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Announcement more

Translational Cancer Research (TCR) is going to publish monthly starting in September 2019!

Translational Cancer Research (TCR) is going to publish monthly starting in September 2019! More >>

New Impact Factor for Translational Cancer Research: 1.07

New Impact Factor for Translational Cancer Research: 1.07 More >>

TCR Annual Report (2018)

TCR Annual Report (2018) More >>

Meet the Professor more

Theresa L. Whiteside: if you believe you are correct, stay with it even if no one initially... More >>
Maria G. Castro: science is a highly collaborative endeavor that transcends different barriers! More >>
Louis Dubeau: putting aside biases and validating accustomed dogmas make successful scientists More >>

Original Article

Efficacy of salvage radiotherapy for relapsed/refractory diffuse large B-cell lymphoma
Shu-Bei Wang, Jia-Yi Chen, Wei-Li Zhao, Youlia M. Kirova, Wei-Guo Cao
Carcinoembryonic antigen in pleural effusion of patients with lung adenocarcinoma: a predictive marker for EGFR mutation
Yan-Ling Lv, Hong-Bing Liu, Dong-Mei Yuan, Li Zhou, Shu-Xian Jin
Efficacy of re-resection versus radiofrequency ablation for recurrent Barcelona Clinic Liver Cancer stage 0/A hepatocellular carcinoma (HCC) after resection for primary HCC
Xieling Yin, Tianqi Hua, Chi Liang, Zhong Chen
Competitive endogenous RNA network identifies four long non-coding RNA signature as a candidate prognostic biomarker for lung adenocarcinoma
Jing Hu, Tonglian Wang, Qiang Chen
The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors
Yang Ge, Yi-Kun Kang, Li Dong, Li-Hong Liu, Guang-Yu An
Survival benefit of radiotherapy in metastatic esophageal cancer: a population-based study
Xiangpan Li, Huibo Zhang, Xuemei Jia, Liming Xu, Huali Liu, Liang Chen, Qibin Song, Zhouguang Hui
Overexpression of UHRF1 and its potential role in the development of invasive ductal breast cancer validated by integrative bioinformatics and immunohistochemistry analyses
Yichen Yang, Guanjun Liu, Lifang Qin, Li Ye, Fangheng Zhu, Ying Ying
LncRNA-MIR17HG mediated upregulation of miR-17 and miR-18a promotes colon cancer progression via activating Wnt/β-catenin signaling
Guangwen Yuan, Bin Liu, Wenqian Han, Daqi Zhao
Lung cancer in young patients: tumour characteristics and treatment in an Irish population
Sarah Cullivan, Sarah Ni Mhaolcatha, Michael T. Henry, Nazri Kaderi Muhammad, William Mullally, Richard M. Bambury, Louise Burke, Marcus P. Kennedy
Construction and analysis of lncRNA-associated ceRNA network identified potential prognostic biomarker in gastric cancer
Jingfeng Peng, Yimiao Zhu, Xin Dong, Xiaoming Mao, Yanbo Lou, Yunchuan Mu, Dan Xue, Huijiang Zhou
Expression of HER-2 in surgical specimen and biopsy as a biomarker of metastasis in patients with osteosarcoma: a meta-analysis
Jian Zhou, Wanchun Wang, Qian Yan, Yingquan Luo
Inflammation-based markers can predict the prognosis of geriatric patients with metastatic colorectal cancer receiving first-line chemotherapy
Guifang Guo, Xiuxing Chen, Xiuyu Cai, Yanfeng Chen, Haohua Wang, Lei Fan, Long Bai, Huijuan Qiu, Bei Zhang
