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New Impact Factor for Translational Cancer Research: 0.986

We are pleased to announce that the Translational Cancer Research (TCR) has attained its latest impact factor update for the 2019 citation year: 0.986. More >>

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others),... More >>

Implementation of transparent peer review at Translational Cancer Research

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a... More >>

Original Article

Immunohistochemical detection of cancer-associated fibroblasts in gastrointestinal cancer as a potential prognostic biomarker of survival: meta-analysis
Junjie Gu, Chenyu Wang, Xiuxiu Xu, Lin Zhao, Jianfeng Zhou, Chunmei Bai, Zhao Sun
Epithelial-mesenchymal transition classification of circulating tumor cells in lung and colon cancer patients: potential role in clinical practice
Jinman Fang, Weimin Wang, Jie Fang, Huanzhong Wang, Lin Lin, Fei Li, Qiuyan Sun, Feifei Li, Jian Qi, Xiaojun Sun, Xing-Xing Huo, Shujie Wang, Hongzhi Wang, Bo Hong, Qingmei Deng, Jinfu Nie
TM9SF4 expression in tumor tissues: a novel diagnostic biomarker for gastrointestinal tumors
Paolo Guazzi, Davide Zocco, Sergejs Isajevs, Natasa Zarovni, Laura Bianciardi, Mart Toots, Armands Sivins, Marcis Leja, Antonio Chiesi, Francesco Lozupone
Chromodomain-helicase-DNA-binding protein 1-like (CHD1L) silencing inhibits gastric cancer cell proliferation, invasion, and migration
Dinuo Li, Chen Li, Yu Wang, Yubin Wang, Qiang Li, Lei Wang
Polo-like kinase 1 is involved in apoptosis, invasion, and metastasis of pancreatic ductal adenocarcinoma
Yonghuan Mao, Ling Xi, Quan Li, Xinhua Zhang, Chunzhao Yu
Application of CT radiomics features to predict the EGFR mutation status and therapeutic sensitivity to TKIs of advanced lung adenocarcinoma
Chunsheng Yang, Weidong Chen, Guanzhong Gong, Zhenjiang Li, Qingtao Qiu, Yong Yin
Clinicopathological features and outcomes of major salivary gland mucoepidermoid carcinoma: do they vary in different age groups
Yujiao Li, Chaosu Hu
A preliminary study of the clinical significance of folate receptor- positive circulating tumor cell in the management of hepatobiliary- pancreatic cancers
Yong-gang He, Lu Zheng, Ming-fa Gao, Yi-chen Tang, Yu-ming Li, Kai-huan Yu, Jing Li, Xiao-bing Huang
Nomogram for predicting the risk of bone metastasis in breast cancer: a SEER population-based study
Li-Jun Ye, Huan-Dan Suo, Chun-Yan Liang, Lei Zhang, Zi-Ning Jin, Cheng-Ze Yu, Bo Chen
Screening and verifying key genes with poor prognosis in colon cancer through bioinformatics analysis
Buyuan Dong, Mengyu Chai, Hao Chen, Qian Feng, Rong Jin, Sunkuan Hu
Identification of a 7-mRNA signature as a prognostic biomarker in pediatric osteosarcoma
Tingting Cui, Jiantao Guo, Chunxiang Jin
Long-term outcome and prognostic nomogram for intrahepatic cholangiocarcinoma after thermal ablation: a retrospective study
Yang Wang, Zhuhui Yuan, Bozhi Liu, Hui Chen, Tian Yin, Jiasheng Zheng, Wei Li
Autonomic nerve regulation for prostate cancer: study based on the tissue transcriptional analysis
Fang Liu, Huan Xu, Junyi Chen, Bo Yang, Lin Zhao, Jin Ji, Zhi Cao, Ji Lyu, Fubo Wang
Overexpression of SEZ6L2 predicts poor prognosis in patients with cholangiocarcinoma
Ziming Wang, Jiaming Lai, Lijian Liang, Xiaoyu Yin, Qian Wang, Quanyong Cheng, Chaoxu Zheng
The efficacy and safety of immune checkpoint inhibitors combined with antiangiogenic drugs in renal cell carcinomas: a systematic review and meta-analysis
Qian He, Jiayi Li, Chi Zhang, Sheng Tang, Qinglan Ren
The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review
Jun Zhang, Weipeng Shao, Zhenrong Zhang, Deruo Liu
Development and validation of a clinical prediction model to estimate the probability of malignancy in solid pancreatic lesions and explore its value in the atypical diagnostic category after endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA)
Ning Wei, Rui Hua Shi, Ting Yu
Mutation of PD-1 immune receptor tyrosine-based switch motif (ITSM) enhances the antitumor activity of cytotoxic T cells
Tongbing Qi, Juan Fu, Wen Zhang, Weitong Cui, Xiaosong Xu, Jianmei Yue, Qinglu Wang, Xuewen Tian
Limonin inhibits angiogenesis and metastasis of human breast cancer cells by suppressing the VEGFR2/IGFR1-mediated STAT3 signaling pathway
Jing Chen, Bo-Xia Liu, Qin Shen, Na Li, Jun Ling, Min Xiao, Hai-Yan Jiao, Tao Li
Tolerance and outcome of hypofractionated post-mastectomy radiotherapy among elderly breast cancer patients in a specialized center in Nigeria
Usman Malami Aliyu, Awosan Kehinde
Identification of key candidate genes associated with prognosis of lung adenocarcinoma by integrated bioinformatical analysis
Jinghang Li, Yanxiu Li, Min Jin, Lin Huang, Xiaowei Wang
Cognitive impairment is related to a reduced count of T-lymphocytes in older patients diagnosed with non-small cell lung cancer (NSCLC)
Teresa Soria-Comes, Vicente Palomar-Abril, María Martín Ureste, Javier García Sánchez, Josefa Esperanza Marco Buades, María José Fernández Llavador, Amparo López Gabaldón, Mar González Jurado, Inmaculada Concepción Maestu Maiques
Expression profiling analysis reveals molecular mechanism of Lnc00675 downregulation promoting cell apoptosis in acute myeloid leukemia U937 cells
Miao Miao, Mengqi Li, Zhuogang Liu, Wei Yang, Chen Wang, Rong Hu
Fibroblast growth factor receptor 4 as a prognostic indicator in triple-negative breast cancer
Wei Wei, Shiyu Cao, Jing Liu, Yuhang Wang, Quanfu Song, Leha A, Shanshan Sun, Xianyu Zhang, Xiaoshuan Liang, Yongdong Jiang
Whole-exome sequencing in cervical adenocarcinoma in mainland Chinese patients
Xinxin Zhang, Jing Guo, Yaping Cai, Xiugui Sheng
Fluconazole is as effective as other anti-mold agents in preventing early invasive fungal disease after allogeneic stem cell transplantation: assessment of antifungal therapy in haematological disease in China
Yuqian Sun, Jiong Hu, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang
Computed tomography manifestations and pathological features of neuroendocrine carcinoma in uncommon sites
Fan Yang, Zhi Wen
Tanshinone IIA induces autophagy in colon cancer cells through MEK/ERK/mTOR pathway
Jun Qian, Yi Cao, Junfeng Zhang, Lingchang Li, Juan Wu, Guoli Wei, Jialin Yu, Jiege Huo
Adjuvant radiotherapy may have significant survival benefits for gastric cancer patients with 1-29 lymph nodes retrieved
Siyi Wu, Yuxin Chu, Qinyong Hu, Qibin Song
Construction of nomograms for nasopharyngeal carcinoma containing primary tumor size and SEER stage
Guangrong Yang, Bangyu Luo, Qiao Yang, Mingjing Chen, Xiu Yang, Jianguo Sun
Effect of breast cancer as the first or second primary cancer on the prognosis of women with thyroid cancer: a SEER database analysis
Jianglong Huang, Yihui Huang, Ling Zhou, Sichao Chen, Danyang Chen, Wei Wei, Chao Zhang, Min Wang, Wei Zhou, Wen Zeng, Zeming Liu, Liang Guo
Is there an efficacy-effectiveness gap between randomized controlled trials and real-world studies in colorectal cancer: a systematic review and meta-analysis
Xiao Zhang, Shihui Fu, Rui Meng, Yu Ren, Ye Shang, Lei Tian
MiR-185-3p regulates epithelial mesenchymal transition via PI3K/Akt signaling pathway by targeting cathepsin D in gastric cancer cells
Cheng Huang, Yang-Jie Wu, Wei-Feng He, Shun-Li Zhao, Yan-Yi Ouyang, Xiao-Hong Ai, Zhi-Qi Liu, San-Yuan Tang
Incidence features of second primary malignancy among gastric cancer survivors, 1992–2012
Shuai Li, Yiyang Luo, Qi Hou, Huaqing Chu, Hui Zheng
Circulating methylated Septin 9 and ring finger protein 180 for noninvasive diagnosis of early gastric cancer
Chang-Qi Cao, Lin Chang, Qi Wu
Regional lymph node involvement is associated with poorer survivorship in patients with upper extremity osteosarcoma than with lower extremity osteosarcoma: a SEER analysis
Xianbiao Xie, Ziliang Zeng, Jian Tu, Hao Yao, Yiying Bian, Qinglin Jin, Dongming Lv, Bo Wang, Jingnan Shen
Can ACEI/ARB prevent the cardiotoxicity caused by chemotherapy in early-stage breast cancer?—a meta-analysis of randomized controlled trials
Haoran Dong, Litong Yao, Mozhi Wang, Mengshen Wang, Xinyan Li, Xiangyu Sun, Xueting Yu, Jingyi Guo, Xiang Li, Yingying Xu
A clinical model to predict the risk of liver metastases in newly diagnosed ovarian cancer: a population-based study
Yufei Yuan, Ruoran Wang, Fanfan Guo, Yidan Zhang, Hongyan Wang, Xia Li, Gui-Qin Bai
Nomogram for predicting axillary lymph node status after neoadjuvant chemotherapy in breast cancer
Mengshen Wang, Mozhi Wang, Zhenning Wang, Yongxi Song, Peng Gao, Pengliang Wang, Chong Wang, Xueting Yu, Fengheng Wei, Jingyi Guo, Yingying Xu
The prognostic role of a combined fibrinogen and inflammation- based index in patients with metastatic breast cancer
Qiuge Liu, Shuangshuang Fang, Shanshan Liang, Jinyan Lv, Gang Wang, Rongbin Tang, Xuening Ji, Tong Zhao, Jiaoyang Li, Lu Xu, Lianli Ma, Ruoyu Wang, Heming Li
Knockout of STK10 promotes the migration and invasion of cervical cancer cells
Lu Zhang, Shun-Yuan Lu, Rui Guo, Jin-Xia Ma, Ling-Yun Tang, Yan Shen, Chun-Ling Shen, Li-Ming Lu, Zhu-Gang Wang, Jie Liu, Hong-Xin Zhang
Survival and prognostic factors in primary vaginal cancer: an analysis of 2004–2014 SEER data
Jianqin Huang, Meiyu Cai, Zhiling Zhu
Web-based nomograms for predicting the prognosis of adolescent and young adult skin melanoma, a large population-based real- world analysis
Chen Yang, Fei Liao, Li Cao
