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Prestigious editorial board members of Translational Cancer Research (TCR) recommend the journal according to their knowledge to TCR and their personal interaction with it. The... More >>

New Impact Factor for Translational Cancer Research: 0.496

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2021 citation year: 0.496. More >>

Translational Cancer Research is indexed in PubMed/PMC: A tremendous step forward

We are delighted to announce that Translational Cancer Research (TCR) has passed the Scientific Quality Review by NLM for PMC. TCR is now indexed in PubMed/PMC, two important... More >>

Original Article

Comedication with corticosteroids and nonsteroidal antiphlogistics does not affect PD-L1 expression in non-small cell lung cancer
Martin Svaton, Marie Drosslerova, Ondrej Fischer, Miloslav Marel, Michal Hrnciarik, Ondrej Venclicek, Petr Zuna, Michal Svoboda, Jiri Blazek, Monika Bratova, Andrea Mullerova, Bohuslava Vankova, Daniel Krejci
Efficacy of the No. 10 lymphadenectomy with spleen preservation on patients with gastric cancer and/or esophagogastric junction adenocarcinoma who underwent total gastrectomy: a systematic review and meta-analysis
Bo-Wei Xia, Chen Wang, Yong-Yong Liu, Yong Fan, Xiao-Dong He, Ying-Xin Kang, Xin-Yuan Zhou, Xiao-Lu Su, Yue-Bin Wang, Min-Xue Chen, Bo-Xiong Kang
Integrated bioinformatic analysis of potential biomarkers of poor prognosis in triple-negative breast cancer
Rassanee Bissanum, Rawikant Kamolphiwong, Raphatphorn Navakanitworakul, Kanyanatt Kanokwiroon
Construction of a competing endogenous RNA network in head and neck squamous cell carcinoma by pan-cancer analysis
Dayuan Zheng, Shiwei Luo, Sen Wang, Jiaqian Huang, Yixing Zhou, Lijun Su, Zhuoting Chen, Shunlan Wang, Weiping He
Construction and validation of prognostic prediction established on N6-methyladenosine related genes in cervical squamous cell carcinoma
Danxia Chen, Wenhao Guo, Hailan Yu, Jianhua Yang
High expression of hypoxia-inducible factor 1-alpha predicts poor prognosis in pancreatic ductal adenocarcinoma: a meta-analysis and database validation protocol
Alexis Zoa, Yingjie Yang, Wenjin Huang, Jing Yang, Jiangping Wang, Haibo Wang, Minghua Dong, Yuantong Tian
Thematic trends and knowledge structure map of sentinel lymph node biopsy for breast cancer: a bibliometric analysis from 2010 to 2019
Yujie Huo, Ting Fan, Si Chen, Qiannan Liu, Yue Fang, Fan Yao
Genomic analysis of the endosomal sorting required for transport complex III pathway genes as therapeutic and prognostic biomarkers for endometrial carcinoma
Ye Yang, Min Wang
A nomogram and risk classification model predicts prognosis in Chinese esophageal squamous cell carcinoma patients
Jiaying Deng, Xiaoling Weng, Weiwei Chen, Junhua Zhang, Longfei Ma, Kuaile Zhao
Prognostic factors and individualized nomograms predicting overall survival in stage IV rectal cancer patients with different metastatic status: a SEER-based study
Heming Ge, Zhongyi Zhou, Yuqiang Li, Dan Wang, Cenap Güngör
Development and validation of an online prognostic nomogram for osteosarcoma after surgery: a retrospective study based on the SEER database and external validation with single-center data
Liwen Feng, Yuting Chen, Ting Ye, Zengwu Shao, Chengzhi Ye, Jing Chen
A newly identified pyroptosis-related gene signature for predicting prognosis of patients with hepatocellular cancer
Qinyan Shen, Yangping Jiang, Xihong Hu, Zhenwu Du
A comprehensive pan-cancer analysis on the immunological role and prognostic value of TYMP in human cancers
Yalan Yang, Li Jiang, Sixue Wang, Huan Chen, Mingyu Yi, Yuqing Wu, Zeying Li, Xiaoling Fang
High expression of ceramide synthase 5 predicts a poor prognosis in gastric cancer
Shengjie Zhang, Yi Wang, Li Yuan, Can Hu, Zhiyuan Xu, Xiangdong Cheng
Expression and clinical significance of FGFR1 and FGFR2 in laryngeal squamous cell carcinoma
Mengdie Hu, Shujun Zhang
Screening and verification of prognostic lncRNA markers related to immune infiltration in the metastasis of osteosarcoma
Chuan He, Xiaolong Wang, Linying Ni, Chunyu Song, Wei Mai
Effects of Shu Bu Wenshen Guchang recipe on intestinal injury and the TLR4/NF-κB signaling pathways in mice with irinotecan-induced delayed-type diarrhea
Qiong Zhang, Feilong Jiang, Jin Tao, Huaibi Wang, Mingling Sun, Yancheng He, Zonglang Lai
The short-term outcomes for the early removal of pigtail catheter drainage within 24 hours of uniportal video-assisted anatomic surgery in patients with lung cancer
Shuo Zheng, Qinlang Shi, Qinya Ma, Qiang Fu, Kun Qiao
Transrectal endoscopic ultrasound-guided fine-needle aspiration biopsy for qualitative diagnosis of pelvic space-occupying lesions: a diagnostic test
Wei Cai, Guilian Cheng, Fang Tao, Duanmin Hu, Wei Wu
ThinPrep cytologic test combined with HPV typing to evaluate the degree of cervical diseases and the relationship between HPV typing and the pathological results of patients with atypical squamous cells of undetermined significance: a diagnostic test
Ling Wang, Qingxia Song, Ying Liu, Qiang Ou
Network pharmacology analysis of the mechanism of Huisheng oral liquid in the treatment of lung cancer
Juan Yan, Na Ma, Ke-Qin Liu, Ting-Ting Qiao, Yu Wang, Jin-Xing Xue, Xiu-Qing Hao, Mao-Dong Zheng

Review Article

Is immunotherapy at reduced dose and radiotherapy for older patients with locally advanced non-small lung cancer feasible?—a narrative review by the international geriatric radiotherapy group
Vincent Vinh-Hung, Olena Gorobets, Andre Duerinkcx, Suresh Dutta, Eromosele Oboite, Joan Oboite, Ahmed Ali, Thandeka Mazibuko, Ulf Karlsson, Alexander Chi, David Lehrman, Omer Hashim Mohammed, Mohammad Mohammadianpanah, Gokoulakrichenane Loganadane, Natalia Migliore, Maria Vasileiou, Nam P. Nguyen, Huan Giap

Case Report

Infliximab in the treatment of tislelizumab-induced steroid-refractory immune checkpoint inhibitor-related pneumonia: case report and literature review
Zhujun Chen, Jian He
Misdiagnosis of primary mucosa-associated lymphoid tissue lymphoma of the pleura: case report and literature review
Yao-Hui Wang, Ling Peng, Jie-Han Jiang, Yun Xiao, Zhi-Ruo Zhu, De Tong, Zhi-Hui Shi, Wen-Long He, Qing-Wu Qin, Ding Liang, Yi Jiang, Hong Luo, Rui Zhou, Kui Xiao
Determination of the best surgical strategy for thoracic esophageal resection concurrent with double aortic arch using a three-dimensional model: a case report
Kenji Hamada, Yusuke Taniyama, Yoshiyuki Yashima, Yohei Ozawa, Toshiaki Fukutomi, Hiroshi Okamoto, Chiaki Sato, Michiaki Unno, Takashi Kamei
Successful outcome of neoadjuvant PD-1 blockade, VEGFR-2 inhibitor plus chemotherapy for potentially unresectable esophagogastric junctional squamous cell carcinoma: a case report
Kai-Bo Chen, Zhi-Wei Wu, Yi Huang, Mu-Xing Kang, Le-Le Lin, Shan-Shan Jiang, Hui Zhang, Ya-Jing Huang, Li Chen
Intracranial complete response to toripalimab and anlotinib in a patient with recurrent brain metastases of small cell lung cancer after failure of second-line maintenance therapy: a case report
Fengxiang Huang, Jiaqi Tang, Jiaojiao Lou, Qilong Wang, Kai Ma, Ruiping Qiao, Jiming Si, Yan Kang, Hongjie Chen, Jingjing Mei, Huanqin Wang, Yuanhua Liu, Lijun Miao
Advanced lung adenocarcinoma (LUAD) patient with EGFR mutations benefited from multiline combination targeted therapies after osimertinib (AZD9291) resistance: a case report
Jingyu Chen, Xueqi Zhao, Jinlin Wang, Fangfang Liu, Linli Zhang, Yuan Chen, Qian Chu
Leptomeningeal metastasis from de novo metastatic nasopharyngeal carcinoma: a case report
Xin Zhang, Xiaolei Shu, Bin Long
Advanced non-small cell lung cancer treated with palliative systemic therapy complicated by calvarial metastasis: a case report
Sapan Patel, Brittany Zaita, Adityabikram Singh, Vivas Tatachar, Sunaina Dias, Emma Fattakhov, Gurjinder Kaur
Primary mesenchymal chondrosarcoma of the adult lumbar spine: a case report and review of the literature
Maoqiang Lin, Haiyu Zhou, Xiaobo Zhang, Yicun Hu, Taowen Guo, Jintao Shi
Rare malignant primary spinal intradural extramedullary mesenchymal chondrosarcoma: a case report and literature review