Risk of breast cancer based on thermal tomography characteristics
Si Sun, Xin Yu, Juanjuan Li, Zhiyu Li, Shan Zhu, Lijun Wang, Juan Wu, Kaiyang Li, Qi Wu, Shengrong Sun
Uncovering the potential miRNAs and mRNAs in follicular variant of papillary thyroid carcinoma in the Cancer Genome Atlas database
Meiye Li, Baochang Zhao, Wei Qu, Zongjing Zhang, Zhaoshun Jiang
Sideroflexin1 as a novel tumor marker independently predicts survival in lung adenocarcinoma
Qijiu Chen, Rong Wang, Jianyong Zhang, Liang Zhou
The value of hysteroscopy and transvaginal ultrasonography in the diagnosis of endometrial hyperplasia: a systematic review and meta-analysis
Yingsha Yao, Weiguo Lv, Xing Xie, Xiaodong Cheng
Survival-based bioinformatics analysis to identify hub genes and key pathways in non-small cell lung cancer
Chunliang Liu, Yu Chen, Yuqi Deng, Yu Dong, Jixuan Jiang, Si Chen, Wenfeng Kang, Jiong Deng, Haipeng Sun
Efficacy and safety of CalliSpheres® drug-eluting beads transarterial chemoembolization in patients with secondary liver cancer: a preliminary result from CTILC study
Xia Wu, Shihong Ying, Jing Huang, Changsheng Shi, Jiansong Ji, Zhiyi Peng, Guanhui Zhou, Zhichao Sun, Junhui Sun, Wenqiang Yu, Wenhao Hu, Xin Zhang, Jian Zhou, Guoliang Shao, Zhihai Yu, Qinming Hou, Wenjiang Gu, Tiefeng Li, Xiaoxi Xie, Guohong Cao, Haijun Du, Dedong Zhu, Huanhai Xu, Jun Han, Wenbin Ji, Jian Fang, Ling Li, Jiaping Zheng, Jun Luo, Yutang Chen, Tingyang Hu, Hongjie Hu, Xiaohua Guo
Clinicopathologic characteristics and survival analysis in stage IVB cervical cancer with hematogenous metastasis
Haoran Li, Yufei Yang, Hongyu Zhou, Fei Liu, Mengjiao Li, Lihua Chen, Xiaohua Wu, Xi Cheng
The MEK inhibitors enhance the efficacy of sorafenib against hepatocellular carcinoma cells through reducing p-ERK rebound
Wanting Hou, Hongwei Xia, Sheng Zhou, Zhenhai Fan, Huanji Xu, Qiyong Gong, Yongzhan Nie, Qiulin Tang, Feng Bi
The role of prostaglandin E receptor 2 and epidermal growth factor receptor in esophageal squamous cell carcinoma patients with (pN+) regional lymph node metastasis
Hui-Qin Luo, Yi-Fu He, Ying Yan, Shu-Sheng Wu, Xiao-Xiu Hu, Li-Hong Ke, Jia-Yu Niu, Hui-Min Li, Hui-Jun Xu
Validation of the diagnostic efficiency of folate receptor- positive circulating tumor cells in lung cancers: a prospective observational study
Jingbo Liu, Min Han, Hongyu Huang
Overexpression of CASC19 indicates poor prognosis and facilitates proliferation, migration and invasion in colorectal cancer
Jiang Zhao, Cong Li, Shiqing Chen, Ye Xu, Fangqi Liu
Pooled analysis of the clinical benefit of cyclooxygenase-2 inhibitors combined with chemotherapy in advanced non-small cell lung cancer
Wei Zheng, Zhi-Min Liao, Yan Fu, Ya-Peng Wu, Qiong Zhang
HSP27 promotes epithelial-mesenchymal transition through activation of the β-catenin/MMP3 pathway in pancreatic ductal adenocarcinoma cells
Zehong Fang, Wenjin Liang, Laibang Luo
Multi-omics analysis reveals the BRCA1 mutation and mismatch repair gene signatures associated with survival, protein expression, and copy number alterations in prostate cancer
Tzu-Hung Hsiao, Yu-Chiao Chiu, Yu-Hsuan Joni Shao
