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Original Article

Effects of ginsenoside Rg3 on apoptosis in A375.S2 melanoma cells
Joo Hyoung Kim, Yong Chan Bae, Jae Woo Lee, June Seok Choi, Seong Hwan Bae
Circular RNA hsa_circ_0002124 promotes hepatocellular carcinoma cell proliferation through the MAPK pathway
Zhigang Fang, Ruifang Fan, Ying Lu, Yanling Sun, Caihan Zhao, Lingling Liu, Xiangfu Liu
NUMB knockdown enhanced the anti-tumor role of cisplatin on ovarian cancer cells by inhibiting cell proliferation and epithelial-mesenchymal transition
Zhao Liu, Shasha Qi, Yibing Fu, Liang Shen, Mingjiang Li, Jiaju Lu, Xingbo Zhao, Hui Zhang
Concordance assessment of Watson for Oncology in breast cancer chemotherapy: first China experience
Hong Pan, Jing Tao, Mengjia Qian, Wenbin Zhou, Yi Qian, Hui Xie, Shengqi Jing, Tingyu Xu, Xin Zhang, Zuolei Dai, Mingliang You, Yun Liu, Xiaoan Liu, Shui Wang
A mechanism of regucalcin knock-down in the promotion of proliferation and movement of human cervical cancer HeLa cells
Xiaolong Li, Yingwen Huang, Pengfei Wang, Wei Song, Qingmei Yao, Qiping Hu, Sufang Zhou
Effect of receptor for hyaluronan-mediated motility inhibition on radiosensitivity of lung adenocarcinoma A549 cells
Chunzi Gao, Shilong Liu, Yanli Wang, Geqi Cha, Xiangying Xu
Risk factors and prediction of postoperative hypoparathyroidism among patients with papillary thyroid carcinoma
Shi-Hang Xue, Zhi-Yu Li, Wei-Zhu Wu
Multiplex fluorescent immunohistochemistry quantitatively analyses microvascular density (MVD) and the roles of TGF-β signalling in orchestrating angiogenesis in colorectal cancer
Lei Yang, Zheng Liu, Tao Wen
Microarray-based differential expression profiling of long noncoding RNAs and messenger RNAs in formalin-fixed paraffin-embedded human papillary thyroid carcinoma samples
Hui-Xian Yan, Jin Du, Jing Fu, Wei Huang, Li-Meng Jia, Pang Ping, Ling Zhao, Ye-Qiong Song, Xiao-Meng Jia, Jing-Tao Dou, Yi-Ming Mu, Fu-Lin Wang, Wen Tian, Zhao-Hui Lyu
The proteomic comparison of peripheral circulation-derived exosomes from the epithelial ovarian carcinoma (EOC) patients and non-EOC subjects
Peng Peng, Wei Zhang, Dongyan Cao, Jiaxin Yang, Keng Shen
STX4 expression is associated with classification, clinical stage and lymphatic metastasis in ovarian cancer
Wenfeng Ye, Dawei Zhu, Bin Xu, Ming Xu, Yingting Liu, Jun Xie, Qi Wang, Jingting Jiang
Rapamycin downregulates NKG2D ligands in acute myeloid leukemia cells via an activation of the STAT3 pathway: a potential mechanism for rapamycin-induced immune escape in leukemia
Zhichao Zhu, Yu Bai, Xuzhang Lu, Jun Ding, Chunjian Qi
BRCA1/2 mutation spectrum in Chinese early-onset breast cancer
Mengjia Shen, Libo Yang, Ting Lei, Lin Xiao, Li Li, Peichuan Zhang, Weiyi Feng, Feng Ye, Hong Bu
Role of PRMT5 in bladder cancer: a comprehensive study
Yingxin Ma, Yucheng Zhong, Weiren Huang
Human cancer cells compensate the genes unfavorable for translation by N6-methyladenosine modification and enhance their translation efficiency
Duan Chu, Lai Wei
Solamargine inhibits proliferation and promotes apoptosis of CM-319 human chordoma cells through suppression of notch pathway
Junqi Liu, Zhenlin Wang, Cong Xu, Yan Qi, Qiuhang Zhang
Long non-coding RNA SNHG17 promotes gastric cancer progression by inhibiting P15 and P16
Cheng Gao, Xinqian Wu, Jing Zhai, Jiajia Shen, Shoulin Wang, Lizong Shen
The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma
Haoran Li, Yanhua Wang, Mao Zhang, Jie Hu, Zixiang Li, Bing Han
miR-1290 inhibits chordoma cell proliferation and invasion by targeting Robo1
Bin Wang, Kai Zhang, Hao Chen, Jian Lu, Guizhong Wu, Huilin Yang, Kangwu Chen
Circulating tumor DNA use in a community oncology practice
Erin D. Chamberlain, Carrie L. Costantini, Marin F. Xavier
Interleukin 6 signaling maintains the stem-like properties of bladder cancer stem cells
Hua Wei
ShRNA-mediated silencing of hTERT promote apoptosis and senescence in human ovarian cancer cells
Chen Su, Yi Luo, Yaying Yang, Yongfen Yi
Prognosis analysis of lobectomy and sublobar resection in patients ≥75 years old with pathological stage I invasive lung adenocarcinoma of ≤3 cm: a propensity score matching-based analysis
Chunji Chen, Qiming Ni, Yubo Shi, Shijie Fu, Xufeng Pan, Yiyang Wang, Jun Yang, Rui Wang
A novel mouse model of orthotopic extrahepatic cholangiocarcinoma confirmed with molecular imaging
Xiaodong Song, Zili Shao, Menglin Han, Huihong Liang
Fumarate hydratase deficiency induces chronic myeloid leukemia progression
Shan Li, Chun Qiao, Lijia Yang, Ming Hong, Yu Fang, Hui Jin, Jianyong Li, Sixuan Qian
LncRNA SNHG1 correlates with higher T stage and worse overall survival, and promotes cell proliferation while reduces cell apoptosis in breast cancer
Lin Sun, Huimin Chu, Hai Li, Yongjun Liu
Prognostic value of primary tumor surgery in de novo stage IV breast cancer patients with different metastatic burdens: a propensity score-matched and population-based study
Yun-Song Yang, Ying-Le Chen, Gen-Hong Di, Yi-Zhou Jiang, Zhi-Ming Shao
Cisplatin chemotherapy-induced miRNA-210 signaling inhibits hepatocellular carcinoma cell growth
Huan Yu, Guangyue Shi
The role of magnetic resonance imaging in detection and surgical treatment of breast intraductal papillomas
Na Hao, Xiaoyan Yuan, Quansheng Wang, Junyong Zhu, Yiqiong Zheng, Yanjun Zhang, Mei Liu, Liuquan Cheng, Xiru Li
MiR-451 suppresses the growth, migration, and invasion of prostate cancer cells by targeting macrophage migration inhibitory factor
Gang Wang, Lixia Yao, Tao Yang, Liuxiong Guo, Shouyi Gu, Junjiang Liu, Kuo Yang
GSTM1 polymorphism in Oncotype DX assay is a potential predictive factor for taxane-based neoadjuvant chemotherapy in estrogen receptor-positive Chinese breast cancer patients
Guochun Zhang, Xueke Qian, Chongyang Ren, Lingzhu Wen, Haitong Lyu, Ning Liao
Identification of RRAS gene related to nasopharyngeal carcinoma based on pathway and network-based analyses
Ruowen Xiao, Lu Shi, Te Yang, Meiyin Zhang, Huiyun Wang, Shijuan Mai

Review Article

The necessity of adjuvant radiotherapy for locally advanced gastric cancer in China
Yongqiang Yang, Pengfei Xing, Ning Zhou, Yongyou Wu, Liyuan Zhang, Ye Tian

Brief Report

County poverty levels influence genome-wide DNA methylation profiles in African American and European American women
Ping-Ching Hsu, Susan Kadlubar, L. Joseph Su, Daniel Acheampong, Lora J. Rogers, Gail Runnells, Pearl A. McElfish, Mario Schootman

Review Article

Common applications of next-generation sequencing technologies in genomic research
Chien-Yueh Lee, Yu-Chiao Chiu, Liang-Bo Wang, Yu-Lun Kuo, Eric Y. Chuang, Liang-Chuan Lai, Mong-Hsun Tsai

Meta-Analysis

Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis
Ping Zhan, Qian Qian, Benjamin Wan, Tristan D. Yan, Li-Ke Yu

Review Articles

Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
Rositsa Dueva, George Iliakis
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
Nanoparticles in radiation therapy: a summary of various approaches to enhance radiosensitization in cancer
Deep Kwatra, Anand Venugopal, Shrikant Anant
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Historical perspective and evolution of charged particle beam therapy
Huan Giap, Bosco Giap
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Role of NBS1 in DNA damage response and its relationship with cancer development
Yuichiro Saito, Hiroko Fujimoto, Junya Kobayashi
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Proton therapy for gastrointestinal cancers
Ted C. Ling, Joseph I. Kang, Jerry D. Slater, Gary Y. Yang
Proton therapy for head and neck cancer: current applications and future directions
Alexander Lin, Samuel Swisher-McClure, Laura Bonner Millar, Maura Kirk, Caitlyn Yeager, Ali Kassaee, Boong-Keng Kevin Teo, Stephen M. Hahn
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou

Original Articles

Comparison of tissue characterization curves for different CT scanners: implication in proton therapy treatment planning
Chee-Wai Cheng, Li Zhao, Mark Wolanski, Qingya Zhao, Josuha James, Kate Dikeman, Michael Mills, Mei Li, Shiv P. Srivastava, Xing Qi Lu, Indra J. Das

Editorial

Focusing in on radiation induced brain injury
M. Kerry O’Banion
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic
Naomi Lomeli, Daniela A. Bota
Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma
David C. Binder, Erik Ladomersky, Alicia Lenzen, