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Original Article

Pretreatment platelet to lymphocyte ratio is predictive of overall survival in metastatic pancreatic ductal adenocarcinoma
Wanwan Li, Yang Chen, Xuelin Wang, Yan Shi, Guanghai Dai, Xiaorong Li
Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos
Jorge-Aarón Rangel-Méndez, Rodrigo Rubi-Castellanos, Juan-Francisco Sánchez-Cruz, Rosa Esther Moo-Puc
Overexpression of the long non-coding RNA BLACAT1 promotes cell proliferation and invasion in colorectal cancer
Chiwen Bu, Biao Wang, Dong Zhang, Zeqing Mao, Chibin Pu
Nav1.5-E3 antibody inhibits cancer progression
Rui Gao, Ting Cao, Hui Chen, Jing Cai, Ming Lei, Zehua Wang
Expression levels and the prognostic value of long non-coding RNA PVT1 in serum of Han and Uygur gastric cancer patients in Xinjiang, China
Xianxian Ren, Ying Li, Li Yang, Lei Zhang, Yongbiao Xiao, Yu Xi, Xia Li, Feng Li, Dongmei Li, Jinli Zhang
Circulating regulatory T cells from breast cancer patients in response to neoadjuvant chemotherapy
Víctor Sánchez-Margalet, Antonio Barco-Sánchez, Teresa Vilariño-García, Carlos Jiménez-Cortegana, Antonio Pérez-Pérez, Fernando Henao-Carrasco, Juan A. Virizuela-Echaburu, Esteban Nogales-Fernández, María C. Álamo-de la Gala, María A. Lobo-Acosta, Natalia Palazón-Carrión, Adoración Nieto, Luis de la Cruz-Merino
Akt/mTOR and AMPK signaling pathways are responsible for liver X receptor agonist GW3965-enhanced gefitinib sensitivity in nonsmall cell lung cancer cell lines
Qingbo Wang, Bo Shen, Xiaobing Qin, Siwen Liu, Jifeng Feng
Factors associated with de novo metastatic disease in invasive breast cancer: comparison of artificial neural network and logistic regression models
Chunyan Qiu, Lingong Jiang, Yangsen Cao, Can Hu, Yiyi Yu, Huojun Zhang
Diagnosis status and pathological diagnosis derived treatment of elderly lung cancer patients over 75 years old
Guannan Wu, Xiaoling Gu, Dongmei Yuan, Yanwen Yao, Wen Yang, Tangfeng Lv, Yong Song
Targeting liquid-liquid phase separation in pancreatic cancer
Yue Ming, Xia Chen, Yuanpei Xu, Yuanyuan Wu, Chenlu Wang, Tingting Zhang, Renfang Mao, Yihui Fan
Cytotoxic effect of Ad-ephrinA1-caspase-3-T on breast cancer cells in vitro
Yu Huang, Bensi Zhang, Yanjiao Li, Zhuang Li, Qin Zhang, Bin Zhao
Expression and prognostic value of PD-L1 and PD-L2 in ovarian cancer
Chunyan Xue, Dawei Zhu, Lujun Chen, Yun Xu, Bin Xu, Dachuan Zhang, Jingting Jiang
MT-12 inhibits the growth and metastasis of bladder cancer cells via suppressing tumor angiogenesis in vivo and in vitro
Chengxing Xia, Ting Luan, Yan Chen, Ruping Yan, Shunhui Yuan, Delin Yang, Haifeng Wang
Variability of radiomic features extracted from multi-b-value diffusion-weighted images in hepatocellular carcinoma
Jing Zhang, Qingtao Qiu, Jinghao Duan, Guanzhong Gong, Qingjun Jiang, Gang Sun, Yong Yin
GEFT aberrant expression in soft tissue sarcomas
Yang Liu, Shengnan Qi, Lian Meng, Liang Zhang, Yuwen Pang, Wenwen Cui, Juan Du, Zhenzhen Li, Qianqian Liu, Hao Shang, Chunxia Liu, Feng Li