PDZRN4-mediated colon cancer cell proliferation and dissemination is regulated by miR-221-3p
Xiaojian Liu, Chungen Xing
Role of PI3K/Akt pathway in Benzidine-induced proliferation in SV-40 immortalized human uroepithelial cell
Demao Ding, Zhiqi Liu, Li Zhao, Hao Geng, Zhaofeng Liang, Dexin Yu
c[RGDyk]-coated liposomes loaded with adriamycin and miR-21 mimics inhibit the growth of hepatoma cell line SMCC-7721 via up-regulating Bax and p53
Xiaoyong Wei, Xiaolong You, Jianlong Zhang, Cuncai Zhou
IL-35 inhibits CD8+ T cells activity by suppressing expression of costimulatory molecule CD28 and Th1 cytokine production
Hua Jiang, Ting Zhang, Mao-Xiao Yan, Wei Wu
Prognostic values of platelet-associated indicators in advanced breast cancer
Yu-Jie Lu, Meng-Ting Cui, Zhan-Wen Liang, Wen-Jie Wang, Min Jiang, Meng-Dan Xu, Meng-Yao Wu, Meng Shen, Wei Li, Yuan Gao, Lian Lian, Wei-Ming Duan
Palliative bypass surgery in elderly patients with resectable periampullary carcinoma: a report of 45 cases
Zhao-Bin He, Min Jiang, Wei-Bo Niu, Cheng Peng, En-Yu Liu, Chao Gao, Jiu-Zheng Sun, Chuan-Zong Zhao, Jian-Guo Hong, Hui-Jie Gao, Rui Zhao, Jun Niu
Detection of circulating stage III–IV gastric cancer tumor cells based on isolation by size of epithelial tumor: using the circulating tumor cell biopsy technology
Rong Lu, Qiang Chen, Xiaoying Liu, Songfei Shen, Zhangchi Pan, Chunmei Shi
The expression profile of RNA sensors in colorectal cancer and its correlation with cancer stages
Liangmei He, Fei Wang, Hongbo Tian, Yuan Xie, Lu Xie, Zhiping Liu
Five tumor-associated autoantibodies expression levels in serum predict lung cancer and associate with poor outcome
Shaolei Li, Yuanyuan Ma, Ying Xiong, Panpan Zhang, Xiao Wang, Yong Wang, Yue Yang
Alpha-actinin 4 and tumorigenesis of hepatocellular carcinoma
Guidong Wang, Yuhua Li, Bin Tang, Qing Yu
Stereotactic body radiation therapy or surgery for stage I–II non-small cell lung cancer treatment?—outcomes of a meta-analysis
Qiuning Zhang, Lihua Shao, Jinhui Tian, Ruifeng Liu, Yichao Geng, Yiran Liao, Hongtao Luo, Long Ge, Shuangwu Feng, Xiaohu Wang, Zhen Yang
Association of epidermal growth factor receptor protein expression with histopathological and clinical parameters in carcinoma of the larynx
Chittibabu Vatte, Ali M. Al-Amri, Cyril Cyrus, Shahanas Chathoth, Abdulla Alsulaiman, Ahmed Al Sayyah, Amein Al-Ali
Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis
Yi-Kun Kang, Li Dong, Yang Ge, Guang-Yu An
A 4-miRNA signature act as a novel prognostic biomarker in patients with Sarcoma
Xiaotao Chen, Lumei Cao, Ningning Xie, Xiaowei Xu, Ming Liu, Kai Wang
TGF-β signaling proteins and CYP24A1 may serve as surrogate markers for progesterone calcitriol treatment in ovarian and endometrial cancers of different histological types
Ana Paucarmayta, Hannah Taitz, Yovanni Casablanca, Gustavo C. Rodriguez, G. Larry Maxwell, Kathleen M. Darcy, Viqar Syed
A scoring model combining serum alpha-fetoprotein and tumor size and number predicts prognosis in hepatitis B virus-related hepatocellular carcinoma patients after curative hepatectomy
Bai Wei, Jing-San Chen, Sheng-Li Yang, George G. Chen, Hao He
