Article Abstract

Imaging of T cells in patients with recurrent glioblastoma

Authors: Sanjiv Sam Gambhir

Abstract

Immunotherapies including CAR-T cell therapies offer some new hope for treatment of various cancers. As with all therapies, individual patient optimization would be of great help to maximize the chance of success. Issues including: (I) earlier detection of aggressive cancers; (II) staging of the cancer to determine different sites of tumor involvement; (III) determination of likelihood of benefit from a given therapy; (IV) monitoring during or soon after completion of therapy to determine non-responders so that one can change to another therapeutic strategy early; (V) monitoring for recurrence of the cancer after initial treatment, are all in need of careful attention. For each of these approaches both in vitro diagnostics and in vivo imaging offer potential solutions for cancer diagnosis and management.