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Implementation of transparent peer review at Translational Cancer Research

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a... More >>

TCR Annual Report (2019)

Greetings from Editor-in-Chief and Editorial Office of Translational Cancer Research! More >>

Application of the CARE Guideline as reporting standard in Translational Cancer Research

Translational Cancer Research welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to... More >>

Meet the Professor more

Theresa L. Whiteside: if you believe you are correct, stay with it even if no one initially... More >>
Maria G. Castro: science is a highly collaborative endeavor that transcends different barriers! More >>
Louis Dubeau: putting aside biases and validating accustomed dogmas make successful scientists More >>

Original Article

Pancreatic cancer differential methylation atlas in blood, peri-carcinomatous and diseased tissue
Huan Wang, Fan Yin, Fang Yuan, Yuehua Men, Muhong Deng, Yang Liu, Qingfang Li
Prognosis and clinicopathological characteristics of renal cell carcinoma: does bilateral occurrence influence overall and cancer-specific survival?
Tao Jiang, Yu-Peng Wu, Shao-Hao Chen, Zhi-Bin Ke, Ying-Chun Liang, Ning Xu
The prognostic significance of neutrophil-to-lymphocyte ratio at different time points in patients with hepatocellular carcinoma receiving liver resection
Tianxing Dai, Guozhen Lin, Mingbin Deng, Shuguang Zhu, Haibo Li, Jia Yao, Hua Li, Wei Liu, Yang Yang, Guihua Chen, Guoying Wang
Dose accumulation in IMRT for left breast cancer determined by applying deformation registration
Ming Su, Guanzhong Gong, Xiaoping Qiu, Yong Yin
Clinical significance of PI3 and HLA-DOB as potential prognostic predicators for ovarian cancer
Yanrong Li, Haixia Li, Baojun Yang, Jing Wei, Cheng Zhen, Limin Feng
Identification of key candidate genes and pathways in follicular variant papillary thyroid carcinoma by integrated bioinformatical analysis
Lanyu Jing, Fada Xia, Xin Du, Bo Jiang, Yong Chen, Xinying Li
Effect of prone and supine treatment positions for postoperative treatment of rectal cancer on target dose coverage and small bowel sparing using intensity-modulated radiation therapy
Yongqiang Yang, Shang Cai, Tianshu Zhao, Qiliang Peng, Jianjun Qian, Ye Tian
Necroptosis of osteoblasts was induced by breast cancer cells in vitro
Xiang Ji, Ruideng Wang, Hai Tang, Hao Chen, Li Bao, Fei Feng, Pu Jia
The prognosis analysis of RFWD2 inhibiting the expression of ETV1 in colorectal cancer
Wei Huang, Xiumei Tian, Xiaoying Guan
T stage prediction of colorectal tumor based on multiparametric functional images
Yafang Dou, Xuefeng Tang, Yingying Liu, Zhigang Gong
Long-term survival results of patients with locally advanced gastric cancer and pathological complete response after neoadjuvant chemotherapy and resection
Tongbo Wang, Nianchang Wang, Hong Zhou, Aiping Zhou, Jing Jin, Yingtai Chen, Dongbing Zhao
The clinicopathological study of lung cancer concealed in end-stage of interstitial lung disease
Bei Wang, Xiaoyan Zhang, Huang Chen, Lei Yang, Jie Li, Fei Xiao, Chaoyang Liang, Dingrong Zhong
Systematic review and meta-analysis of the clinical survival significance of Sialyl-Tn expression in histological tissues from cancer patients
Roberto Lugo, Azalia Ávila-Nava, Rodrigo García-Pérez, Sarahí Herrera-Escalante, Jocelyne De la Cruz-Acosta, Ana Ligia Gutiérrez-Solis
Plumbagin inhibits tumor angiogenesis of gastric carcinoma in mice by modulating nuclear factor-kappa B pathway
Chengqian Yang, Xingbo Feng, Zengxian Li, Qingsi He
Proteomic and ultrastructural analysis of Clara cell and type II alveolar epithelial cell-type lung cancer cells
Wen-Li Hou, Ming Chang, Xiao-Feng Liu, Lin-Sen Hu, Shu-Cheng Hua
Benchmarking of electron beam parameters based on Monte Carlo linear accelerator simulation
Fan Zhang, Mi Zhou, Jing Liu, Lu Yue, Lihua Deng, Zhijian Xu, Gang Wang
Thymidylate synthase (TS) immunostaining in the diagnosis of the myoepithelial cells, basal cells, stratified epithelium cells, and associated tumors
Rui Guo, Yi Tian, Na Zhang, Hong Huang, Ying Huang, Xueyuan Jin, Xiaozhong Huang, Zongfang Li, Jun Yang
Widowed status predicts poor overall survival of Chinese patients with prostate cancer
Si-Huai Huang, Yi-Ning Li, Jian-Wei Li, Yi-Hong Guo, Xue-Feng Su
SRC-1 and Twist1 are prognostic indicators of liver cancer and are associated with cell viability, invasion, migration and epithelial-mesenchymal transformation of hepatocellular carcinoma cells
Peng-Wei Zhao, Jia-Wei Zhang, Yan Liu, Yan Liu, Jiang-Wei Liu, Jian-Zhao Huang
Clinical features and prognosis analysis of 57 patients with primary tracheal tumors
Mao Jiang, Qunjuan Lei, Xin Lv, Lijun Zou, Jingjing Liu, Jie Meng
Survival analyses and immunohistochemical study of primary signet ring cell carcinoma of the lung adenocarcinoma
Chunji Chen, Lei Wang, Chang Gu, Yiyang Wang, Xufeng Pan, Shijie Fu, Jun Yang, Rui Wang
Exploring and validating the clinical risk factors for pancreatic cancer in chronic pancreatitis patients using electronic medical records datasets: three cohorts comprising 2,960 patients
Xin Zhao, Ren Lang, Zhigang Zhang, Weiling Zhao, Zhiwei Ji, Hua Tan, Xiaobo Zhou
Liver kinase B1 correlates with prognosis and epithelial-mesenchymal transition of resectable early stage non-small cell lung cancer
Zhaohui Qin, Ruilin Xie, Wei Zhang, Minghui Wan, Longzheng Zhang, Hui Wang, Na Li, Qingwei Qin, Yuanhu Yao
Prolactin (PRL), placenta growth factor (PIGF) and nerve growth factor receptor (NGFR) as biomarkers for early diagnosis and prognosis in patients with esophageal squamous cell carcinoma (ESCC)
Xiaohong Ai, Xiaoxi Zhu, Jianhong Zuo
Cyclin-dependent kinase 4/6 inhibitor in combination with endocrine therapy versus endocrine therapy only for advanced breast cancer: a systematic review and meta-analysis
Zhi-Hong Xu, Heng Zhang, Deng-Hui Wei, Li-Li Xie, Chun-Sen Xu
Construction of dysregulated long non-coding RNA-associated competing endogenous RNA network in uterine corpus endometrial carcinoma
Na Li, Peng Mi, Yuanjing Hu
Polymorphisms of TLR9 gene are associated with a decreased risk of H. pylori infection in a Chinese population
Fang Gao, Jindong Qin, Xingru Wei, Xuyang Tian, Wenjie Dong, Tong Dang, Yanbin Jia
The expression of apolipoproteina1 and its correlation with infiltration of urologic neoplasm
Huihui Hu, Bei Gong, Man Zhang
Copy number variations of MMP-9 are prognostic biomarkers for hepatocellular carcinoma
Xi Yu, Jing Huang, Shengdong Wu, Yi Huang, Yuying Shan, Caide Lu
microRNA-324 plays an oncogenic role in bladder cancer cell growth and motility
Kuo-Wang Tsai, Wei-Ting Kuo, Shaw-Yeu Jeng
CENPE promotes glioblastomas proliferation by directly binding to WEE1
Chuanling Ma, Jianchao Wang, Jie Zhou, Kaisen Liao, Min Yang, Fangqiong Li, Meng Zhang
Correlations of AKIP1, CXCL1 and CXCL2 expressions with clinicopathological features and survival profiles in cervical cancer patients
Xiaoyan Wan, Zubei Hong, Yuhong Mao, Wen Di
Measuring serum human epididymis secretory protein autoantibody as an early biomarker of lung cancer
Bin Yang, Na Ren, Bo Guo, Hua Xin, Yiyu Yin
Effect of curcumin-lipiodol emulsion combined with absorbable anti-adhesion film through double embolic pathway on angiogenesis and overall survival (OS) time of VX2 liver cancer rabbits
Chuanyu Yang, Zheng Xu, Kai Nie, Jing Liu
Inhibition of osteopontin overcomes acquired resistance to afatinib in EGFR-mutant non-small-cell lung cancer
Hongye Zhang, Ruiyu Wang, Mingxia Wang, Judong Luo, Changmin Liu
High-mobility group A1 (HMGA1) gene expressions in various colorectal cancer cell lines and correlation with prognosis
Maruthi Prasad E., Ting Liu, Xiang Zhang, Hongli Yang, Jing Wang, Renpeng Huang, Yuhong Wang
Reduction of Hip2 suppresses gastric cancer cell proliferation, migration, invasion and tumorigenesis
Jugang Wu, Baoxing Tian, Jianjun Yang, Haizhong Huo, Zhicheng Song, Jiwei Yu, Yan Gu
Matrine reverses the drug resistance of K562/ADM cells to ADM and VCR via promoting autophagy
Zhao Li, Ning Wang, Ting Yue, Lu Liu
A comparative study of osteopontin expression, Ki67 index and prognosis in squamous cell carcinoma and cysts of the oral cavity
Marta Woźniak, Marek Nahajowski, Sylwia Hnitecka, Monika Rutkowska, Grzegorz Marek, Anil Agrawal, Sebastian Makuch, Siddarth Agrawal, Piotr Ziółkowski
The lncRNAs MIR600HG and TSPOAP1-AS1 may potentially act as biomarkers for predicting pancreatic cancer
Jing Tian, Yuanliang Wang
Comparison of treatment strategies for patients with limited-stage small cell lung cancer who received chemotherapy
Shenhai Wei, Bo Wei, Jintao Tian, Xiaoping Song, Bingqun Wu, Pengcheng Hu
Chidamide inhibits t(8;21) AML cell proliferation and AMK1/ETO and C-KIT expression by inhibiting ERK1/2 signaling pathway
Jing Liu, Na Lv, Lei Zhou, Yan Li, Li Yu
C-X-C motif chemokine receptor type 2 correlates with higher disease stages and predicts worse prognosis, and its downregulation enhances chemotherapy sensitivity in triple-negative breast cancer
Huimin Chu, Wenhuan Li, Hai Li
Association of CMYC polymorphisms with hepatoblastoma risk
Tianyou Yang, Yang Wen, Jiahao Li, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Yuxiao Yao, Jiao Zhang, Suhong Li, Huimin Xia, Jing He, Yan Zou
Screening key miRNAs and genes in prostate cancer by microarray analysis
Jianhui Wu, Xuemei Li, Fei Luo, Jun Yan, Kuo Yang
The analysis of a ceRNA network and the correlation between lncRNA, miRNA, and mRNA in bladder cancer
Ranran Dai, You Zhou, Zhishan Chen, Zihao Zou, Ping Liu, Xingcheng Gao
Clinical features and prognosis of primary tracheal small cell carcinoma: a population-based analysis
Kun Chen, Zhihao Yang, Xinbo Zhang, Tianhao Zhao, Xiang Zhang, Wenfeng Li, Shanshan Yu, Deyao Xie, Zhifeng He, Dezhi Cheng
Overexpression of lncRNA H19 leads to reduced proliferation in TSCC cells through miR-675-5p/GPR55
Zhengguo Piao, Rui Zou, Ying Lin, Zhiqiang Li, Zhibao Bai, Libin Zhou, Lihong Wu, Kexiong Ouyang
Three therapeutic regimens based on induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: a single center experience
Lin Jiang, Liang Guo, Kejing Wang, Shengye Wang, Meiyu Fang, Jianlin Lou
Modified subcutaneous suction drainage to prevent incisional surgical site infections after radical colorectal surgery
Jinfu Zhuang, Wei Zheng, Shugang Yang, Jianxin Ye
Brucea javanica oil emulsion suppresses tumor growth in human cervical cancer cells through inhibition of the E6 oncogene and induction of apoptosis
Ling Ye, Jian-Fu Zhao, Yi-Ming Wang, Wen-Hui Chen, Shen Qian, Zhong-Guo Zhou, Meng Xu
Autologous ilium graft combination with Y-shaped titanium plate fixation for chest wall reconstruction after resection of primary sternal tumors—a clinical study from three institutions
Shuonan Xu, Yawei Dou, Guolong Zhao, Jianfei Zhu, Wei Tian, Wei Sun, Zongzhi Liu, Lanjun Zhang, Hongtao Wang
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction
Yang Wang, Heng-Xing Liang, Chun-Min Zhang, Min Zou, Bi-Bo Zou, Wei Wei, Wen Hu
A comparison study of post-operative infection analysis of cold-knife conization and loop electrosurgical excision procedure for cervical high-grade squamous intraepithelial lesion
Liangzhi Cai, Yunmei Huang, Chaoqin Lin, Guifeng Liu, Xiaodan Mao, Binghua Dong, Ting Lu, Pengming Sun
LncRNA MEG3 inhibits the development of nasopharyngeal carcinoma by sponging miR-543 targeting KLF4
Jiayu Ning, Liqin Zhang, Hua Guo, Sujuan Zhou, Xiaomei Sun, Weijing Bao
Treatment and prognosis for patients with differentiated thyroid carcinoma bone metastases
Shiqi Wang, Juanzhang Luo, Zhaoming Zhong, Xiao Qi, Ting Liu, Rujia Qin, Zaili Zhao, Yan Xi, Ruimei Sun, Yaohong Wu, Chuanzheng Sun
High expression of TOP2A gene predicted poor prognosis of hepatocellular carcinoma after radical hepatectomy
Hongyu Cai, Xinhua Zhu, Fei Qian, Bingfeng Shao, Yuan Zhou, Yixin Zhang, Zhong Chen
Chemotherapy for breast cancer progresses to liver metastases after surgery and systemic treatment
Tao Yin, Lei Nie, Dongde Wu, Baozhen Liu, Yaojun Feng, Xinhong Wu, Chenggang Luo, Jianjun Liang
Synergistic effects of bevacizumab in combination with β-elemene on subcutaneous xenografts derived from HCT-116 human colon cancer cells
Jin-Na Li, Feng Xie, Ying Wang
Long noncoding RNA UCA1 facilitates cell proliferation and inhibits apoptosis in retinoblastoma by activating the PI3K/Akt pathway
Zhongfang Yuan, Zhaona Li
The clinical analysis of pulmonary lymphoepithelioma-like carcinoma with epithelioid granuloma
Guoying Gao, Chengzhi Zhou, Guofeng Wu, Weijie Guan, Guosheng Deng, Zheng Zhu, Xinqing Lin, Xiaohong Xie, Zhanhong Xie, Jiexia Zhang, Ming Ouyang, Nanshan Zhong, Shiyue Li, Yinyin Qin
Ethanol extract of Acanthopanax senticosus (Rupr. & Maxim.) Harms induces liver cancer cell apoptosis through inhibiting NF-κB
Baolei Zhao, Wentao Zhu, Xinqiang Han, Xin Li, Yanmin Lu, Xuefeng Cao, Fan Zhang, Xutao Lin, Xingyuan Zhang, Qiangpu Chen
A positive feedback loop formed by NGFR and FOXP3 contributes to the resistance of non-small cell lung cancer to icotinib
Jun Huang, Qiuhua Yu, Yanjuan Zhou, Ying Chu, Feng Jiang, Xiaobo Zhu, Junjie Zhang, Qiang Wang
CXCL8 is a potential biomarker for predicting disease progression in gastric carcinoma
Wen-Qian Qi, Qian Zhang, Jiang-Bin Wang
Ectopic expression of CNN2 of colon cancer promotes cell migration
Lei Zheng, Peng Zhao, Kai Liu, Da-Lu Kong
Integrative analysis of mRNA, miRNA and lncRNA profiles reveals the commonness between bladder cancer and breast cancer
Wenbin Xu, Lin Hua, Hong Xia
Effects of different CT value assignment methods on dose calculations in radiotherapy planning for brain metastases
Jianxin Ren, Guanzhong Gong, Xingmin Ma, Xinsen Yao, Yong Yin
MicorRNA-148b inhibits cell proliferation and facilitates cell apoptosis by regulating DNA Methyltransferase 1 in endometrial cancer
Ruxin Chen, Xiaochen Ma, Li Zhang
Clinicopathological features and prognosis of patients with esophageal cancer as the second primary cancer: a large population-based analysis using the SEER program [2000–2015]
Zhencong Chen, Ming Li, Ke Ma, Zhengyang Hu, Shuai Wang, Hongyu Chen, Yuansheng Zheng, Cheng Zhan, Zongwu Lin, Qun Wang
The role of lncRNA LSAT1 in the invasion and metastasis of non-small cell lung cancer under hypoxia
Lei Zhang, Zhi-Yong Wan, Xiang Zhang, Jun Liu, Wei-Yi Huang, Yu-Bing Zhao
The suppressing effects of VEGF-mediated angiogenesis at different administration sequences of apatinib and transarterial embolization in vivo
Nan Li, Yong-Hui Huang
Expression of neuro-oncological ventral antigen-1 in small-cell lung cancer and its value in pathological diagnosis
Shuangshuang Deng, Meixuan Liu, Tianyu Xiao, Jinli Gao
Impact of interstitial lung disease on postoperative morbidity and 90-day mortality after pulmonary resection
Weipeng Shao, Jingjing Huang, Hongxiang Feng, Hongliang Sun, Yanhong Ren, Xiaowei Wang, Zhenrong Zhang, Deruo Liu
Clinical features and prognostic factors in 190 cancer patients with brain metastases
Min-Hang Zhou, Yuan Wu, Jun-Zhong Sun
HSP70 regulates cell proliferation and apoptosis in actinomycin-D-treated lung cancer cells
Kai Zhang, Ruonan Zhai, Teng Xue, Xiaoyan Xu, Yanan Ren, Mingze Ma, Fengxian Shi, Hang Wang, Na Wang, Fang Zhou
DAB2 suppresses gastric cancer migration by regulating the Wnt/β-catenin and Hippo-YAP signaling pathways
Hua Wang, Surong Dong, Yun Liu, Feng Ma, Jian Fang, Wentao Zhang, Shihe Shao, Hongxing Shen, Jingpeng Jin
Expression of CYB5D2 expression is associated with epithelial-mesenchymal transition and survival rates in patients with cervical cancer
Dongxue Li, Bing Qiu, Xiaohang Chen, Liang Hu, Lijuan Wen, Fengxiang Wei
Triptonide inhibits metastasis potential of thyroid cancer cells via astrocyte elevated gene-1
Liangjie Fu, Xiaohong Niu, Ruhui Jin, Feiyun Xu, Jiguo Ding, Li Zhang, Zihui Huang
Tailoring neoadjuvant chemotherapy for patients with breast cancer who have achieved pathologic complete response
Xianjun Li, Yang Liu, Ming Shan, Bingqi Xu, Yubo Lu, Guoqiang Zhang
Clinicopathological significance and prognostic implication of CD44 and its splice variants (v3 and v6) in colorectal cancer
Bing Yan, Ying Mu, Meiqi Cui, Long Liu
Local treatment for liver oligometastases in breast cancer patients: identification of prognostic factors and exploration of appropriate treatment strategy
Kuikui Jiang, Wen Xia, Ruoxi Hong, Fei Xu, Qiufan Zheng, Qianyi Lu, Kaping Lee, Yuan Li, Qinglian Zhai, Yanxia Shi, Zhongyu Yuan, Shusen Wang
5-aza-2’-deoxycytidine (DAC) treatment induces the MAGE-A10 expression and improves the cytotoxicity of MAGE-A10-specific CTLs in lung cancer cells
Zhenhua Li, Peng Guo, Peiyuan Guo, Keqin Dong, Fei Liu, Yunyan Wu, Juan Li, Baoen Shan, Meixiang Sang

Review Article

An update on Wnt signaling pathway in cancer
Yanlu Zhang, Dan Zu, Zhe Chen, Guoqing Ying
Adrenocortical carcinoma: a literature review
Ammu Thampi, Ekta Shah, Ghada Elshimy, Ricardo Correa
Applications of hyperspectral imaging in the detection and diagnosis of solid tumors
Yating Zhang, Xiaoqian Wu, Li He, Chan Meng, Shunda Du, Jie Bao, Yongchang Zheng

Case Report

Liver metastasis and local recurrence of meningeal hemangiopericytoma: a case report
Aimaiti Yasen, Bo Ran, Tiemin Jiang, Yusufukadier Maimaitinijiati, Ruiqing Zhang, Qiang Guo, Yingmei Shao, Tuerganaili Aji, Hao Wen
Air in the biliary duct as an indicator of Type V Mirizzi syndrome: a case report
Jun-Wei Zhang, Feng Tian, Bing-Qi Li, Yi-Zhi Wang, Jun-Chao Guo
Decitabine as a treatment choice for de novo acute basophilic leukemia: transient response-a case report
Lei Cao, Rong Wang, Yan Wang, Si-Shu Zhao, Hui Yang, Ji Xu, Qi-Qiang Long, Guang-Sheng He, Jian-Yong Li

Research Highlights

MiR-596 down regulates SOX4 expression and is a potential novel biomarker for gastric cancer
Yongyi Chen, Wangang Gong, Wumin Dai, Zhiwen Pan, Xiaohong Xu, Huifen Jiang

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Magnetic resonance imaging of pancreatic malignancy
Mellena D. Bridges
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Advances on immunotherapy in breast cancer
Kanthi Athreya, Sonia Ali
Targeting the folate receptor for the treatment of ovarian cancer
Robert J. Lutz
Computational resources for radiomics
Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang


Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu


Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer


Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin


Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report

Original Article

Review Article

Research Highlight

Brief Report