Secondary particle production and physical properties during dose enhancement for spread-out Bragg peaks
Chulhwan Hwang, Jung Hoon Kim
Albumin-bilirubin grade as a prognostic factor of hepatocellular carcinoma after treatment with orthotopic liver transplantation
Jianhua Liao, Jingting Liu, Changcan Li, Junwei Fan, Zhaowen Wang
IL-10 promoter hypomethylation is associated with increased IL-10 expression and poor survival in hepatocellular carcinoma
Xianjing Zhang, Mingzhu Lu, Yun Xu, Guangzhao He, Qian Liu, Jing Zhu, Changsong Zhang, Xiaoli Zhang
Loss of CDH1 promotes the metastasis of hypopharyngeal squamous cell carcinoma through the STAT3-MMP-9 signaling pathway
Lan Mu, Xianfang Liu, Xiuxiu Liu, Na Sa, Shengli Zhou, Zhenghua Lv, Wei Xu
CD147 promotes glucose metabolism, invasion and metastasis via PI3K/AKT pathway in oral squamous cell carcinomas
Yi Huang, Jing Xu, Ying Xu, Li Li, Min Zheng
FAM46B suppresses proliferation, migration and invasion of non-small cell lung cancer via β-catenin/MMP7 signaling
Hongyang Sang, Song Wu, Xifang Chen, Shaofei Cheng, Qianping Li
Comparison of the effect on the prognosis of HCC in terms of different surgical approaches for hepatic inflow occlusion
Hong-Hao Li, Liang Ma, Bang-De Xiang, Lu-Nan Qi, Le-Qun Li
LINC00052 suppressed glioma cell proliferation and invasion by downregulating insulin-like growth factor 2
Yinzi Piao, Mingyang Li, Qian Zhang
Changes in immune markers in tumor-free lymph node and peripheral blood of malignant head and neck cancer patients
Soon-Hyun Ahn, Sung Joon Park, Hanaro Park, Joo Yeon Choi, Seong Dong Kim, Sungjun Han, Eun Jae Chung, Woo-Jin Jeong
Plasma cell-free DNA integrity: a potential biomarker to monitor the response of breast cancer to neoadjuvant chemotherapy
Wei Wang, Weijie Zhang, Lei Su, Jianfeng Sang, Shui Wang, Yongzhong Yao
Downregulated let-7d positively stimulates rectum adenocarcinoma cell malignant biological behaviors by upregulating ATP binding cassette subfamily C member 2
Zhen-Ji Liu, Yuan-Yuan Ma, Tong-Ming Liu, Jian-Xin Wang, Li Zhang, Lei Jin, Miao Yu, Hua-Long Yu
Hepatocellular carcinoma serum derived exosomal HIF-1α induces phosphoinositide-3 kinase/protein kinase B signaling to induce the angiogenesis and proliferation of HCC
Qingyu Xu, Ran You, Guowen Yin, Jianping Gu
Acid-induced autophagy protects human gastric cancer cells from apoptosis by activating Erk1/2 pathway
Yuan Gao, Weiwei Qi, Shihai Liu, Shufen Zhao, Jing Lv, Wensheng Qiu
Influences of information management path coordination with dynamic monitoring on the quality of hospital drug management
Xiuxin Guo, Jiwei Huang, Caiyun Jiang, Weifeng Zheng, Zhuying Liu
Effects of antisense lncRNA PCBP1-AS1 on biological behaviors of vulvar squamous carcinoma cells by regulating TRAF5 and NF-κB expression
Hongyu Wang, Ling Ouyang, Shan Gao
Fluid shear stress-induced IL-8/CXCR signaling in human ovarian cancer cells
Lei Sun, Jirui Wen, Ling Wang, Qiao Wen, Jiang Wu, Mingjiang Bie

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.


Original Article


Review Article


Case report


Brief Report


Letter to the Editor


Editorial Commentary