infiltration

Zhi Wang, Di Wu, Menglu Dong, Yu Xia, Tao Xu

Gene network screening of bladder cancer via modular analysis

Xiaodong Li, Ye Wu, Ye Yuan

Review Article

Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review

Thomas J. Hayman, Aarti K. Bhatia, Krishan R. Jethwa, Melissa R. Young, Henry S. Park

Circulating tumor DNA detection and its application status in gastric cancer: a narrative review

Wenyu Chen, Haijiao Yan, Xiaodong Li, Kele Ge, Jun Wu

The utilization of immunotherapy with radiation therapy in lung cancer: a narrative review

John H. Heinzerling, Kathryn F. Mileham, Charles B. Simone II

MicroRNAs in head and neck squamous cell carcinoma: a possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies

Mahrou Vahabi, Giovanni Blandino, Silvia Di Agostino

Immunotherapy and radiation for high-grade glioma: a narrative review

Kareem R. Fakhoury, Douglas E. Ney, D. Ryan Ormond, Chad G. Rusthoven

Narrative review of immunotherapy and radiation therapy in elderly patients

Brittney Chau, Jonnby LaGuardia, Caressa Hui, Linda Ye, Yan Xing, Erminia Massarelli, Arya Amini

A narrative review of combining radiation and immunotherapy in gastroesophageal cancers

Kevin Yoon, Yi-Jen Chen, Joseph Chao

Vitamin D modulation and microRNAs in gastric cancer: prognostic and therapeutic role

Elena Gallardo Martin, Antia Cousillas Castiñeiras

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Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.

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