Good response to neoadjuvant chemoradiotherapy predicts good oncological outcome in locally advanced rectal cancer
Chi Zhang, Liping Xu, Qin Qin, Jia Liu, Xinyu Tang, Nan Jiang, Zhaoyue Zhang, Fei Li, Hongyan Cheng, Jiayan Chen, Xinchen Sun
Characterization of microRNA expression profiles by deep sequencing of small RNA libraries in leukemia patients from Naxi ethnic
Zhenglei Shen, Xuezhong Gu, Wenwen Mao, Honghua Cao, Rui Zhang, Yeying Zhou, Kunmei Liu, Lilan Wang, Zhe Zhang, Liefen Yin
The clinical value of circulating tumor DNA detection in advanced non-small cell lung cancer
Xiao Lin, Wentao Dong, Xiaojing Lai, Wei Feng, Xiaofu Yu, Qing Gu, Chunyang Wang, Wen Xiao, Xiao Zheng
miR-30b suppresses the progression of breast cancer through inhibition of the PI3K/Akt signaling pathway by targeting Derlin-1
Jun Zhou, Ai-Zhai Xiang, Ju-Feng Guo, Hai-Dong Cui
Dosimetric comparisons of craniospinal axis irradiation using helical tomotherapy, volume-modulated arc therapy and intensity-modulated radiotherapy for medulloblastoma
Yangqing Sun, Gui Liu, Wen Chen, Taili Chen, Pei Liu, Qian Zeng, Jidong Hong, Rui Wei
The biological functions of LGR5 in promoting non-small cell lung cancer progression
Fei Gao, Jun-Chi Xu, Xin-Ran You, Xin Gao, Jia-Ling Wei, Shu-Xiang Li, Chen-Lu Zhu, Chen Yang
Intensive patient’s care program reduces anxiety and depression as well as improves overall survival in de novo acute myelocytic leukemia patients who underwent chemotherapy: a randomized, controlled study
Hongxia Bao, Yalin Chen, Min Li, Longrui Pan, Xuena Zheng
Expression of centrosomal protein 55 in glioma tissue and the influence on glioma cell functions
Yifan Xu, Tianyu Lu, Wu Xu, Weitao Chen, Weibang Liang, Wei Jin
Alternatively activated NUSAP1 promotes tumor growth and indicates poor prognosis in hepatocellular carcinoma
Chao Shi, Hui Xu, Junyu Liu, Yuanbin Zhong, Xinping Zhang, Xiaoqin Tong, Lunli Zhang, Xiaopeng Li, Libin Deng
Expression of SOX11 and HER2 and their association with recurrent breast cancer
Fu-Wen Wang, Xiang Ao, Shao-Mei Fu
Molecular genetic profiling of small cell lung carcinoma in a Chinese cohort
Zeng Wang, Zhiming Jiang, Hongyang Lu
Effect of hepatitis B virus infection status on liver metastasis of nasopharyngeal carcinoma: a cohort study
Xi Li, Wenyu Wu, Jie Chen, Weilin Ye, Jian Zhang, Ting Wei
Serum biomarkers of inflammation for diagnosis of prostate cancer in patients with nonspecific elevations of serum prostate specific antigen levels
Jose D. Santotoribio, Miguel E. Jimenez-Romero
Transcatheter embolization of hepatocellular carcinoma with epirubicin-loaded DC beads in Chinese patients
Guan-Hui Zhou, Jun-Hui Sun, Yue-Lin Zhang, Tan-Yang Zhou, Chun-Hui Nie, Tong-Yin Zhu, Jing Ai, Sheng-Qun Chen, Bao-Quan Wang, Zi-Niu Yu, Hong-Liang Wang, Li-Ming Wu, Li-Ming Chen, Shu-Sen Zheng
Downregulation of hexokinase 2 improves radiosensitivity of breast cancer
Dan Zhang, Hui Wang, Wenjing Yu, Feng Qiao, Xiaoyu Su, Huiqin Xu

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

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