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TCR 2023 Annual Report

Greetings from the Editorial Office of TCR! More >>

Translational Cancer Research 2022 CiteScore Released: 1.2

We are pleased to announce that the Translational Cancer Research (TCR) has received its 2022 CiteScore: 1.2, ranking 232 out of 312 journals in the Radiology, Nuclear... More >>

New Impact Factor for Translational Cancer Research: 0.9

We are pleased to announce that Translational Cancer Research (TCR) has attained its latest impact factor update for the 2022 citation year: 0.9 (Figure 1). More >>

Original Article

Disulfidptosis and ferroptosis related genes predict prognosis and personalize treatment for hepatocellular carcinoma
Jin-Feng Liu, Lei Huang, Xiao-Ping Zhou, Chun-Rong Li, Miao-Feng Liu, Yi-Hua Liang, Qiu-Hai Yu, Jun-Rong Wu
Development and validation of a nomogram to predict overall survival of conjunctival melanoma: a population-based study
Yuan Peng, Lingmei Yuan, Shipeng Zou, Yanwei Li, Shengzhi Tong, Binglin Huang
A novel gene signature related to fatty acid metabolism predicts prognosis, immune landscape, and drug sensitivity in early-stage lung squamous cell carcinoma
Juqing Xu, Maoran Yu, Weifei Fan, Jifeng Feng
A nomogram for predicting overall survival of breast cancer with regional lymph node metastasis in young women
Ruiyi Sun, Ying Huang, Xinxin Chen, Haixia Jia
Development of a multiparametric model for predicting the response to neoadjuvant chemotherapy in breast cancer
Fusheng Qian, Yajing Mao, Jie Dong, Feiyue Xie, Xin Fang, Qian Zhang, Panpan Xia, Xinghua Han, Nannan Lu
Huaier granule improves liver inflammation and fibrosis and prevents recurrence in hepatitis B virus related hepatocellular carcinoma
Qionglan Wu, Jinhua Zeng, Jianxing Zeng, Yao Huang
Identification and verification of anoikis-related gene markers to predict the prognosis of patients with bladder cancer and assist in the diagnosis and treatment of bladder cancer
Hubo Li, Xinghua Bao, Yonggui Xiao, Hang Yin, Xiaoyan Han, Shaosan Kang
The diagnostic, prognostic, drug sensitivity and ceRNA internet of PPP4R1 in liver hepatocellular carcinoma (LIHC)
Xiaowei Li, Yinglian Pan, Siren Feng, Weimei Xing, Bo Lin, Wei Li, Mengsen Li, Mingyue Zhu
Preliminary exploration of the potential biological functions and prognosis values of RAB4B in pan-cancer combing with experimental validation in BLCA
Kezhen Li, Shengsheng Liang, Hua Mi
Function of homocysteine and HE4 in endometrial carcinoma: verified by prospective experiment
Zhaoxia Yang, Jianyun Zhou, Jiacong Wu, Guangquan Liu, Qinghua Xi
Study on the effect of different durations of decalcification and depigmentation on programmed death ligand 1 immunohistochemical staining
Chengmin Zhou, Jun Hou, Hao Dong, Yang Liu, Yehan Zhou
Analysis of the origin and invasion of prostate cancer from autopsy and radical prostatectomy specimens
Zhipeng Mai, Runqiang Yuan, Weigang Yan, Yi Zhou, Zhien Zhou, Miao Ren, Yu Xiao, Hongxing Huang, Yaqiang Huang
HES1 induces ITPR1-mediated autophagy to exert anti-metastatic effects in pituitary adenomas
Chunjian Qiu, Yao Yao, Suqin Hu, Yixin Xu
Multivariate logistic regression analysis of the clinical factors influencing locally advanced prostate cancer
Zongpan Ke, Yan Xu, Yawei Shu, Changming Wang, Baorui Wu, Bin Zhang, Ping Xiang, Xuechun Hu
The value of a panel of circulating microRNAs in screening prostate cancer
Chen Sun, Chong Lu, Xinji Li, Rongkang Li, Zhenyu Wen, Zhenjian Ge, Wenkang Chen, Yingqi Li, Suolei Sun, Qingshan Yang, Lingzhi Tao, Hang Li, Yongqing Lai
Development and validation of nomogram-based models for personalized survival assessment in pediatric hepatoblastoma patients
Weiming Chen, Ling Zhang, Bing Zhang, Yifan Fang, Yuanbin He
Comprehensive analysis of the effects of the cuprotosis-associated gene SLC31A1 on patient prognosis and tumor microenvironment in human cancer
Guiqian Zhang, Ning Wang, Shixun Ma, Pengxian Tao, Hui Cai
Bibliometric and visual analysis of photodynamic therapy for lung cancer from 2010 to 2022
Zhirong Gu, Liu Wu, Jinxing Li, Bo Liu, Min Huang, Silin Zheng
A challenging surgical technique: single-port endoscopic-assisted radical mastectomy in retrograde way and immediate reconstruction using prosthesis implantation
Yongqiang Chen, Jianhua Xu, Shanyan Hong, Shuangta Xu
Disease prognosis and therapeutic strategies in patients with advanced non-small cell lung cancer (NSCLC): a 6-year epidemiological study between 2015–2021
Saad Alamri, Maryam Zaki Badah, Soha Zorgi, Reva Alenazi, Huda M. Alshanbari, Mohamed A. M. Ali, Ghida Murished, Maaweya E. Awadalla, Ammar Alshihre, Waleed A. Alghareeb, Bandar Alosaimi
A centrosome-related gene signature for predicting the overall survival of uveal melanoma
Xin Yu, Xiaoyu Guo, Wenge Li, Juanjuan Li
Identification and validation of mitophagy-related signatures as a novel prognostic model for colorectal cancer
Qing Ke, Yun Wang, Yanyan Deng, Jinjin Wang, Mengjiao Yuan, Aifeng Liang, Jin Wang, Qian Gong
Overexpression of KLHL22 correlates with poor prognosis in patients with triple-negative breast cancer
Tianzhi Zhang, Jiani Liu, Jin Wang, Chao Zhang
A real-world evaluation of tislelizumab in patients with head and neck cancer
Baomin Zheng, Zhou Huang, Weixin Liu, Dan Zhao, Xiaolong Xu, Shaowen Xiao, Yan Sun, Weihu Wang
Multiomics combined with single-cell analysis shows that mitophagy-related genes could accurately predict the prognosis of patients with clear cell renal cell carcinoma
Hang Yin, Yonggui Xiao, Hubo Li, Yong Wang, Liguo Zhang, Anliang Yao, Shaosan Kang, Fenghong Cao
B7-H3 promotes proliferation and migration of lung cancer cells by modulating PI3K/AKT pathway via ENO1 activity
Xianan Wu, Congcong Ding, Yingqi Liu, Ke Dong, Huizhong Zhang
Upregulation of RACGAP1 is correlated with poor prognosis and immune infiltration in hepatocellular carcinoma
Yangyang Zhou, Shimeng Zheng, Qihang Guo, Ning Wei, Zhuanglong Xiao, Yuhu Song
Construction and validation of a novel web-based nomogram for primary ocular adnexal lymphoma: a real-world analysis based on the Surveillance, Epidemiology, and End Results database
Zhen Chen, Ling Ye, Xia Li
Bilateral Wilms tumor: 10-year experience from a single center in China
Wei Yao, Shuting Weng, Kai Li, Jian Shen, Rui Dong, Kuiran Dong
Comparable prognosis of early gastric cancer between intestinal type and diffuse type in patients of age 75 and older: a SEER-based cohort study
Ping Yin, Rencheng Cai, Xiaohua Zhou, Xuemin Yao, Qiufen Yang, Yuehong Jin, Xuehua Jiao, Chengjie Lu, Zhenguo Qiao
Non-targeted metabolomics analysis of indoleamine 2,3-dioxygenase inhibitor treatment in a mouse model of early-stage lung adenocarcinoma
Meixiang Xu, Jiayang Chen, Chaoyang Peng, Liang Mo
A prognostic nomogram based on least absolute shrinkage and selection operator Cox regression in patients with pulmonary large-cell neuroendocrine carcinoma
Tianming Zhang, Zhiqing Mao, Minghui Ma, Guangyan Li, Xiaozhong Qiao, Hong Wang
An exploratory study of whether axillary lymph node dissection can be avoided in breast cancer patients with positive lymph nodes
Fei Ren, Chenxuan Yang, Jiaxiang Liu, Kexin Feng, Qingyao Shang, Xiyu Kang, Ruixuan Zhang, Li Li, Shuangtao Zhao, Xin Wang, Xiang Wang
WTAP-mediated abnormal m6A modification promotes cancer progression by remodeling the tumor microenvironment: bibliometric and database analyses
