Home - Translational Cancer Research

Interviews with Outstanding Authors (2022)

In 2022, many authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspectives and insightful views as authors.

Reviewer of the Month (2022)

In 2022, TCR reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Hereby, we would like to highlight some of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer. Allow us to express our heartfelt gratitude for their tremendous effort and valuable contributions to the scientific process.

New Impact Factor for Translational Cancer Research: 0.496

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2021 citation year: 0.496.

We strive to follow the best practices in publishing. Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their significant contributions.

Translational Cancer Research (TCR) is now a member of Committee on Publication Ethics (COPE)

Starting from July 2021, AME Publishing Company is formally recognized a publisher member of Committee on Publication Ethics (COPE) and over 60 AME-published journals become a member of Committee on Publication Ethics (COPE), as part of AME’s commitment to best practice in scholarly publishing. Translational Cancer Research (TCR) is among the list of COPE membership.

Translational Cancer Research is indexed in PubMed/PMC: A tremendous step forward

We are delighted to announce that Translational Cancer Research (TCR) has passed the Scientific Quality Review by NLM for PMC. TCR is now indexed in PubMed/PMC, two important and extensive biomedical digital databases, which means publications in TCR will enjoy maximum exposure. All articles published in TCR from 2019 onwards will be available in PubMed/PMC within 1-2 months.

Clinic and Therapeutic Potential of Non-coding RNAs in Cancer

The present special series will explore todays knowledge about the potential role of ncRNAs in the clinic, especially in the liquid biopsy field, and intends to shed light into the future questions to be raised on this matter.

Synergy in Action: Novel Approaches to Combining Radiation Therapy and Immunotherapy

We are pleased to have multiple experts of their respective fields review and discuss the current literature and ongoing trials combining RT and immunotherapy. After reading our edition, I hope you have a better overview of where the oncology field is heading and how together with both RT and immunotherapy, we can continue our efforts to treat and potentially cure our patients with cancer.

TCR 2020 Annual Report

Greetings from Editor-in-Chief and Editorial Office of Translational Cancer Research!

We are pleased to share the 2020 Annual Report of Translational Cancer Research here. 2020 has seen much progress for TCR. We hope 2021 will bring greater things to TCR. We would like to thank you for your support and assistance in improving the journal over the past year, and we certainly look forward to your innovations and contributions in 2021.

We would especially like to express our sincere gratitude to the editorial board members, guest editors, reviewers, authors and readers for all your support and contributions to TCR. We wish you a happy, healthy and prosperous 2021!

Endometrial Cancer

The articles published in this special series can be considered a significant step forward in our knowledge about endometrial cancer and stimulate further discussion among the readers. In particular, the novel pieces of information contained in these articles may lead to important changes in the clinical practice and potential paradigm shifts in the future management of endometrial cancer.

Urothelial Carcinoma

The editors wanted to introduce an interesting and varied topic of UC and would like to thank prominent researchers of bladder cancer around the world who participated in this topic.

Loco-regional Therapy for Metastatic Breast Cancer

Patients with MBC can survive longer without metastatic symptoms when treated with these systemic therapies. However, MBC cannot be cured with ICI or other treatments and the majority of MBC patients will die of their disease. It is important to use all available treatments to obtain maximal control of symptoms, prevent serious complications, and prolong life with minimal disruption of daily activities and quality of life. We endeavor to use fewer powerful drugs, such as hormone therapy and oral agents, and thereby minimize severe adverse events.

Energy Balance, Aging, Obesity, and Cancer

This issue of TCR features a series of articles on the impact of obesity, diabetes, and cancer in the older adult population, focuses on providing a better understanding of the processes noted above, how they may influence cancer promotion and progression, and how they may be mitigated to reduce cancer incidence and its comorbidities.

‹ ›

Vol 11, No 9 (September, 2022)

About tcr

Manuscript Submission

AME Editing Service

Reprint & Permission

Advertising

Contact us

General editorial enquiries:
Email: tcr@amepc.org
Copyright related contact:
Email: permissions@amegroups.com
Commercial Sales contact (Reprints, advertising, etc.):
Email: sales@amegroups.com

Announcement more

Testimonials from prestigious Editorial Board Members

Prestigious editorial board members of Translational Cancer Research (TCR) recommend the journal according to their knowledge to TCR and their personal interaction with it. The... More >>

New Impact Factor for Translational Cancer Research: 0.496

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2021 citation year: 0.496. More >>

Translational Cancer Research is indexed in PubMed/PMC: A tremendous step forward

We are delighted to announce that Translational Cancer Research (TCR) has passed the Scientific Quality Review by NLM for PMC. TCR is now indexed in PubMed/PMC, two important... More >>

Editorial

Immune checkpoint inhibitors for non-small cell lung cancer patients on steroid or non-steroidal anti-inflammatory drugs treatment—therapeutic indication or therapeutic efficacy?

Akikazu Kawase

PDF Pages: 3003-3005 Full Text (28) COI Form Open Access

Double trouble: combined large-cell neuroendocrine and small-cell lung carcinoma

David Fisch, Petros Christopoulos

PDF Pages: 3006-3011 Full Text (72) COI Form Open Access

EBV and further emerging directions towards increased precision in gastric cancer treatment

Luana B. C. Santos, Thais F. Bartelli, Diana N. Nunes, Emmanuel Dias-Neto

PDF Pages: 3012-3014 Full Text (55) COI Form Open Access

Survival benefit of No. 10 lymphadenectomy with spleen preservation

Jeong Ho Song, Sang-Yong Son, Hoon Hur, Sang-Uk Han

PDF Pages: 3015-3016 Full Text (29) COI Form Open Access

Original Article

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer

Martin Svaton, Marie Drosslerova, Ondrej Fischer, Miloslav Marel, Michal Hrnciarik, Ondrej Venclicek, Petr Zuna, Michal Svoboda, Jiri Blazek, Monika Bratova, Andrea Mullerova, Bohuslava Vankova, Daniel Krejci

PDF Pages: 3017-3023 Full Text (21) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Efficacy of the No. 10 lymphadenectomy with spleen preservation on patients with gastric cancer and/or esophagogastric junction adenocarcinoma who underwent total gastrectomy: a systematic review and meta-analysis

Bo-Wei Xia, Chen Wang, Yong-Yong Liu, Yong Fan, Xiao-Dong He, Ying-Xin Kang, Xin-Yuan Zhou, Xiao-Lu Su, Yue-Bin Wang, Min-Xue Chen, Bo-Xiong Kang

PDF Pages: 3024-3038 Full Text (26) Reporting Checklist Peer Review File COI Form Open Access

Integrated bioinformatic analysis of potential biomarkers of poor prognosis in triple-negative breast cancer

Rassanee Bissanum, Rawikant Kamolphiwong, Raphatphorn Navakanitworakul, Kanyanatt Kanokwiroon

PDF Pages: 3039-3049 Full Text (23) Reporting Checklist COI Form Open Access

Construction of a competing endogenous RNA network in head and neck squamous cell carcinoma by pan-cancer analysis

Dayuan Zheng, Shiwei Luo, Sen Wang, Jiaqian Huang, Yixing Zhou, Lijun Su, Zhuoting Chen, Shunlan Wang, Weiping He

PDF Pages: 3050-3063 Full Text (29) Reporting Checklist Data Sharing Statement COI Form Open Access

Construction and validation of prognostic prediction established on N6-methyladenosine related genes in cervical squamous cell carcinoma

Danxia Chen, Wenhao Guo, Hailan Yu, Jianhua Yang

PDF Pages: 3064-3079 Full Text (31) Reporting Checklist Peer Review File COI Form Open Access

High expression of hypoxia-inducible factor 1-alpha predicts poor prognosis in pancreatic ductal adenocarcinoma: a meta-analysis and database validation protocol

Alexis Zoa, Yingjie Yang, Wenjin Huang, Jing Yang, Jiangping Wang, Haibo Wang, Minghua Dong, Yuantong Tian

PDF Pages: 3080-3091 Full Text (28) Reporting Checklist Peer Review File COI Form Open Access

Thematic trends and knowledge structure map of sentinel lymph node biopsy for breast cancer: a bibliometric analysis from 2010 to 2019

Yujie Huo, Ting Fan, Si Chen, Qiannan Liu, Yue Fang, Fan Yao

PDF Pages: 3092-3107 Full Text (24) Peer Review File COI Form Open Access

Genomic analysis of the endosomal sorting required for transport complex III pathway genes as therapeutic and prognostic biomarkers for endometrial carcinoma

Ye Yang, Min Wang

PDF Pages: 3108-3127 Full Text (22) Reporting Checklist Peer Review File COI Form Open Access

A nomogram and risk classification model predicts prognosis in Chinese esophageal squamous cell carcinoma patients

Jiaying Deng, Xiaoling Weng, Weiwei Chen, Junhua Zhang, Longfei Ma, Kuaile Zhao

PDF Pages: 3128-3140 Full Text (29) Reporting Checklist Data Sharing Statement COI Form Open Access

Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study

Heming Ge, Zhongyi Zhou, Yuqiang Li, Dan Wang, Cenap Güngör

PDF Pages: 3141-3155 Full Text (30) Reporting Checklist COI Form Open Access

Development and validation of an online prognostic nomogram for osteosarcoma after surgery: a retrospective study based on the SEER database and external validation with single-center data

Liwen Feng, Yuting Chen, Ting Ye, Zengwu Shao, Chengzhi Ye, Jing Chen

PDF Pages: 3156-3174 Full Text (30) Reporting Checklist Data Sharing Statement COI Form Open Access

A newly identified pyroptosis-related gene signature for predicting prognosis of patients with hepatocellular cancer

Qinyan Shen, Yangping Jiang, Xihong Hu, Zhenwu Du

PDF Pages: 3175-3186 Full Text (32) Reporting Checklist COI Form Open Access

A comprehensive pan-cancer analysis on the immunological role and prognostic value of TYMP in human cancers

Yalan Yang, Li Jiang, Sixue Wang, Huan Chen, Mingyu Yi, Yuqing Wu, Zeying Li, Xiaoling Fang

PDF Pages: 3187-3208 Full Text (28) Reporting Checklist Data Sharing Statement COI Form Open Access

High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer

Shengjie Zhang, Yi Wang, Li Yuan, Can Hu, Zhiyuan Xu, Xiangdong Cheng

PDF Pages: 3209-3221 Full Text (19) Reporting Checklist Data Sharing Statement COI Form Open Access

Expression and clinical significance of FGFR1 and FGFR2 in laryngeal squamous cell carcinoma

Mengdie Hu, Shujun Zhang

PDF Pages: 3222-3234 Full Text (27) Reporting Checklist Data Sharing Statement COI Form Open Access

Screening and verification of prognostic lncRNA markers related to immune infiltration in the metastasis of osteosarcoma

Chuan He, Xiaolong Wang, Linying Ni, Chunyu Song, Wei Mai

PDF Pages: 3235-3249 Full Text (81) Reporting Checklist COI Form Open Access

Effects of Shu Bu Wenshen Guchang recipe on intestinal injury and the TLR4/NF-κB signaling pathways in mice with irinotecan-induced delayed-type diarrhea

Qiong Zhang, Feilong Jiang, Jin Tao, Huaibi Wang, Mingling Sun, Yancheng He, Zonglang Lai

PDF Pages: 3250-3259 Full Text (73) Reporting Checklist Data Sharing Statement COI Form Open Access

The short-term outcomes for the early removal of pigtail catheter drainage within 24 hours of uniportal video-assisted anatomic surgery in patients with lung cancer

Shuo Zheng, Qinlang Shi, Qinya Ma, Qiang Fu, Kun Qiao

PDF Pages: 3260-3266 Full Text (24) Reporting Checklist Data Sharing Statement COI Form Open Access

Transrectal endoscopic ultrasound-guided fine-needle aspiration biopsy for qualitative diagnosis of pelvic space-occupying lesions: a diagnostic test

Wei Cai, Guilian Cheng, Fang Tao, Duanmin Hu, Wei Wu

PDF Pages: 3267-3276 Full Text (31) Reporting Checklist Data Sharing Statement COI Form Open Access

ThinPrep cytologic test combined with HPV typing to evaluate the degree of cervical diseases and the relationship between HPV typing and the pathological results of patients with atypical squamous cells of undetermined significance: a diagnostic test

Ling Wang, Qingxia Song, Ying Liu, Qiang Ou

PDF Pages: 3277-3286 Full Text (25) Reporting Checklist Data Sharing Statement COI Form Open Access

Network pharmacology analysis of the mechanism of Huisheng oral liquid in the treatment of lung cancer

Juan Yan, Na Ma, Ke-Qin Liu, Ting-Ting Qiao, Yu Wang, Jin-Xing Xue, Xiu-Qing Hao, Mao-Dong Zheng

PDF Pages: 3287-3297 Full Text (27) COI Form Open Access

Review Article

Is immunotherapy at reduced dose and radiotherapy for older patients with locally advanced non-small lung cancer feasible?—a narrative review by the international geriatric radiotherapy group

Vincent Vinh-Hung, Olena Gorobets, Andre Duerinkcx, Suresh Dutta, Eromosele Oboite, Joan Oboite, Ahmed Ali, Thandeka Mazibuko, Ulf Karlsson, Alexander Chi, David Lehrman, Omer Hashim Mohammed, Mohammad Mohammadianpanah, Gokoulakrichenane Loganadane, Natalia Migliore, Maria Vasileiou, Nam P. Nguyen, Huan Giap

PDF Pages: 3298-3308 Full Text (37) Reporting Checklist Peer Review File COI Form Open Access

Case Report

Infliximab in the treatment of tislelizumab-induced steroid-refractory immune checkpoint inhibitor-related pneumonia: case report and literature review

Zhujun Chen, Jian He

PDF Pages: 3309-3314 Full Text (26) Reporting Checklist Peer Review File COI Form Open Access

Misdiagnosis of primary mucosa-associated lymphoid tissue lymphoma of the pleura: case report and literature review

Yao-Hui Wang, Ling Peng, Jie-Han Jiang, Yun Xiao, Zhi-Ruo Zhu, De Tong, Zhi-Hui Shi, Wen-Long He, Qing-Wu Qin, Ding Liang, Yi Jiang, Hong Luo, Rui Zhou, Kui Xiao

PDF Pages: 3315-3321 Full Text (18) Reporting Checklist COI Form Open Access

Determination of the best surgical strategy for thoracic esophageal resection concurrent with double aortic arch using a three-dimensional model: a case report

Kenji Hamada, Yusuke Taniyama, Yoshiyuki Yashima, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Michiaki Unno, Takashi Kamei

PDF Pages: 3322-3328 Full Text (19) Reporting Checklist Peer Review File COI Form Open Access

Successful outcome of neoadjuvant PD-1 blockade, VEGFR-2 inhibitor plus chemotherapy for potentially unresectable esophagogastric junctional squamous cell carcinoma: a case report

Kai-Bo Chen, Zhi-Wei Wu, Yi Huang, Mu-Xing Kang, Le-Le Lin, Shan-Shan Jiang, Hui Zhang, Ya-Jing Huang, Li Chen

PDF Pages: 3329-3336 Full Text (26) Reporting Checklist COI Form Open Access

Intracranial complete response to toripalimab and anlotinib in a patient with recurrent brain metastases of small cell lung cancer after failure of second-line maintenance therapy: a case report

Fengxiang Huang, Jiaqi Tang, Jiaojiao Lou, Qilong Wang, Kai Ma, Ruiping Qiao, Jiming Si, Yan Kang, Hongjie Chen, Jingjing Mei, Huanqin Wang, Yuanhua Liu, Lijun Miao

PDF Pages: 3337-3342 Full Text (22) Reporting Checklist COI Form Open Access

Advanced lung adenocarcinoma (LUAD) patient with EGFR mutations benefited from multiline combination targeted therapies after osimertinib (AZD9291) resistance: a case report

Jingyu Chen, Xueqi Zhao, Jinlin Wang, Fangfang Liu, Linli Zhang, Yuan Chen, Qian Chu

PDF Pages: 3343-3348 Full Text (20) Reporting Checklist Peer Review File COI Form Open Access

Leptomeningeal metastasis from de novo metastatic nasopharyngeal carcinoma: a case report

Xin Zhang, Xiaolei Shu, Bin Long

PDF Pages: 3349-3356 Full Text (30) Reporting Checklist COI Form Open Access

Advanced non-small cell lung cancer treated with palliative systemic therapy complicated by calvarial metastasis: a case report

Sapan Patel, Brittany Zaita, Adityabikram Singh, Vivas Tatachar, Sunaina Dias, Emma Fattakhov, Gurjinder Kaur

PDF Pages: 3357-3362 Full Text (20) Reporting Checklist Peer Review File COI Form Open Access

Primary mesenchymal chondrosarcoma of the adult lumbar spine: a case report and review of the literature

Maoqiang Lin, Haiyu Zhou, Xiaobo Zhang, Yicun Hu, Taowen Guo, Jintao Shi

PDF Pages: 3363-3370 Full Text (39) Reporting Checklist Peer Review File COI Form Open Access

Rare malignant primary spinal intradural extramedullary mesenchymal chondrosarcoma: a case report and literature review

Yunda Wang, Xin Meng, Wenqing Liu, Haocong Wang, Tao Xin

PDF Pages: 3371-3378 Full Text (19) Reporting Checklist COI Form Open Access

A recurrent inflammatory myofibroblastic tumor patient with two novel ALK fusions: a case report

Xiumei Xu, Ling Li, Yaxuan Zhang, Fanfan Meng, Hongmei Xie, Ruiqi Duan

PDF Pages: 3379-3384 Full Text (20) Reporting Checklist COI Form Open Access

Perioperative management of intrahepatic cholangiocarcinoma patients with hereditary coagulation factor V deficiency: a case report and literature review

Jianlin Lai, Junyi Wu, Yangyang Huang, Hui Cheng, Yannan Bai, Funan Qiu

PDF Pages: 3385-3390 Full Text (21) Reporting Checklist Peer Review File COI Form Open Access

Ovarian metastases from ALK-positive lung adenocarcinoma: a case report and review of the literature

Huixin Li, Yan Chen, Yingchun Wang, Lin Zhou, Zhongfu Tian, Mengyu Liu, Yang Li, Hanzi Xu, Wangfei Wu, Zhen Gong

PDF Pages: 3391-3399 Full Text (26) Reporting Checklist COI Form Open Access

Radiation induced lung injury (RILI) after postoperative intensity modulated proton therapy (IMPT) in a patient with stage III locally advanced lung adenocarcinoma: a case report

Zixin Hu, Jiabin Zheng, Ying Xiong, Kexin Tan, Xu Zhang, Yixuan Yu, Huijing Dong, Xingyu Lu, Guangying Zhu, Huijuan Cui

PDF Pages: 3400-3408 Full Text (25) Reporting Checklist COI Form Open Access

CT and MRI findings of intracranial extraskeletal mesenchymal chondrosarcoma—a case report and literature review

Jixiang Chu, Huan Ma, Yao Wang, Kun Li, Chengde Liao, Yingying Ding

PDF Pages: 3409-3415 Full Text (19) Reporting Checklist Peer Review File COI Form Open Access

Pembrolizumab for treatment of a male with primary mediastinal choriocarcinoma: a case report

Weiyu Pan, Jun Hou

PDF Pages: 3416-3420 Full Text (29) Reporting Checklist COI Form Open Access

Endometrial stromal sarcoma metastatic to the inferior vena cava: a case report and literature review

Ying Zhang, Zhiyong Wei, Jia Yan, Keliang Xie, Zhiqiang Wang

PDF Pages: 3421-3425 Full Text (22) Reporting Checklist COI Form Open Access

Intradural spinal seeding metastasis of clival chordoma: a case report

Xiaohai Liu, Mingchu Li, Ge Chen

PDF Pages: 3426-3433 Full Text (20) Reporting Checklist Peer Review File COI Form Open Access

Primary hepatic paraganglioma mimicking hepatocellular carcinoma: a case report

Li Li, Pei-Pei Fei, Zhi-Yun Guo, Juan Wang, Ze-Ya Pan, Cheng-Gang Xu, Jian Huang

PDF Pages: 3434-3439 Full Text (22) Reporting Checklist COI Form Open Access

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review

Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors

Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen

Common applications of next-generation sequencing technologies in genomic research

Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Magnetic resonance imaging of pancreatic malignancy

Mellena D. Bridges

EGFR and HER2: is there a role in ovarian cancer?

Eleonora Teplinsky, Franco Muggia

Advances on immunotherapy in breast cancer

Kanthi Athreya, Sonia Ali

Targeting the folate receptor for the treatment of ovarian cancer

Robert J. Lutz

Computational resources for radiomics

Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang

Editorial

Morphine, when used for treating patients with acute pancreatitis, could be more risky than previously suspected

Juan Iovanna, Maria Cecilia Mallmann

The CROSS road in neoadjuvant therapy for esophageal cancer: long-term results of CROSS trial

Ian Wong, Simon Law

Immunotherapy in endometrial cancer: who are the most appropriate patients?

Katherine C. Kurnit, Amir A. Jazaeri

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis

Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Mini-Review

The emerging role of chemokine receptor CXCR2 in cancer progression

Tanweer Jaffer, Daqing Ma

Original Article

Impact of image preprocessing on the volume dependence and prognostic potential of radiomics features in non-small cell lung cancer

Xenia Fave, Lifei Zhang, Jinzhong Yang, Dennis Mackin, Peter Balter, Daniel Gomez, David Followill, A. Kyle Jones, Francesco Stingo, Laurence Court

Review Article

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

Liquid biopsy for cancer screening, patient stratification and monitoring

Graham Brock, Elena Castellanos-Rizaldos, Lan Hu, Christine Coticchia, Johan Skog

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Review Articles

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer

Deep Kwatra, Anand Venugopal, Shrikant Anant

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer

Rositsa Dueva, George Iliakis

Radiosensitization by gold nanoparticles: effective at megavoltage energies and potential role of oxidative stress

Karl T. Butterworth, Stephen J. McMahon, Laura E. Taggart, Kevin M. Prise

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Biological basis of IORT

Immune effects of high dose radiation treatment: implications of ionizing radiation on the development of bystander and abscopal effects

Ithaisa Sologuren, Carlos Rodríguez-Gallego, Pedro Carlos Lara

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data

Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Statistical strategies for microRNAseq batch effect reduction

Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr

Defining functional changes in the brain caused by targeted stereotaxic radiosurgery

Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli

A chain reaction approach to modelling gene pathways

Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes

Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA

Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li

Identification of cancer mechanisms through computational systems modeling

Zhen Qi, Eberhard O. Voit

Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases

Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy

Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines

Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer

Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park

How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis

Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao

Alcohol intake patterns for cancer and non-cancer individuals: a population study

Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng

Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial

Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data

Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley

Sparse principal component analysis in cancer research

Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen

An improved understanding of cancer genomics through massively parallel sequencing

Jamie K. Teer

Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications

Louis Dubeau

Cancer biomarker discovery and validation

Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida

The promise and challenge of ovarian cancer models

Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management

Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas

Exosomal lncRNAs as new players in cell-to-cell communication

Mihnea Dragomir, Baoqing Chen, George A. Calin

Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy

Souparno Bhattacharya, Aroumougame Asaithamby

Translational research in radiation-induced DNA damage signaling and repair

Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue

Genetically engineered mouse models for studying radiation biology

Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch

Renal cell carcinoma: the search for a reliable biomarker

Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer

Advances on immunotherapy in genitourinary and renal cell carcinoma

Gregory P. Botta, Eric Granowicz, Carrie Costantini

The role of novel immunotherapies in non-Hodgkin lymphoma

Allyson Pishko, Sunita D. Nasta

MDMX under stress: the MDMX-MDM2 complex as stress signals hub

Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan

Do p53 stress responses impact organismal aging?

Paul Hasty, Judith Campisi, Z. Dave Sharp

Pharmacological targeting of mutant p53

Samuel Kogan, Darren Carpizo

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis

Michael I. Carr, Stephen N. Jones

Regulation of cytotoxic T-cell responses by p53 in cancer

Mitchell W. Braun, Tomoo Iwakuma

The IGF-1R/AKT pathway determines cell fate in response to p53

Lei Duan, Carl G. Maki

Intra molecular interactions in the regulation of p53 pathway

Jiandong Chen

TP53 mutations in epithelial ovarian cancer

Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu

Modulation of the p53 family network by RNA-binding proteins

Chris Lucchesi, Jin Zhang, Xinbin Chen

Radiomics in head and neck cancer: from exploration to application

Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller

Prostate cancer radiomics and the promise of radiogenomics

Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack

Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies

Wei Lu, Wengen Chen

The emerging field of radiomics in esophageal cancer: current evidence and future potential

Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin

Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire

Jung H. Suh, Julie D. Saba

Computational methods and opportunities for phosphorylation network medicine

Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury

M. Kerry O’Banion

Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic

Naomi Lomeli, Daniela A. Bota

Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma

David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright

New light on the pancreatic cyst conundrum

Nathan A. Berger

HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?

Andrew J. Scott, John C. Wilkinson

Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts

Kristopher A. Lyon, Jason H. Huang

Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4

Nan Ding, Qianzheng Zhu

Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?

Apar Gupta, Nisha Ohri, Bruce G. Haffty

Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents

Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi

CRISPR-based genetic interaction maps inform therapeutic strategies in cancer

Poornima Ramkumar, Martin Kampmann

Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study

Melin J. Khandekar, Rakesh Jain

The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin

Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed

Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer

Joanne P. Young, Timothy J. Price, Susan Parry

Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response

R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang

Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes

Theresa L. Whiteside

TIC10/ONC201—a potential therapeutic in glioblastoma

Georg Karpel-Massler, Markus D. Siegelin

IDH mutational status and the immune system in gliomas: a tale of two tumors?

Bryan D. Choi, William T. Curry

ONC201: a new treatment option being tested clinically for recurrent glioblastoma

Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry

When better still might not be good enough

Waldemar Debinski

Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy

Vincent C. O. Njar

Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28

Leonardo Chicaybam, Prasad S. Adusumilli

Exosome mediated phenotypic changes in lung cancer pathophysiology

Yoshihisa Shimada, John D. Minna

Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma

Aaron D. DeWard, Rebecca J. Critchley-Thorne

From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein

Felicia L. Lenzo, William G. Cance

New incriminating evidence against IGF2

Wen Ding, Lina A. Shehadeh

Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect

Paul Grippo, Ajay V. Maker

Branched chain amino acid metabolism and cancer: the importance of keeping things in context

Elizabeth M. Selwan, Aimee L. Edinger

RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver

Satomi Yamamoto, Tomoo Iwakuma

Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy

Michael J. Baine, Chi Lin

Rogue one: another faction of the Wnt empire implicated in assisting GBM progression

Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed

Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway

Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano

Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems

Li Tian, Ashley Chang, Marites P. Melancon

IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm

James P. White

Low-frequency ultrasound may improve drug penetration in colonic mucosa

Qiubing Chen, Bo Xiao, Didier Merlin

Dividing and conquering the variation among variants in EML4-ALK lung cancer

Trever G. Bivona

Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu, Huidong Shi

KDM1 links nuclear GSK3β to epigenetic alterations

Weijie Guo, Binhua P. Zhou

Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease

Deepa Rangachari, Daniel B. Costa

Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy

Bhagelu R. Achyut, Ali S. Arbab

Neuroendocrine differentiation in prostate cancer: key epigenetic players

Karishma Gupta, Sanjay Gupta

PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression

Kim A. Brogden, Shireen Vali, Taher Abbasi

Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy

Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies

Keith T. Schmidt, William D. Figg

Information-dense analysis for information-dense understanding

Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen

The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use

Angel Qin, Nithya Ramnath

Immune infiltration, glioma stratification, and therapeutic implications

Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher

Balancing redox stress: anchorage-independent growth requires reductive carboxylation

Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione

Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy

Fabiana Perna, Michel Sadelain

Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells

Alex J. Gooding, William P. Schiemann

Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?

Nathan A. Berger

Microtubule targeting agents in glioma

Anda-Alexandra Calinescu, Maria G. Castro

Moving molecular subtypes to the clinic in gastric cancer

Joseph Chao, Jeeyun Lee, Samuel J. Klempner

Intraoperative subtyping of lung adenocarcinoma: an unmet need

Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli

Emerging roles of FGF signaling in hepatocellular carcinoma

Nana Zheng, Wenyi Wei, Zhiwei Wang

Tregs, Helios and tumor immunity: the sun has not yet risen

Angela M. Thornton, Ethan M. Shevach

Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1

Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof

Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components

Brandon J. Manley, James J. Hsieh

Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer

Salma Kaochar, Nicholas Mitsiades

Letter to the Editor

Epigenetic regulation of PD-L1 expression and pancreatic cancer response to checkpoint immunotherapy

Chunwan Lu, Kebin Liu

Synthetic lethality vs. synthetic viability due to PARP1 and BRCA2 loss

Xia Ding, Shyam K. Sharan

Correspondence

Targeted attack: mechanisms by which ovarian cancers suppress the immune system

Irina V. Tiper, Tonya J. Webb

Brief Report

The impact of neighborhood disadvantage on health-related quality of life among African American and white cancer survivors

Chien-Ching Li, Alicia K. Matthews, Anjali Asthana, Raj C. Shah

Research Highlight

Butyrate consumption of differentiated colonocytes in the upper crypt promotes homeostatic proliferation of stem and progenitor cells near the crypt base

Scott J. Bultman

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike

Jeffrey J. Tosoian, Emmanuel S. Antonarakis

A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer

Sawsan Rashdan, David E. Gerber

MOAP-1, UBR5 and cisplatin resistance in ovarian cancer

Scott T. Eblen, Amber Bradley

Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer

Weimin Gao

The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)

Theresa L. Whiteside

[¹⁸F]-choline PET/CT as an imaging biomarker for primary liver cancers

Zhenghong Lee

Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best

Yoshio Yamaoka, David Y. Graham

JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function

Theodoros Karantanos, Vassiliki A. Boussiotis

Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer

Angel Qin, Gregory P. Kalemkerian

Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered

Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

Praveen Kumar Vemula, Venkatakrishna Rao Jala

Helios—controller of Treg stability and function

Claire Chougnet, David Hildeman

Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation

Jon K. Obst, Marianne D. Sadar

Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase

Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird

Fat lure: adipocytes attract cancer cells out of the prostate

Alexandra M. Blee, Haojie Huang

Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers

Guoli Chen, Ming-Tseh Lin

Editorials

Into the eye of the storm: breast cancer’s somatic mutation landscape points to DNA damage and repair

Joanne Ngeow, Emily Nizialek, Charis Eng

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks

Apratim Mitra, Karl Pfeifer, Ki-Sun Park

The STAMPEDE trial: paradigm-changing data through innovative trial design

Bradley C. Carthon, Emmanuel S. Antonarakis

Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway

Derek B. Oien, Jeremy Chien, Nikki Cheng

Feed your gut with caution!

Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar

Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma

Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma

Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients

Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy

Reinhard W. Schulte, Andrew J. Wroe

Externally modulated theranostic nanoparticles

Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi

Intestinal stem cell injury and protection during cancer therapy

Jian Yu

Cancer stem cells in glioma: challenges and opportunities

Jialiang Wang, Yufang Ma, Michael K. Cooper

Tumor microenvironment and nanotherapeutics

Meenakshi Upreti, Amar Jyoti, Pallavi Sethi

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury

Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

Chang-Lung Lee, Jordan M. Blum, David G. Kirsch

DNA ligases as therapeutic targets

Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest

DNA damage tolerance: a double-edged sword guarding the genome

Gargi Ghosal, Junjie Chen

DNA double strand break repair via non-homologous end-joining

Anthony J. Davis, David J. Chen

DNA crosslinking damage and cancer - a tale of friend and foe

Yaling Huang, Lei Li

Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation

Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan

MDM2 and MDMX: alone and together in regulation of p53

Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase

Lijian Shao, Lixian Wu, Daohong Zhou

Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment

Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen

SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis

Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos

Normal tissue protection for improving radiotherapy: where are the Gaps?

Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization

Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn

Molecular mechanisms involved in tumor repopulation after radiotherapy

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules

Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy

Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar

Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma

Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report

Efficacy of osimertinib in a metastatic lung adenocarcinoma patient harboring somatic EGFR delL747_S752 and germline BIM deletion polymorphism: a case report and literature review

Wenyu Zheng, Niu Niu, Jialong Zeng, Xianni Ke, Shi Jin

A case report of pulmonary combined small cell carcinoma with enteric adenocarcinoma

Shouguang Wang, Ye Tan, Ling Li, Yaxuan Zhang, Chuang Liu, Pengyao Du, Fanfan Meng, Bo Li

Neoadjuvant chemotherapy followed by radical vulvectomy for adenoid cystic carcinoma of Bartholin’s gland: a case report

Yuewen Gao, Hongqi Li, Changzhong Li

Anlotinib combined with temozolomide for the treatment of patients with diffuse midline glioma: a case report and literature review

Yiping Feng, Qingsheng Xu, Minwei Fang, Chi Hu

Abscopal effect in a patient with solitary extramedullary plasmacytoma of the thyroid: case report

Mariko Aoyama, Takashi Shono, Tomohiro Inui, Naoki Miyamoto, Shinichi Sakamoto, Seiya Inoue, Satoshi Fujiwara, Masakazu Goto, Hiroaki Toba, Hiromitsu Takizawa

Acute respiratory distress syndrome secondary to carbon dioxide gas embolism after single-port robotic-assisted perineal radical prostatectomy: a case report

Shibin Zhu, Chenhao Yu, Hui Wang, Gonghui Li

Transarterial embolization for rare spontaneous subacute intratumoral hemorrhage of hepatic hemangioma: a case report and literature review

Kefeng Jia, Weili Yin, Fang Wang, Zhongsong Gao, Yujuan Han, Mingge Li, Changlu Yu

A patient with stage IIIB advanced breast cancer who is still alive 24 years after surgery: a case report and remarks on the treatment strategies

Toshihiko Yoneto, Kenichiro Hasumi, Yuzo Fujii, Nobukazu Takahashi, Natsuki Seki, Takayuki Yoshimoto, Yasutaka Takeda

Editorial

Diagnostic challenges and considerations of low-grade endometrial stromal sarcoma (LGESS) outside the female genital tract

Shuang Niu

Original Article

Comparison of mediastinal and non-mediastinal neuroblastoma and ganglioneuroblastoma associated with opsoclonus-myoclonus syndrome: a systematic review and meta-analysis

Siqi Xie, Chenghao Bai, Kai Li, Kuiran Dong, Wei Yao

Sociodemographic and clinical characteristics associated with never-smoking status in patients with lung cancer: findings from a large integrated health system

Kian C. Banks, Eric T. Sumner, Amy Alabaster, Diana S. Hsu, Charles P. Jr Quesenberry, Lori C. Sakoda, Jeffrey B. Velotta

MAN2A1 predicts prognosis and progression through cancer-related pathways in colorectal cancer

Yangzi Wang, Jianmin Zhao, Guoxiang Fu, Caixia Sheng, Jia Zhu, Tingting Zhong, Fang Yang, Zhinong Jiang

Clinical features and prognostic factors of esophageal signet ring cell carcinoma: construction and validation of a model based on the SEER database

Rongrong Xie, Guangrong Lu, Lili Li

Surgical treatment of intermediate to high grade thymic neuroendocrine neoplasms: case series of five patients and literature review

Chuan Huang, Yao-Guang Sun, Qing-Jun Wu, Chao Ma, Peng Jiao, Yong-Zhong Wang, Wen Huang, Wen-Xin Tian, Han-Bo Yu, Dong-Hang Li, Hong-Feng Tong

Characteristics of toxicity occurrence patterns in concurrent chemoradiotherapy after induction chemotherapy for patients with locally advanced non-small-cell lung cancer: a pooled analysis based on individual patient data of CALGB/Alliance trials

Lexie Zidanyue Yang, Qihua He, Jianrong Zhang, Apar Kishor Ganti, Thomas E. Stinchcombe, Herbert Pang, Xiaofei Wang

Fluorescence in situ hybridization (FISH) to predict the efficacy of BCG perfusion in bladder cancer

Chunjin Ke, Zhenghao Liu, Junyu Zhu, Xing Zeng, Zhiquan Hu, Chunguang Yang

Novel insight on predicting prognosis of gastric cancer based on inflammation

Zhizhan Ni, Jiuqiang Zhang, Chenshen Huang, Huahao Xie, Bujun Ge, Qi Huang

Development and validation of a combined ferroptosis and immune prognostic signature for lung adenocarcinoma

Han Li, You Ge, Gaoqiang Fei, Zemin Wang, Shuai Wang, Pingmin Wei

Identification of candidate hub genes correlated with the pathogenesis, diagnosis, and prognosis of prostate cancer by integrated bioinformatics analysis

Tianyi Wei, Yulai Liang, Claire Anderson, Ming Zhang, Naishuo Zhu, Jun Xie

The diagnostic performance of contrast-enhanced ultrasound versus contrast-enhanced computed tomography for pancreatic carcinoma: a systematic review and meta-analysis

Xiaoyi Yan, Ke Lv, Mengsu Xiao, Li Tan, Yang Gui, Jing Zhang, Xueqi Chen, Wanying Jia, Jinglin Li

Molecular signature of gastric cancer progression in clinical using whole genome sequencing and the Cancer Genome Atlas (TCGA) analysis

Gai-Gai Wei, Xiao-Chuan Geng, Ming-Sheng Fu, Jun Wei, Hai-Bo Yu, Xiao-Hui Li, Gang-Long Gao

Development and validation of a novel ubiquitination-related gene prognostic signature based on tumor microenvironment for colon cancer

Baoyi Huang, Weiping Deng, Pengfei Chen, Qiuxian Mao, Hao Chen, Zewei Zhuo, Zena Huang, Kequan Chen, Jiayu Huang, Yujun Luo

Bidirectional regulation between tumor cell-intrinsic PD-L1 and TGF-β1 in epithelial-to-mesenchymal transition in melanoma

Zhen Li, Fengdi Wang, Jianzhong Dang, Fanjun Cheng, Fang Zheng

The prognostic role of fatty acid metabolism-related genes in patients with gastric cancer

Wei Xu, He Ding, Man Zhang, Lu Liu, Minyue Yin, Zhen Weng, Chunfang Xu

Mass size is a major predictor of hypertensive attack during surgery in patients with paraganglioma of retroperitoneum

Ji Hyung Yoon, Chang Ryul Park, Myeong Chan Park, Chongsok Chae, Kyung Hyun Moon, Taekmin Kwon, Sang Hyeon Cheon, Seong Cheol Kim, Young Min Kim, So Yun Choi, Ki Soo Lee, Tae Hyo Kim, Sungchan Park

High expression of CD73 contributes to poor prognosis of clear-cell renal cell carcinoma by promoting cell proliferation and migration

Yihong Zhou, Dong Jiang, Xi Chu, Minbo Yan, Hao Qi, Xiang Wu, Yuxin Tang, Yingbo Dai

Treatment decisions of bladder cancer in patients older than 85 years: a SEER-based analysis 2011–2015

Jun Zhu, Xin Ye, Liqun Zhou, Zhisong He, Jie Jin, Wei Yu

Is it justified to assess the resectability of pancreatic cancer combined with biological and conditional factors?

Bingying Huang, Hao Geng, Yun Jin, Xiaoxiao Zhang, Hai Qian, Dan Ye, Jinhong Wu, Huanbing Zhu, Yuanquan Yu, Donger Zhou, Jiangtao Li

The feasibility of MRI texture analysis in distinguishing glioblastoma, anaplastic astrocytoma and anaplastic oligodendroglioma

Yuen Teng, Chaoyue Chen, Yang Zhang, Jianguo Xu

A simple-to-use nomogram for predicting the risk of radiation pneumonitis in patients with thoracic segment esophageal squamous cell carcinoma

Ting Qiu, Yuxia Deng, Haochun Guo, Haijun Zhang

The prognostic value and mechanisms of centromere protein M in patients with lung adenocarcinoma

Ning Qi, Yuxu Niu, Zheng Li, Li Xiao, Dongfang Tang, Wen Gao

FAM83D promotes the proliferation and migration of hepatocellular carcinoma cells by inhibiting the FBXW7/MCL1 pathway

Jiao Nie, Lin Lu, Chao Du, Xiaozhong Gao

Prognostic impact of mitofusin 2 expression in colon cancer

Xiaofei Cheng, Yanqing Li, Fanlong Liu

Identification of prognostic miRNA-mRNA regulatory network in the progression of HCV-associated cirrhosis to hepatocellular carcinoma

Liping Han, Xuemei Jia, Weinire Abuduwaili, Dongping Li, He Chen, Qiuyu Jiang, She Chen, Si Zhang, Rong Xia, Ruyi Xue

Review Article

Utilization of model-agnostic explainable artificial intelligence frameworks in oncology: a narrative review

Colton Ladbury, Reza Zarinshenas, Hemal Semwal, Andrew Tam, Nagarajan Vaidehi, Andrei S. Rodin, An Liu, Scott Glaser, Ravi Salgia, Arya Amini

Journal highlight more

Translational Cancer Research is an international, open access, peer-reviewed journal indexed in Scopus and Science Citation Index Expanded (SCIE), focusing on original, science-based researches on clinical, basic and translational aspects. It publishes laboratory studies of novel therapeutic interventions, clinical trials which evaluate new treatment paradigms for cancer, results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of cancer patients and etc.