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New Impact Factor for Translational Cancer Research: 0.986

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2019 citation year: 0.986. More >>

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others),... More >>

Implementation of transparent peer review at Translational Cancer Research

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a... More >>

Original Article

Prognostic value of combined preoperative prognostic nutritional index and neutrophil to lymphocyte ratio in esophageal squamous cell carcinoma
Jiandong Zhang, Yan Zhang, Xinshuang Yv, Meijuan Song, Fang Zhang, Xiufang Tian, Yajuan Lv
The Prognostic roles of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in gastrointestinal stromal tumours: a meta-analysis
Zhe-Wei Wei, Wei-Bin Huang, Dong-Jie Yang, Yu-Jie Yuan, Yu-Long He, Chang-Hua Zhang
Clinical features, treatment and risk factors for interstitial pneumonia in B-cell non-Hodgkin lymphoma patients
Cong Li, Fangxiao Lu, Tao Lei, Haifeng Yu, Haiyan Yang
Administration of amifostine in the stage of remission induction can benefit the patients with hematological malignancy in autologous stem cell transplantation: a retrospective study
Min Wu, Kefei Wu, Pingping Chen, Pei Li, Yanhui Xie
Development and validation of a nomogram for predicting survival in patients with non-metastatic primary adenocarcinoma of the bladder
Dong-Dong Yu, Hui Dong, Wei-Kang Chen, Kun Chen, Zhi-Gang Wu, Cheng-Di Li, Jian Cai, Yun-Bei Xiao
Robot-assisted distal pancreatectomy improves spleen preservation rate versus laparoscopic distal pancreatectomy for benign and low-grade malignant lesions of the pancreas
Yabo Jiang, Kailian Zheng, Shichao Zhang, Zhuo Shao, Peng Cheng, Yijie Zhang, Gang Jin, Tianlin He
The expression of Fibulin-3 in ovarian cancer and its relationship with prognosis
Xinmei Wang, Lisha Zhu, Jingxian Wu, Yong Zhao
Prognosis of early stage pulmonary mucinous adenocarcinoma with different treatments
Jinyuan Liu, Shijiang Zhang, Jinhua Luo
hsa-miR-195-5p inhibits cell proliferation of human thyroid carcinoma cells via modulation of p21/cyclin D1 axis
Dexin Liu, Ping Li, Xiaodong Wang, Wei Wang
Elevated carbohydrate antigen 125 post-operation as a prognostic marker in gastric cancer patients with stage II–III
Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Jieer Ying
Recombinant virus expressing hIFN‐λ1 (rL‐hIFN‐λ1) has important effects on endoplasmic reticulum stress, autophagy and apoptosis in small cell lung cancer
Yulan Yan, Xiaomei Shao, Wenlu Gu, Anwei Zhang, Xuefeng Bu, Bing Liang
COL4A family: potential prognostic biomarkers and therapeutic targets for gastric cancer
Xi Zeng, Hao-Ying Wang, Yu-Ping Wang, Su-Yang Bai, Ke Pu, Ya Zheng, Qing-Hong Guo, Quan-Lin Guan, Rui Ji, Yong-Ning Zhou
Integrated analysis identifies low microRNA-215 expression as associated with a poor prognosis of patients with colorectal cancer through the IKβ-α signaling pathway
Zhuo Wang, Xin Jiang, Qing Li, Yufen Jin, Xingxiang Liu, Fang Wang, Yong Mao, Dong Hua
Application of metagenomic next-generation sequencing technology for difficult lung lesions in patients with haematological diseases
Nana Liu, Jianying Kan, Naihao Yu, Wenbin Cao, Jie Cao, Erlie Jiang, Jing Feng
A high monocyte-to-lymphocyte ratio predicts poor prognosis in patients with radical cystectomy for bladder cancer
Heng Shi, Keyi Wang, Jing Yuan, Weipu Mao, Zonglin Wu, Qunlong Liu, Jinbo Xie, Bo Peng
Expression of combined interference of slug and FoxC2 in endometrial carcinoma and its clinicopathological relationship
Qing Zhu, Mingyang Tang, Ligao Wu
ERH overexpression is associated with decreased cell migration and invasion and a good prognosis in gastric cancer