Yumeng Du, Lihua Huang, Mao Long, Xin Wu, Jinglei Miao
The integration of bulk and single-cell sequencing data revealed the function of FKBP10 in the gastric cancer microenvironment
Manling Xie, Liang Liang, Liuying Yu, Jiping Shi, Yu Lei, Jun Huang, Xiaoyong Cai
Endoscopic resection vs. endoscopic resection plus chemoradiation for T1 stage colorectal cancer: a real-world retrospective cohort study
Han Chen, Die Hu, Wei Su, Shuo Li, Guoxin Zhang, Xinmin Si, Xiaoying Zhou
CXCL family-related classification predicts prognosis and response to immunotherapy in patients with head and neck squamous cell carcinoma based on TCGA and GEO databases
Shun Gao, Xuemei Tang, Chao Gao, Xinrui Gao, Xuanzhu Guo, Yuyao Luo, Sijie Li, Guotao Gong, Yan Zhang, Sheng Lin
Construction of a diagnostic nomogram model for predicting the risk of lymph node metastasis in clinical T1 or T2 colon cancer based on the SEER database
Weichao Zeng, Jianhua Xu, Zhengrong Liao, Yafeng Sun
NF2 is a candidate diagnosis, prognostic, and immunotherapeutic biomarker: a systematic pan-cancer analysis
Honglu Zhang, Jiyong Liu
Detection of thyroglobulin for diagnosis of metastatic lateral cervical lymph nodes in papillary thyroid carcinoma: accuracy and application in clinical practice
Baolin Chen, Zhongliang Yan, Yuxiang Bao, Jiayang Li, Chengmin Luo, Guangxu Yang, Taolang Li, Xiaoming Cheng, Junyuan Lv
Construction of an exosome-associated miRNA-mRNA regulatory network and validation of FYCO1 and miR-17-5p as potential biomarkers associated with ovarian cancer
Li Chen, Linglin Lai, Lingbo Zheng, Youzhi Wang, Huiqin Lu, Yan Chen
Construction and validation of a joint diagnosis model based on random forest and artificial intelligence network for hepatitis B-related hepatocellular carcinoma
Xili Jiang, Jiyun Hu, Shucai Xie
A postoperative tumor-specific death prediction model for patients with endometrial cancer: a retrospective study
Hailong Chen, Weiwei Yan, Dechang Xu, Qi Wang, Ying Yu, Jing Huang, Qian Zhou, Wei Xiao, David Lukanovic, Fabio Barra, Alberto Izzotti, Feizhou Jiang
A comprehensive analysis of the prognostic and immunological role of ANK3 in pan-cancer
Yunfei Tan, Wei Meng, Zhaosheng Jiang, Ningning Li, Tong Zhang, Jiayi Zhang, Limin Ma, Yangbo Guan
Significance of saline nasalirrigation for COVID-19 infection: observations and reflections from nursing care of nasopharyngeal carcinoma
Linghui Yan, Jianming Ding, Mengting Xu, Xiaoting Lin, Michael Benedict A. Mejia, Jiawei Chen, Yiying Xu, Huiling Hong, Lisha Chen

Brief Report

The impact of alpha-1 antitrypsin deficiency alleles on lung cancer survival
José María Hernández-Pérez, Carolina Ramos-Izquierdo, Juan Marco Figueira-Gonçalves, Francisco Martínez-Bugallo, Yolanda Ramallo-Fariña, Lorenzo Pérez-Negrín

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Magnetic resonance imaging of pancreatic malignancy
Mellena D. Bridges
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Advances on immunotherapy in breast cancer
Kanthi Athreya, Sonia Ali
Targeting the folate receptor for the treatment of ovarian cancer
Robert J. Lutz
Computational resources for radiomics
Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
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Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
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Normal tissue protection for improving radiotherapy: where are the Gaps?
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Original Articles

Third generation gold nanoplatform optimized for radiation therapy
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Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.