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Original Article

Potential predictive value of JAK2 expression for Pan-cancer response to PD-1 blockade immunotherapy
Jie Peng, Lu-Shan Xiao, Zhong-Yi Dong, Wen-Wen Li, Kun-Yuan Wang, De-Hua Wu, Li Liu
Cyclin-dependent kinase 7 (CDK7) expression in human hepatocellular carcinoma: association with HCC progression, prognosis and cell proliferative capacity
Zheran Liu, Dajiao Liu, Rongrong Zhong, Qiuyun Su, Tiancheng Zhao, Fen Fu, Jinsheng Liu, Derong Xu, Changqing Zeng
Prognostic factors for unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolisation combined with radiotherapy
Zhonghua Qi, Qianqian Zhao, Renben Wang
The efficacy and tolerance of high pressure oxygen combined with chemotherapy in postoperative patients with advanced gastric cancer
Changlin Qian, Hua Liu, Jie Zhang, Zhiyong Shen
Methylation of O6-methylguanine DNA methyltransferase promoter is a predictive biomarker in Chinese melanoma patients treated with alkylating agents
Jiayi Yu, Huan Yu, Junya Yan, Xiaowen Wu, Lu Yang, Jie Dai, Meng Ma, Huan Tang, Tianxiao Xu, Zhihong Chi, Lu Si, Xinan Sheng, Chuangliang Cui, Jun Guo, Yan Kong
Prognostic value of tumor length in predicting survival for patients with esophageal cancer
Haijing Wang, Liangwen Bi, Lizhen Zhang, Weiyong Zhao, Min Yang, Xinchen Sun
Dosimetric predictors of acute hematologic toxicity due to intensity-modulated pelvic radiotherapy with concurrent chemotherapy for pelvic cancer patients
Yongqiang Yang, Wenjing Li, Jianjun Qian, Junjun Zhang, Yuntian Shen, Ye Tian
Prevalence and prognostic impact of synchronous distant metastases in patients with oral tongue squamous cell carcinoma: a SEER-based study
Yujiao Li, Xiaomin Ou, Chaosu Hu
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Hypertension and risk of cholangiocarcinoma: a systematic review and meta-analysis
Jianping Xiong, Weiyu Xu, Hanchun Huang, Jin Bian, Jianzhen Lin, Junyu Long, Yi Bai, Yiyao Xu, Tianyi Chi, Xin Lu, Haitao Zhao
Prognostic significance of the platelet-to-lymphocyte ratio in ovarian cancer: a meta-analysis
Weiyu Xu, Wenqin Wang, Min Yang, Lina Song, Jianping Xiong, Jianzhen Lin, Junyu Long, Yi Bai, Yongchang Zheng, Lin Zhao, Xinting Sang, Haitao Zhao
The expression and prognostic value of hypoxia-inducible factor- 1α and p53 in non-small cell lung carcinoma
Yuming Wan, Feng Li, Yali Shen, Huijiao Chen, Yachao Zhai, Jing Huang, Jin Wang, Feng Xu
Galectin-9 as a prognostic biomarker in small cell lung cancer
Yaolin Xu, Chao Guan, Xiaoye Zhang
Antineoplastic effects of Endostar combined with combretastatin A4 phosphate in vitro
Xianhua Fu, Yin Duan, Hongdan Shen, Yong Zou, Chi Pan, Demin Lu, Jianjin Huang, Jun Li, Suzhan Zhang
Methylated septin 9 gene for noninvasive diagnosis and therapy monitoring of breast cancer
Shen Chen, Changxin Zhou, Wei Liu, Shanping Sun, Anqi Zhang, Wenqiang Tang, Shan Zhang, Yang Zhang, Bo Fu
Efficacy, safety and prognostic factors analysis of first-line icotinib treatment in advanced non-small cell lung cancer patients with mutated EGFR
Aimi Huang, Qing Shen, Xiaolu Yu, Huimin Wang, Chunlei Shi, Baohui Han, Aiqin Gu
Prognostic significance of CD47 in human malignancies: a systematic review and meta-analysis
Hui-Jun Zhao, Fei Pa, Yi-Chao Shi, Xi Luo, Rong-Rong Ren, Li-Hua Peng, Yun-Sheng Yang
Diagnostic and prognostic value of KRAS mutations in circulating pancreatic ductal adenocarcinoma tumor DNA
Xiaowei Yang, Wei Xu, Xiuyun Tian, Jianhui Wu, Ang Lv, Chengpeng Li, Xiaoya Guan, Honggang Qian, Chunyi Hao
Combined computed tomography-measured tumor density and RECIST for evaluating neoadjuvant therapy in locally advanced gastrointestinal stromal tumors
Wei-Chih Su, Hsiang-Lin Tsai, Yung-Sung Yeh, Ching-Wen Huang, Cheng-Jen Ma, Chau-Yun Chen, Tsung-Kun Chang, Jaw-Yuan Wang
It is feasible to perform laparoscopic pancreaticoduodenectomy for patients with prior abdominal operation
Yunqiang Cai, Junfeng Wang, Xin Wang, Yongbin Li, Pan Gao, Bing Peng
Identification of novel genes and pathways in colorectal cancer exosomes: a bioinformatics study
Qiuxiang Huang, Ziyang Shen, Rujin Zang, Xiaoyan Fan, Li Yang, Mei Xue
Clinical implication of platelet-lymphocyte ratio and PD-L1 in breast cancer patients
Qianyi Lu, Tao Qin, Fei Xu, Yinduo Zeng, Wen Xia, Qiufan Zheng, Kaping Lee, Kai Zhang, Ge Qin, Man Tek Kong, Ruoxi Hong, Yanxia Shi, Zhongyu Yuan, Shusen Wang
Surgical stress biomarkers as early predictors of postoperative infectious complications in patients with colorectal cancer
Jing-Jing Liu, Ming-Shi Yang, Chao-Qun Cen, Chun Xu, Hong Yuan
Clinical outcomes with first-line chemotherapy versus endocrine therapy for adjuvant endocrine therapy-resistant metastatic breast cancer
Bin Shao, Yanlian Yang, Jinrong Qu, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Xiaoran Liu, Jing Wang, Weiyao Kong
Efficient cancer gene therapy with a Del1 fragment administered by hypodermic injection in a mouse explanted tumor model
Hisataka Kitano, Tomomi Ishikawa, Eri Tamura, Shinichiro Kokubun, Chiaki Hidai
Clinicopathologic features and prognostic factors of diffuse sclerosing variant of papillary thyroid carcinoma: a populationbased analysis
Yunjun Wang, Qing Guan, Jun Xiang, Duanshu Li
Risk stratification for prostate cancer via the integration of omics data of The Cancer Genome Atlas
Lin Hua, Hong Xia, Wenbin Xu, Ping Zhou
Diagnosis and treatment of primary hepatic lymphoma
Huayu Yang, Ziyi Yang, Xinting Sang, Yilei Mao, Xin Lu, Shouxian Zhong, Haifeng Xu
Clinical features and prognostic factors of cryptogenic hepatocellular carcinoma
Qichen Chen, Hong Zhao, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Jianqiang Cai