Choice of surgical procedures for patients with stage T1 carcinoma of the papilla of Vater: a retrospective study
Zongting Gu, Zongze Li, Wenlong Yu, Yongjie Zhang, Chengfeng Wang
Intraoperative radiotherapy versus whole‑breast external beam radiotherapy, and other factors associated with the prognosis of early breast cancer treated with breast-conserving surgery and radiotherapy: a retrospective study from SEER database
Ming-Shuai Sun, Hong-Jin Liu, Yin-Hua Liu, Ling Xu, Jing-Ming Ye
Robot-assisted laparoscopic partial nephrectomy is a safe and effective option for clinical T2 renal cell carcinoma: a case-series from single-institution
Gongwei Long, Man Liu, Yucong Zhang, Guoliang Sun, Wei Ouyang, Jun Yang, Zhihua Wang, Zheng Liu, Wei Guan, Zhiquan Hu, Shaogang Wang, Heng Li
Screening of hub genes associated with prognosis in non-small cell lung cancer by integrated bioinformatics analysis
Yu Zeng, Nanhong Li, Riken Chen, Wang Liu, Tao Chen, Jinru Zhu, Mingqing Zeng, Junfen Cheng, Jian Huang
KIF4A is a promising prognostic marker and correlates with immune infiltration in clear cell renal cell carcinoma
Canxuan Li, Jie Chen, Zhijian Su
The diagnostic and prognostic value of nuclear matrix protein 22 in bladder cancer
Xingxing Tang, Yudong Cao, Jia Liu, Shuo Wang, Yong Yang, Peng Du
Paeonol induces antitumor effects in hepatocellular carcinoma cells through survivin via the cyclooxygenase-2/prostaglandin E2 signaling pathway
Hao Liu, Congjun Zhang
High neural precursor cell-expressed developmentally down-regulated 9 expression is a poor prognostic indicator for osteosarcoma
Jinyi Feng, Yang Gu, Linquan Zhou, Gang Rui, Wenge Liu
Distal pancreatectomy with en bloc celiac axis resection does not improve the R0 rate or median survival time of patients with locally advanced pancreatic cancer: a systematic review and meta-analysis
Qingbo Feng, Zechang Xin, Yan Du, Feiyu Mao, Ling Li, Huamin Zhai, Jie Yao
Long noncoding RNA MAFG-AS1 facilitates bladder cancer tumorigenesis via regulation of miR-143-3p/SERPINE1 axis
Xi Sun, Yi Cai, Xiheng Hu, Miao Mo, Cheng Zhao, Wei He, Yangle Li
Applied research of a four-dimensional CT localization technique in radiotherapy and treatment planning for early lung cancer
Gang Wang, Xiwen Zhu, Fan Zhang, Jing Liu, Lu Yue, Lihua Deng, Mi Zhou
MiR-449a-5p regulates the proliferation of esophageal carcinoma cell by targeting B-cell lymphoma 2
Tao Jiang, Ruixing Zhao, Yanyan Du, Zhihua Shi, Hongchun Cheng
Expression of YAP in endometrial carcinoma tissues and its effect on epithelial to mesenchymal transition
Yun Cheng, Hailiang Huang, Yang Han, Ying Zhu
Comprehensively analyze the expression and prognostic role for ten-eleven translocations (TETs) in acute myeloid leukemia
Yan Huang, Jie Wei, Xunjun Huang, Weijie Zhou, Yuling Xu, Dong-Hong Deng, Peng Cheng
Analyzing the key gene expression and prognostics values for acute myeloid leukemia
Lingling Shi, Yan Huang, Xunjun Huang, Weijie Zhou, Jie Wei, Donghong Deng, Yongrong Lai
Identifying four DNA methylation gene sites signature for predicting prognosis of osteosarcoma
Xijun Zhang, Yongjun Zheng, Gaoshan Li, Changying Yu, Ting Ji, Shenghu Miao

Original Article

Effect of fasting therapy in chemotherapy-protection and tumorsuppression: a systematic review
Lei Sun, Yong-Jiang Li, Xi Yang, Ling Gao, Cheng Yi

Review Article

The management of brain necrosis as a result of SRS treatment for intra-cranial tumors
Uresh Patel, Ankush Patel, Charles Cobb, Tara Benkers, Sandra Vermeulen
Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai
Magnetic resonance imaging of pancreatic malignancy
Mellena D. Bridges
EGFR and HER2: is there a role in ovarian cancer?
Eleonora Teplinsky, Franco Muggia
Advances on immunotherapy in breast cancer
Kanthi Athreya, Sonia Ali
Targeting the folate receptor for the treatment of ovarian cancer
Robert J. Lutz
Computational resources for radiomics
Laurence E. Court, Xenia Fave, Dennis Mackin, Joonsang Lee, Jinzhong Yang, Lifei Zhang

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger
HNF1A, KRT81, and CYP3A5: three more straws on the back of pancreatic cancer?
Andrew J. Scott, John C. Wilkinson
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa
Disulfiram combats cancer via crippling valosin-containing protein/p97 segregase adaptor NPL4
Nan Ding, Qianzheng Zhu
Hypofractionated whole breast irradiation is cost-effective—but is that enough to change practice?
Apar Gupta, Nisha Ohri, Bruce G. Haffty
Cost-effectiveness in managing skeletal related events in breast cancer: a strategy of less-intense dosing schedule of bone modifying agents
Sri Harsha Tella, Anuhya Kommalapati, Ryan K. Singhi
CRISPR-based genetic interaction maps inform therapeutic strategies in cancer
Poornima Ramkumar, Martin Kampmann
Smooth sailing for immunotherapy for unresectable stage III nonsmall cell lung cancer: the PACIFIC study
Melin J. Khandekar, Rakesh Jain
The evolving role of molecular profiling in prostate cancer: basal and luminal subtyping transcends tissue of origin
Omar Y. Mian, Rahul D. Tendulkar, Mohamed E. Abazeed
Serrated polyposis: the problem of definition and its relationship to the population at risk for syndrome-related colorectal cancer
Joanne P. Young, Timothy J. Price, Susan Parry
Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response
R. Dixon Dorand, Agne Petrosiute, Alex Y. Huang
Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomes
Theresa L. Whiteside
TIC10/ONC201—a potential therapeutic in glioblastoma
Georg Karpel-Massler, Markus D. Siegelin
IDH mutational status and the immune system in gliomas: a tale of two tumors?
Bryan D. Choi, William T. Curry
ONC201: a new treatment option being tested clinically for recurrent glioblastoma
Marie D. Ralff, Amriti R. Lulla, Jessica Wagner, Wafik S. El-Deiry
When better still might not be good enough
Waldemar Debinski
Androgen receptor antagonism and impact on inhibitors of androgen synthesis in prostate cancer therapy
Vincent C. O. Njar
Co-inhibitory receptor programmed cell death protein 1 targets co-stimulatory CD28
Leonardo Chicaybam, Prasad S. Adusumilli
Exosome mediated phenotypic changes in lung cancer pathophysiology
Yoshihisa Shimada, John D. Minna
Signatures of field cancerization: a step towards earlier detection of esophageal adenocarcinoma
Aaron D. DeWard, Rebecca J. Critchley-Thorne
From tumorigenesis to microenvironment and immunoregulation: the many faces of focal adhesion kinase and challenges associated with targeting this elusive protein
Felicia L. Lenzo, William G. Cance
New incriminating evidence against IGF2
Wen Ding, Lina A. Shehadeh
Targeting cancer with tumor-specific therapeutic strategies—metabolic reprogramming beyond the Warburg effect
Paul Grippo, Ajay V. Maker
Branched chain amino acid metabolism and cancer: the importance of keeping things in context
Elizabeth M. Selwan, Aimee L. Edinger
RIPK1-TRAF2 interplay on the TNF/NF-κB signaling, cell death, and cancer development in the liver
Satomi Yamamoto, Tomoo Iwakuma
Genome-based modeling for adjusting radiotherapy dose (GARD)-a significant step toward the future of personalized radiation therapy
Michael J. Baine, Chi Lin
Rogue one: another faction of the Wnt empire implicated in assisting GBM progression
Riasat Ahsan, Shivani Baisiwala, Atique U. Ahmed
Normalizing tumoral vessels to treat cancer: an out-of-the-box strategy involving TIE2 pathway
Juan Fueyo, Mohammad B. Hossain, Teresa Nguyen, Candelaria Gomez-Manzano
Exploring gold nanoparticle interactions with proteins and the tumor microenvironment in biological systems
Li Tian, Ashley Chang, Marites P. Melancon
IL-6, cancer and cachexia: metabolic dysfunction creates the perfect storm
James P. White
Low-frequency ultrasound may improve drug penetration in colonic mucosa
Qiubing Chen, Bo Xiao, Didier Merlin
Dividing and conquering the variation among variants in EML4-ALK lung cancer
Trever G. Bivona
Unlocking the epigenetic code of T cell exhaustion
Jiazhu Wu, Huidong Shi
KDM1 links nuclear GSK3β to epigenetic alterations
Weijie Guo, Binhua P. Zhou
Moving the mountain in advanced non-small-cell lung cancer: evolving immunotherapies for a dire disease
Deepa Rangachari, Daniel B. Costa
Taming immune suppressor: application of myeloid-derived suppressor cells in anti-cancer gene therapy
Bhagelu R. Achyut, Ali S. Arbab
Neuroendocrine differentiation in prostate cancer: key epigenetic players
Karishma Gupta, Sanjay Gupta
PD-L1 is a diverse molecule regulating both tumor-intrinsic signaling and adaptive immunosuppression
Kim A. Brogden, Shireen Vali, Taher Abbasi
Mesenchymal stromal cells and interferon α (IFNα) in cancer immunotherapy
Diana Saleiro, Sara G. Radecki, Leonidas C. Platanias
The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies
Keith T. Schmidt, William D. Figg
Information-dense analysis for information-dense understanding
Nikola A. Ivica, Mandeep Kaur, Guangan Hu, Jianzhu Chen
The “liquid biopsy” in non-small cell lung cancer—not quite ready for prime time use
Angel Qin, Nithya Ramnath
Immune infiltration, glioma stratification, and therapeutic implications
Manny D. Bacolod, Sarmistha Talukdar, Luni Emdad, Swadesh K. Das, Devanand Sarkar, Xiang-Yang Wang, Francis Barany, Paul B. Fisher
Balancing redox stress: anchorage-independent growth requires reductive carboxylation
Clint.A Stalnecker, Ahmad.A Cluntun, Richard.A Cerione
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy
Fabiana Perna, Michel Sadelain
Harnessing protein kinase A activation to induce mesenchymal-epithelial programs to eliminate chemoresistant, tumor-initiating breast cancer cells
Alex J. Gooding, William P. Schiemann
Actionable intelligence provided by pancreatic cancer genomic landscape: are targets for curative therapy on the map?
Nathan A. Berger
Microtubule targeting agents in glioma
Anda-Alexandra Calinescu, Maria G. Castro
Moving molecular subtypes to the clinic in gastric cancer
Joseph Chao, Jeeyun Lee, Samuel J. Klempner
Intraoperative subtyping of lung adenocarcinoma: an unmet need
Nurlan Aliyev, Yusuke Takahashi, Shaohua Lu, Marissa Mayor, Prasad S. Adusumilli
Emerging roles of FGF signaling in hepatocellular carcinoma
Nana Zheng, Wenyi Wei, Zhiwei Wang
Tregs, Helios and tumor immunity: the sun has not yet risen
Angela M. Thornton, Ethan M. Shevach
Immune checkpoint regulator: a new assignment proposed for the classic adhesion molecule P-selectin glycoprotein ligand-1
Jiaxuan Chen, Carolyn A. Haller, Elliot L. Chaikof
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components
Brandon J. Manley, James J. Hsieh
Multimodal action of ONECUT2 in driving neuroendocrine prostate cancer
Salma Kaochar, Nicholas Mitsiades
(R)-2-hydroxyglutarate drives immune quiescence in the tumor microenvironment of IDH-mutant gliomas
Leland G. Richardson, Bryan D. Choi, William T. Curry
Are lung adenocarcinoma mutations shaping the immune microenvironment?
Philippe Rochigneux, Edward B. Garon
On the subventricular zone origin of human glioblastoma
Akshitkumar M. Mistry
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
Bevacizumab as an adjuvant therapy for glioblastoma in elderly patients: the facts
Kristopher A. Lyon, Jason H. Huang
Targeting ROS1 rearrangements in non-small cell lung cancer with crizotinib and other kinase inhibitors
Kartik Sehgal, Rushad Patell, Deepa Rangachari, Daniel B. Costa

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer
Hui-Yi Lin, Chia-Ho Cheng, Dung-Tsa Chen, Y. Ann Chen, Jong Y. Park
How are lung cancer risk perceptions and cigarette smoking related?—testing an accuracy hypothesis
Lei-Shih Chen, Kimberly A. Kaphingst, Tung-Sung Tseng, Shixi Zhao
Alcohol intake patterns for cancer and non-cancer individuals: a population study
Hui-Yi Lin, Paige Fisher, Darian Harris, Tung-Sung Tseng
Application of Bayesian predictive probability for interim futility analysis in single-arm phase II trial
Dung-Tsa Chen, Michael J. Schell, William J. Fulp, Fredrik Pettersson, Sungjune Kim, Jhanelle E. Gray, Eric B. Haura
Quantitative ubiquitylome analysis and crosstalk with proteome/ acetylome analysis identified novel pathways and targets of perifosine treatment in neuroblastoma
Min Jiang, Zhongyan Hua, Yudi Dong, Zhihui Liu, Carol J. Thiele, Zhijie Li

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer
Prostate cancer: unmet clinical needs and RAD9 as a candidate biomarker for patient management
Howard B. Lieberman, Alex J. Rai, Richard A. Friedman, Kevin M. Hopkins, Constantinos G. Broustas
Exosomal lncRNAs as new players in cell-to-cell communication
Mihnea Dragomir, Baoqing Chen, George A. Calin
Repurposing DNA repair factors to eradicate tumor cells upon radiotherapy
Souparno Bhattacharya, Aroumougame Asaithamby
Translational research in radiation-induced DNA damage signaling and repair
Jac A. Nickoloff, Mary-Keara Boss, Christopher P. Allen, Susan M. LaRue
Genetically engineered mouse models for studying radiation biology
Katherine D. Castle, Mark Chen, Amy J. Wisdom, David G. Kirsch
Renal cell carcinoma: the search for a reliable biomarker
Nicholas J. Farber, Christopher J. Kim, Parth K. Modi, Jane D. Hon, Evita T. Sadimin, Eric A. Singer
Advances on immunotherapy in genitourinary and renal cell carcinoma
Gregory P. Botta, Eric Granowicz, Carrie Costantini
The role of novel immunotherapies in non-Hodgkin lymphoma
Allyson Pishko, Sunita D. Nasta
MDMX under stress: the MDMX-MDM2 complex as stress signals hub
Anna de Polo, Varunika Vivekanandan, John B. Little, Zhi-Min Yuan
Do p53 stress responses impact organismal aging?
Paul Hasty, Judith Campisi, Z. Dave Sharp
Pharmacological targeting of mutant p53
Samuel Kogan, Darren Carpizo
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Michael I. Carr, Stephen N. Jones
Regulation of cytotoxic T-cell responses by p53 in cancer
Mitchell W. Braun, Tomoo Iwakuma
The IGF-1R/AKT pathway determines cell fate in response to p53
Lei Duan, Carl G. Maki
Intra molecular interactions in the regulation of p53 pathway
Jiandong Chen
TP53 mutations in epithelial ovarian cancer
Yu Zhang, Lan Cao, Daniel Nguyen, Hua Lu
Modulation of the p53 family network by RNA-binding proteins
Chris Lucchesi, Jin Zhang, Xinbin Chen
Radiomics in head and neck cancer: from exploration to application
Andrew J. Wong, Aasheesh Kanwar, Abdallah S. Mohamed, Clifton D. Fuller
Prostate cancer radiomics and the promise of radiogenomics
Radka Stoyanova, Mandeep Takhar, Yohann Tschudi, John C. Ford, Gabriel Solórzano, Nicholas Erho, Yoganand Balagurunathan, Sanoj Punnen, Elai Davicioni, Robert J. Gillies, Alan Pollack
Positron emission tomography/computerized tomography for tumor response assessment—a review of clinical practices and radiomics studies
Wei Lu, Wengen Chen
The emerging field of radiomics in esophageal cancer: current evidence and future potential
Peter SN. van Rossum, Cai Xu, David V. Fried, Lucas Goense, Laurence E. Court, Steven H. Lin
Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat’s in the fire
Jung H. Suh, Julie D. Saba
Computational methods and opportunities for phosphorylation network medicine
Yian Ann Chen, Steven A. Eschrich
Role of the androgen signaling axis in genitourinary malignancies
Brian M. Shinder, Adam Shupe, Geun Taek Lee, Mark N. Stein, Isaac Y. Kim, Eric A. Singer

Commentary

Molecular heterogeneity of localized prostate cancer: more different than alike
Jeffrey J. Tosoian, Emmanuel S. Antonarakis
A crowded, but still varied, space: brigatinib in anaplastic lymphoma kinase-rearranged non-small cell lung cancer
Sawsan Rashdan, David E. Gerber
MOAP-1, UBR5 and cisplatin resistance in ovarian cancer
Scott T. Eblen, Amber Bradley
Exportin 1/chromosome region maintenance 1 as a therapeutic target for lung cancer
Weimin Gao
The role of tumor-derived exosomes in epithelial mesenchymal transition (EMT)
Theresa L. Whiteside
[18F]-choline PET/CT as an imaging biomarker for primary liver cancers
Zhenghong Lee
Empiric H. pylori therapy—10-day concomitant, bismuth quadruple or 14-day triple therapy: none is best
Yoshio Yamaoka, David Y. Graham
JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function
Theodoros Karantanos, Vassiliki A. Boussiotis
Cisplatin, etoposide, and irinotecan for relapsed small-cell lung cancer
Angel Qin, Gregory P. Kalemkerian
Helicobacter pylori vacuolating cytotoxin and gastric cancer risk: reconsidered
Muhammad Miftahussurur, Yoshio Yamaoka, David Y. Graham
Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells
Praveen Kumar Vemula, Venkatakrishna Rao Jala
Helios—controller of Treg stability and function
Claire Chougnet, David Hildeman
Directing abiraterone metabolism: balancing the scales between clinical relevance and experimental observation
Jon K. Obst, Marianne D. Sadar
Novel insights into the oncogenic function of the SMYD3 lysine methyltransferase
Pawel K. Mazur, Or Gozani, Julien Sage, Nicolas Reynoird
Fat lure: adipocytes attract cancer cells out of the prostate
Alexandra M. Blee, Haojie Huang
Impact of genomic heterogeneity associated with acquired anti-EGFR resistance in colorectal cancers
Guoli Chen, Ming-Tseh Lin

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park
The STAMPEDE trial: paradigm-changing data through innovative trial design
Bradley C. Carthon, Emmanuel S. Antonarakis
Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway
Derek B. Oien, Jeremy Chien, Nikki Cheng
Feed your gut with caution!
Vishal Singh, Beng San Yeoh, Matam Vijay-Kumar
Precision oncology: identifying predictive biomarkers for the treatment of metastatic renal cell carcinoma
Parth K. Modi, Nicholas J. Farber, Eric A. Singer

Letter to the Editors

Multiscale modeling of glioblastoma
Huaming Yan, Mónica Romero-López, Lesly I. Benitez, Kaijun Di, Hermann B. Frieboes, Christopher C. W. Hughes, Daniela A. Bota, John S. Lowengrub

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Case Report



Original Article


Review Article