Ji-Ho Park, Miyeong Park, Sun Yi Park, Young-Joon Lee, Soon-Chan Hong, Eun-Jung Jung, Young-Tae Ju, Chi-Young Jeong, Ju-Yeon Kim, Gyung Hyuck Ko, Young-Sool Hah, Sang-Ho Jeong
Prognostic factors, treatment, and outcomes in combined small cell lung cancer: a SEER survey from 2004 to 2015
Long Xu, Guanzhong Zhang, Shuxi Song, Zhendong Zheng
Risk assessment model and nomogram established by differentially expressed lncRNAs for early-stage lung squamous cell carcinoma
Zhulin Wu, Chensheng Ouyang, Lisheng Peng
PD-1 inhibitor combined with apatinib for advanced gastric or esophagogastric junction cancer: a retrospective study
Qing Wei, Xing Yuan, Jingjing Li, Qi Xu, Jieer Ying
Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1
Zhengfeng Xu, Xiaoxiao Zhou, Jiajun Wu, Xu Cui, Minghui Wang, Xiuhui Wang, Zhenchao Gao
Radical local treatment for stage IV non-small cell lung cancer in older adults: a propensity-score matched analysis of the SEER database
Chenhui Qiu, Shaotang Zhang, Hualiang Jin, Xiaoqin Zhang, Jian Ye
shRNA targeting PLK1 inhibits the proliferation and invasion of nasopharyngeal carcinoma cells
Yan Zhou, Chu Wu, Bingxue Liu, Juan Zhu, Yating Zhong, Yuqing Yuan, Yue Huang, Yunlian Tang
B7-H7 is a prognostic biomarker in epithelial ovarian cancer
Yuanyuan Fu, Yun Ding, Juan Liu, Xiao Zheng, Wei Wei, Yaoyu Ying, Changping Wu, Jingting Jiang, Jingfang Ju
Application of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma related to hepatitis B virus: comparison with traditional one-stage right hepatectomy
Junwei Zhang, Yiyao Xu, Huayu Yang, Hanchun Huang, Jin Bian, Shitao Jiang, Xinting Sang, Yilei Mao, Haitao Zhao, Shunda Du, Haifeng Xu, Yongchang Zheng, Tianyi Chi, Xin Lu
A microRNA delivery carrier for hepatic carcinoma therapy using layer-by-layer self-assembled mesenchymal stem cells
Chunmin Li, Xin Li, Fengsheng Li, Dawei Wang, Jin Wang, Tao Yan, Bo Sun, Hualiang Ren
Selective estrogen receptor modulator with estrogen does not affect the proliferation and apoptosis of uterine leiomyoma cells
Shu-Lan Lv, Rui Wang, Xue Xue, Lan-Bo Zhao, Xiao-Qian Tuo, Si-Jia Ma, Dong-Xin Liang, Yi-Ran Wang, Xue Feng, Qing Li, Qi Wang, Lu Han, Qi-Ling Li
Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis
Wenting Wang, Guang Li
Total superior vena cava reconstruction guided by preoperative three-dimensional (3D)-computed tomography bronchography and angiography
Zhenyang Zhang, Jiangbo Lin, Tianci Chai, Mingqiang Kang, Wenhua Chen, Hanfan Qiu, Zhiqiang Zou, Lei Gao, Chuangcai Yang, Jiafu Zhu
Knockdown of ferritin heavy chain (FTH) inhibits the migration of prostate cancer through reducing S100A4, S100A2, and S100P expression
Cuixiu Lu, Huijun Zhao, Chenshuo Luo, Ting Lei, Man Zhang
Long-term survival of patients with anaplastic thyroid cancer after multimodal treatment
Haejun Lee, Soo Young Kim, Seok-Mo Kim, Ho-Jin Chang, Yong Sang Lee, Cheong Soo Park, Hang-Seok Chang
Tumor mutation burden predicts response and survival to immune checkpoint inhibitors: a meta-analysis
Linghong Wan, Zhi Wang, Jinmin Xue, Huaju Yang, Yuxi Zhu
Survival impact of delaying postoperative chemoradiotherapy in newly-diagnosed glioblastoma patients
Maochen Zhang, Fei Xu, Weiqiong Ni, Weixiang Qi, Weiguo Cao, Cheng Xu, Jiayi Chen, Yunsheng Gao
Identification of key biomarkers and potential signaling pathway associated with poor progression of gastric cancer
Yangzhi Hu, Zhili Hu, Hui Ding, Yuan Li, Xiaoxu Zhao, Mingtao Shao, Yunlong Pan
Increased efficacy of gefitinib on cisplatin-resistant wild-type epidermal growth factor receptor non-small cell lung cancer cells
Amin Li, Weiya Cao, Xueke Liu, Yinci Zhang, Yongfang Ma, Ruyue Xu, Xiaolong Tang
Laparoscopic versus open left hemihepatectomy for hepatocellular carcinoma: a propensity score matching analysis
Yong Yi, Jialei Weng, Chenhao Zhou, Gao Liu, Ning Ren
TNFRSF12A and a new prognostic model identified from methylation combined with expression profiles to predict overall survival in hepatocellular carcinoma
Yu Fang, Lin Xiang, La-Mei Chen, Wei-Juan Sun, Yu-Jia Zhai, Yu-Chen Fan, Kai Wang
Association between clinicopathological features and prognosis significance of PD-L1 expression in small cell lung cancer patients: a systemic review and meta-analysis
Zongtao Hu, Lin Lu, Zhenle Fei, Donglai Lv
A newly improved POSSUM scoring system for prediction of morbidity in patients with pancreaticoduodenectomy
Zhi-Lei Zhang, Lian Chen, Li Peng, Sheng-Chao Li, Peng Guo, Meng Zhang
Construction of a potential microRNA, transcription factor and mRNA regulatory network in hepatocellular carcinoma
Ning Li, Shaotao Jiang, Jiewei Shi, Rongdang Fu, Huijie Wu, Minqiang Lu
Circulating miR-17 as a promising diagnostic biomarker for lung adenocarcinoma: evidence from the Gene Expression Omnibus
Erna Jia, Na Ren, Rongkui Zhang, Changyu Zhou, Jinru Xue
Super-enhancers modulate interleukin-6 expression and function in cancers
Yuhua Bao, Yingcheng Wu, Baorui Tao, Rong Sun, Ting Lin, Yijian Zheng, Xiaolin Zhu, Haoliang Shen, Weichang Chen, Yihui Fan
Neutrophil-lymphocyte ratio as a prognostic factor for stereotactic body radiotherapy treatment of metastatic liver tumors
Xuyun Xie, Jingjing Shan, Xuan Zhou, Hai Liu, Xiaonan Sun
Protein tyrosine phosphatase receptor type delta (PTPRD) suppresses the expression of PD-L1 in human hepatocellular carcinoma by down-regulating STAT3
Qiuhua Meng, Jing Tian, Feizhang Qin, Xuejing Huang, Dan Zhu, Bangde Xiang, Min Dong
Serum zinc level and tissue ZIP4 expression are related to the prognosis of patients with stages I–III colon cancer
Xin Wu, Han Wu, Liyang Liu, Guanghui Qiang, Jianwei Zhu
Expression of biogenesis of ribosomes BRX1 is associated with malignant progression and prognosis in colorectal cancer
Jianxin Ge, Xiaoli Huang, Ping Wang, Cuihua Lu
Clinicopathological significance of Sox10 expression in triple-negative breast carcinoma
Linfang Jin, Chenglin Qin, Xiaowei Qi, Tingting Hong, Xiaodong Yang, Xun Zhu
Overexpression of UBE2M through Wnt/β-Catenin signaling is associated with poor prognosis and chemotherapy resistance in colorectal cancer
Jianmin Xu, Guoqiang Lv, Binghua Xu, Bin Jiang
MicroRNA-153-3p sensitizes melanoma cells to dacarbazine by suppressing ATG5-mediated autophagy and apoptosis
Shaowei Hou, Minfang Guo, Haiying Xi, Lianqing Zhang, Ailing Zhao, Heng Hou, Wuning Fang
FAM172A affects cell proliferation and apoptosis not by targeting β-tubulin in HepG2 cells
Ai-Min Xu, Chuan-Jiang He, Zureguli Tuerxun, Abuduaini Anikezi

Editorial on Energy Balance, Aging, Obesity, and Cancer1

Apocalyptic horsemen of geriatric oncology
Nathan A. Berger

Disclosure:

1. The series “Energy Balance, Aging, Obesity, and Cancer” was commissioned by the editorial office, Translational Cancer Research without any sponsorship or funding. Nathan A. Berger served as the unpaid Guest Editor for the series.

2. The series “Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy” was commissioned by the editorial office, Translational Cancer Research without any sponsorship or funding. Jia Wei served as the unpaid Guest Editor for the series.

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Magnetic resonance imaging of pancreatic malignancy
Mellena D. Bridges
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Advances on immunotherapy in breast cancer
Kanthi Athreya, Sonia Ali
Targeting the folate receptor for the treatment of ovarian cancer
Robert J. Lutz
Computational resources for radiomics
Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.



Original Article


Review Article