Yunda Wang, Xin Meng, Wenqing Liu, Haocong Wang, Tao Xin
A recurrent inflammatory myofibroblastic tumor patient with two novel ALK fusions: a case report
Xiumei Xu, Ling Li, Yaxuan Zhang, Fanfan Meng, Hongmei Xie, Ruiqi Duan
Perioperative management of intrahepatic cholangiocarcinoma patients with hereditary coagulation factor V deficiency: a case report and literature review
Jianlin Lai, Junyi Wu, Yangyang Huang, Hui Cheng, Yannan Bai, Funan Qiu
Ovarian metastases from ALK-positive lung adenocarcinoma: a case report and review of the literature
Huixin Li, Yan Chen, Yingchun Wang, Lin Zhou, Zhongfu Tian, Mengyu Liu, Yang Li, Hanzi Xu, Wangfei Wu, Zhen Gong
Radiation induced lung injury (RILI) after postoperative intensity modulated proton therapy (IMPT) in a patient with stage III locally advanced lung adenocarcinoma: a case report
Zixin Hu, Jiabin Zheng, Ying Xiong, Kexin Tan, Xu Zhang, Yixuan Yu, Huijing Dong, Xingyu Lu, Guangying Zhu, Huijuan Cui
CT and MRI findings of intracranial extraskeletal mesenchymal chondrosarcoma—a case report and literature review
Jixiang Chu, Huan Ma, Yao Wang, Kun Li, Chengde Liao, Yingying Ding
Pembrolizumab for treatment of a male with primary mediastinal choriocarcinoma: a case report
Weiyu Pan, Jun Hou
Endometrial stromal sarcoma metastatic to the inferior vena cava: a case report and literature review
Ying Zhang, Zhiyong Wei, Jia Yan, Keliang Xie, Zhiqiang Wang
Intradural spinal seeding metastasis of clival chordoma: a case report
Xiaohai Liu, Mingchu Li, Ge Chen
Primary hepatic paraganglioma mimicking hepatocellular carcinoma: a case report
Li Li, Pei-Pei Fei, Zhi-Yun Guo, Juan Wang, Ze-Ya Pan, Cheng-Gang Xu, Jian Huang

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Magnetic resonance imaging of pancreatic malignancy
Mellena D. Bridges
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Advances on immunotherapy in breast cancer
Kanthi Athreya, Sonia Ali
Targeting the folate receptor for the treatment of ovarian cancer
Robert J. Lutz
Computational resources for radiomics
Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang


Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich


Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades


Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin


Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
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Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
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Original Articles

Third generation gold nanoplatform optimized for radiation therapy
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Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
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Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report

Original Article

Review Article