Brief Report

Ambient mass spectrometry-based detection system for tumor cells in human blood
Kaname Sakamoto, Yuichiro Fujita, Kazuaki Chikamatsu, Shota Tanaka, Sen Takeda, Keisuke Masuyama, Kentaro Yoshimura, Hiroki Ishii

Review Article

Mechanisms of resistance to chemotherapy and radiotherapy in hepatocellular carcinoma
Jiapei Guo, Leilei Li, Bin Guo, Dianxing Liu, Jun Shi, Chuntao Wu, Junmao Chen, Xiaowei Zhang, Jinghua Wu
Potential and importance of metalloproteinases and interleukins in inflammation and metastasization in non-small cell lung cancer
João Luís Pereira, Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, Christian Rolfo, António Araújo
Epigenetic diagnostic biomarkers for non-small cell lung cancer: present and future perspectives
Xiaoke Chen, Shuqian Yu, Junqiang Fan
The role of deep learning and radiomic feature extraction in cancer-specific predictive modelling: a review
Alanna Vial, David Stirling, Matthew Field, Montserrat Ros, Christian Ritz, Martin Carolan, Lois Holloway, Alexis A. Miller
Exposing cancer with CRISPR-Cas9: from genetic identification to clinical therapy
Ping Fan, Zhi-Yao He, Ting Xu, Kevin Phan, George G. Chen, Yu-Quan Wei

Case Report

A rare unilateral giant fibroadenoma of the breast during pregnancy and lactation
Haidong Cui, Jian Liu, Shufang Hu, Jufeng Guo, Aizhai Xiang
Specific skin changes induced by chemotherapy
Lin Ding, Qing-Jian Li, Ying Wang, Zhuo-Fei Bi, Jie Chai, Zhi-Min Jiang, Phei-Er Saw, Hai Hu, He-Rui Yao

Letter to the Editor

Does delayed treatment affect the survival of patients with hepatocellular carcinoma?
Ying-Yang Liao, Jie Ou, Cheng-Piao Luo, Ning-Fu Peng, Jian-Hong Zhong

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Original Article

Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr

Original Article

Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report



Original Article




Case report


Mini-Review