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Original Article

Bioinformatics-based identification of differentiated expressed microRNA in esophageal squamous cell carcinoma
King Wai Lau, Haikang Zeng, Hengrui Liang, Xi Su, Jieling Ma, Shuai Wen, Jin Li
Potential roles of microRNA in levonorgestrel-treated uterine leiomyoma cells
Huiyuan Ma, Xiaoyan Shi, Ziyi Fu, Xiaoli Wu, Yushuang Huangfu, Pengfei Xu, Xin Zeng, Juan Xu, Hongjie Ruan, Qing Xu
Plasma fibrinogen as prognostic predictor in patients with metastatic renal cell carcinoma receiving target therapy
Lihe Wang, Wen Cai, Wen Kong, Jin Zhang, Yonghui Chen, Jiwei Huang, Yiran Huang
Germline polymorphisms (SNPs) to predict toxicity and efficacy in FLOT-treated patients with locally advanced gastroesophageal junction or gastric adenocarcinoma—data from the NeoFLOT study
Christoph Schulz, Wu Zhang, Heinz-Josef Lenz, Jens Neumann, Frank Kullmann, Volker Kunzmann, Martin Fuchs, Volker Heinemann, Julian Walter Holch, Sebastian Stintzing
Diagnostic values of serum tumor markers CA72-4, SCCAg, CYFRA21-1, NSE, AFU, CA125, CA19-9, CEA and FER in nasopharyngeal carcinoma
Yong-Fei Tang, Wen Li, Jing-Ping Yuan, Ya-Bing Huang, Hong-Lin Yan, Lin Liu, Xiang-Pan Li, Ming Wang
To inhibit growth and migration of glioma cells through down regulation glucose metabolism related to aquaporin (AQP)-1
Xiangming Liu, Jinglong Chen, Jinqian Zhang
Preoperative chemoradiation may be more effective for esophageal squamous cell carcinoma compared with adenocarcinoma: results from 15 randomized controlled trials of 2,250 patients
Wen-Juan Ma, Qiu-Ning Zhang, Shu-Zhen Shi, Xiao-Ying Zhang, Ye Zhao, Jin-Hui Tian, Xiao-Hu Wang
LncRNA NKILA suppresses colon cancer cell proliferation and migration by inactivating PI3K/Akt pathway
Jian Huang, Lingfeng Zhao, Wei Chen, Jian Duan, Dibesh Shrestha, Ruize Zhou, Xiaoyu Tuo, Zhu Zhu
AZT sensitizes hepatocellular carcinoma cells to As2O3 by upregulating the arsenic transporter aquaglyceroporin 9
Mei Wang, Yongjuan Liang, Chuan Zhao, Xiuyue Wang, Che Chen
Increased γ-glutamyl transferase positively contributed to the poor prognosis in lung cancer patients
Jing Jing Ran, Ruixin He, Qiang Yu, Limei Kang, Yaoqi Fu, Cong Bo, Li Zhang
Evaluation and predictive factors analyses for patient-self-reported depression, anxiety and quality of life in patients with metastatic renal cell carcinoma underwent interferon-α treatment: a prospective cohort study
Yanjie Wang, Bingbing Song, Yuling Zhang, Haibo Li
Prognostic value of serum apolipoprotein A-I in locally advanced cervical squamous cell carcinoma treated with radical chemoradiotherapy
Hui Chang, Kai Chen, Yan-Zhu Lin, Ya-Lan Tao, Yang Liu, Xin-Ping Cao, Wei-Jun Ye
Exosomal miR-196b-5p is a potential diagnostic marker for colorectal cancer with metachronous liver metastasis
Jinhua Wu, Bihua Lin, Shuaishuai Yu, Yingjie Chen, Jianyong Chen, Caihong Li, Xiangyong Li, Xin Zhang, Yangfang Liang, Keyuan Zhou, Jincheng Zeng
Predictive implications of genomic microarray for the diagnosis of prostate cancer metastasis following radical surgery
Zhihua Zhang, Yanhui Su, Fei Luo, Jian Li
Common and specific genes in ovarian clear cell carcinoma and serous carcinoma by gene expression analysis
Wenjiao Cao, Lihua Wang
In-vitro evaluation of HSP27 inhibitors function through HER2 pathway for ovarian cancer therapy
Laila Jaragh-Alhadad
Real-world response of patients with locally advanced pancreatic adenocarcinoma to high intensity focused ultrasound treatment: a single-center, observational study in China
Congye Wu, Xinmei Wu, Huanyu Zhao, Dongying Gu, Xiaowei Wei, Cuiju Tang, Jinfei Chen
The role of celecoxib for colorectal cancer treatment: a systematic review
Xiaohan Zhou, Xiuyun Wang, Yaqin Zhao, Cheng Yi
The expression of CD74 and macrophage migration inhibitory factor protein is upregulated in hepatitis B virus-related hepatocellular carcinoma
Mingzhu Lu, Yun Xu, Guangzhao He, Qian Liu, Jing Zhu, Changsong Zhang
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Multiplexed immunoassay-based serum cytokine profiling for potential prognosis predictors in patients with metastatic breast cancer
Hongyan Huang, Yanbin Zhang, Sha Li, Jing Zhao, Xiaoli Wang, Xinna Zhou, Jun Ren
Exopolysaccharides from an Ophiopogon japonicus endophyte inhibit proliferation and migration in MC-4 human gastric cancer cells
Wenjun Xu, Yongle Yang, Youguang Yang, Zhongxia Lu, Qunying Lu, Yitao Chen
MicroRNA-1275 targets PKCα to depress proliferation and the invasion of pancreatic cancer cells
Lei Yuan, Meng-Yao Ji, Cheng Lu, Pingxiao Huang, Wei-Guo Dong
The clinical effect of β-elemene-assisted radiochemotherapy in the treatment of esophageal cancer: a systematic review and meta-analysis
Chenxi Li, Yiying Zeng, Nana Zhang, Bingtao Zhai, Chao Zhang, Yao Zhu, Zhaowu Zeng, Tian Xie
Intensive patients’ care program ameliorates anxiety and depression, and sustained anxiety correlates with worse overall survival in renal cell carcinoma patients underwent radical nephrectomy
Bingbing Song, Yuling Zhang, Yanjie Wang, Xushu An
ARF-derived peptide sensitizes ovarian cancer cells to Cisplatin
Jinhua Zhou, Yunfei Wang, Yun Qian, Xinran Wang, Ting Liu, Wen Di
Prognostic and clinicopathological roles of long non-coding RNA XIST in human cancers: a meta-analysis
Liang Shen, Changzhong Li, Ming Liu, Deying Wei, Qin Chang, Jing Cui
Establishment and characterization of a novel cell line derived from type AB thymoma
Qiangling Sun, Zhitao Gu, Lei Zhu, Xiaohua Yang, Weigang Zhao, Shubin Guan, Wentao Fang
Abnormally differentiated bone marrow mesenchymal stem cells develop into tumors in rats
Hongxia Yuan, Shiqi Liao, Jiayu Zeng, Xiaojuan Huang, Jieyu Zhang, Jing Zhao, Yuxian Wang, Hong Zhang, Xiaoqi Wang, Shidong Liao, Wenru Tang, Zhengli Wei, Caiping Tian, Rong Yang, Fang Liu, Hongyun Guo, Yongdong Zhang
Expression of ATP transporters is associated with histologic regression of rectal carcinoma after neoadjuvant chemoradiotherapy
Duck-Woo Kim, Hyun-Chul Kim, Bo Hyung Kim, Myung Jo Kim, Eun Shin
Intra-operative motor function preservation for resection of primary motor cortex meningioma
Hailiang Tang, Feng Xu, Liqing Lin, Hongda Zhu, Lingyang Hua, Shihai Luan, Qing Xie, Ye Gong
Therapeutic effects of different regimens for induction therapy in elderly patients more than 50 years old with newly diagnosed acute myeloid leukaemia
Junmei Liu, Liang Zhong, Juanjuan Yao, Pengqiang Zhong, Zhen Yuan, Dongdong Liu, Lianwen Li, Lu Liu, Yi Zhao, Shifei Yao, Min Chen, Beizhong Liu
Phosphorylated retinoblastoma is a biomarker of overall disease control and better progression-free survival of recurrent epithelial ovarian cancer patients treated with second-line topoisomerase inhibitor CPT-11 chemotherapy
Kui Jiang, Guangyan Gao, Lulu Yao
Human herpesvirus 6 U94 suppresses tumor cell proliferation and invasion by inhibiting Akt/GSK3β signaling in glioma
Wenqing Jiang, Lingyun Li, Huamin Tang, Bin Gu, Dongju Feng, Feng Zhou, Yingxia Liu, Xianyi Xu, Yun Chen, Kun Yao, Weixing Hu
A novel insight in the diagnosis of peripheral primitive neuroectodermal tumors: a retrospective analysis of 23 patients
Tao Li, Hongsheng Li, Haitao Zhao, Wenlan Zhou, Quanshi Wang, Kongzhen Hu, Shun Huang, Hubing Wu, Lilan Fu
COPB2-shRNA suppresses cell growth and induces apoptosis of STAD SGC-7901 cells via inactivation of p38 MAPK/Smad2/Chk1/2 as an oncogene
Hailong Li, Yao-Hui Song, Zheng-Ping Du, Xueyan Zhang, Cai-Xia An, Yonghua Hu, Yihong Tian, Zhiwei Wu, Hongyan Wu, Che Chen

Review Article

Critical role of KRAS mutation in pancreatic ductal adenocarcinoma
Zhiyao Fan, Kun Fan, Chao Yang, Qiuyi Huang, Yitao Gong, He Cheng, Kaizhou Jin, Chen Liu, Quanxing Ni, Xianjun Yu, Guopei Luo
Clinical significance of CXCL13/CXCR5 axis in human cancers
Dawei Zhu, Wenfeng Ye, Jingting Jiang
Multiple keratoacanthoma centrifugum marginatum—a case report and systematic review
Yiman Wang, Wenling Zhao, Yueping Zeng, Li Li, Hongzhong Jin

Letter to the Editor

Cytotoxic effect of Artesunate on myeloid leukemia cell lines through up-regulating miR-29c expression
Cui-Yun Dou, Lu-Lu Liu, Feng Li, Lei Liu, Cui-Ling Wang, Li-Na Wang, Hai-Hua Wang, Hao Zhang, Ming-Tai Chen

Erratum

Erratum to MiR-875-5p inhibits hepatocellular carcinoma cell proliferation and migration by repressing astrocyte elevated gene-1 (AEG-1) expression
Caixia Hu, Shichang Cui, Jiasheng Zheng, Tian Yin, Junsheng Lv, Jiang Long, Wenwen Zhang, Xun Wang, Shoupeng Sheng, Honghai Zhang, Yu Sun, Hongguang Wang, Cong Li

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

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