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Original Article

Expression of Syndecan-2 in gastric adenocarcinoma and its effect on tumorigenesis in vitro
Jingwen Wang, Chen Lu, Jiayan Chen, Xi Chen, Shiwen Wang, Xingang Lu, Xi Tang
MiRNA-516b inhibits ameloblastoma cell proliferation and invasion by regulating MYCBP/c-myc/RECK/MMP pathway
Liming Duan, You Wu, Yancan Liang, Di Wan, Daming Zhang, Bin Zhang
The up-regulation of TANK-binding kinase 1 in head and neck squamous cell carcinoma
Yaping Wang, Zhongyuan Lu, Zhangwei Hu, Anyuan Zheng, Fei Wang, Yong Xu, Bokui Xiao, Chen Chen, Zezhang Tao
Tumor volumes predict prognosis in head and neck cancer: a meta-analysis
Ke Xie, Jianqiang Chen, Jianding Zou, Liangyu Chen, Liang Gong
Hyperpolarization-activated cyclic nucleotide-gated gene signatures and poor clinical outcome of cancer patient
Nam Nhut Phan, Tung Thanh Huynh, Yen-Chang Lin
LAPTM4B-35 expression was correlated with favorable postoperation survival in pancreatic cancer patients
Can Cui, Jianhui Wu, Xiaojing Cheng, Liang Yan, Xiaoya Guan, Bin Dong, Min Zhao, Xiuyun Tian, Chunyi Hao
Microsatellite alteration in plasma DNA discriminates multiple primary lung cancer from metastatic lung cancer
Long Tian, Xin Wang, Rujun Zeng, Cheng Shen, Yutian Lai, Kun Zhou, Guowei Che
Metabolic volume parameters based on different thresholds with baseline 18F-FDG PET/CT as prognostic factors for survival in stage III non-small cell lung cancer
Yamin Jie, Xue Meng, Anxin Gu, Xiaorong Sun, Jinming Yu
Co-targeting Aurora kinase A and Bcl-2 synergistically inhibits the viability in double-hit lymphoma cells
Ling-Zhe Kong, Xiao-Hui Jia, Zheng Song, Li-Hua Qiu, Lan-Fang Li, Zheng-Zi Qian, Shi-Yong Zhou, Xian-Ming Liu, Xiu-Bao Ren, Bin Meng, Kai Fu, Ping Wang, Xian-Huo Wang, Hui-Lai Zhang
Expression of HGF, MET and mutated EGFR in EGFR mutated lung adenocarcinoma and their clinical significance
Shu-Ling Zhang, Xin Sun, Li Sun, Zhi-Cheng Xiong, Jie-Tao Ma, Le-Tian Huang, Cheng-Bo Han
HBx deletion-mutant combined with the reverse transcriptase enzyme/s* mutation is involved in HBV mediated liver cell proliferation and apoptosis
Yi Ouyang, Lei Fu, Shifang Peng, Deming Tan, Xiaoyu Fu
The polymorphism of JAK2 rs56118985 may be a predictive marker of the treatment responses of acute myeloid leukemia patients
Peipei Xu, Miaoxin Peng, Di Zhou, Xiaoyan Shao, Qiguo Zhang, Rongfu Zhou, Jiangyan Xu, Jian Ouyang, Bing Chen
A comparative dosimetric study of seven radiation techniques for breast cancer after mastectomy and immediate breast reconstruction
Hua Zheng, You-Qun Lai, Yuan Zhou, Shan-Yu Chen, Jia-Yuan Sun, Feng-Yan Li, Qin Lin, San-Gang Wu, Zhen-Yu He
A clinical comparison of short-term efficacy, survival and adverse reactions between raltitrexed/cisplatin-based and docetaxel/cisplatin-based concurrent chemoradiotherapy in the treatment of advanced esophageal squamous cell carcinoma
Xin-Lei Gong, Xin-Chen Sun, Xiao-Lin Ge, Yao Wang
Role of a selective cyclooxygenase-2 inhibitor on pain and enhanced recovery after open hepatectomy: a randomized controlled trial
Mei-Ting Chen, Bao Jin, Shun-Da Du, Li-Jian Pei, Bo Zhu, Li Yan, Tian-Yi Chi, Hai-Feng Xu, Yong-Chang Zheng, Yi-Yao Xu, Hai-Tao Zhao, Xin Lu, Xin-Ting Sang, Yi-Lei Mao, Yu-Guang Huang
Survival outcomes of surgical resection of metastasis to the breast from extra-mammary malignancies: an individual patient data analysis
Yi-Dong Zhou, Bo Pan, Ru Yao, Qian-Qian Xu, Jie Shi, Qing-Li Zhu, Shan-Shan You, Zhi-Yong Liang, Qiang Sun
Comparison of portal vein embolization, portal vein ligation, associating liver partition and portal vein ligation for staged hepatectomy in cases with a small future liver remnant: a network meta-analysis
Hanchun Huang, Wenjun Liu, Anqiang Wang, Jin Bian, Shanshan Wang, Liangcai Wu, Jianzhen Lin, Yiyao Xu, Xinting Sang, Haitao Zhao
LncRNA TUSC7 affects malignant tumor prognosis by regulating protein ubiquitination: a genome-wide analysis from 10,237 pan-cancer patients
Xiaoshun Shi, Yusong Chen, Allen M. Chen, Xiaobing Le, Kailing Huang, Jingyi Chen, Shuai Wen, Haikang Zeng, Cheng Chen, Jin Li

Review Article

Circular RNAs in cancer: old tree with new flowers
Yan Cao, Hui Cong, Xudong Wang, Rongrong Jing, Shaoqing Ju

Case Report

A review of pituitary abscess: our experience with surgical resection and nursing care
Xiaoyang Ling, Tongming Zhu, Zhengxiang Luo, Yansong Zhang, Yongyan Chen, Penglai Zhao, Yibing Si
Immunohistochemical findings in small cell neuroendocrine carcinoma of the cervix: a report of two cases
Hongrun Zhou, Lin Tao, Dongdong Chen, Ruijuan Gao, Lili Zhao, Ganxiong Li, Hongzhi Chen, Yan Ren, Xiaoyu Li, Yixun Wang, Lijuan Pang

Study Protocol

Effectiveness of digital breast tomosynthesis (3D-mammography) in population breast cancer screening: a protocol for a collaborative individual participant data (IPD) meta-analysis
Nehmat Houssami, Kristina Lång, Solveig Hofvind, Sophia Zackrisson, Daniela Bernardi, Kylie Hunter, Lisa Askie, Per Skaane

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Original Article

Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr

Original Article

Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report



Original Article


Review Article


Original Articles


Mini-Review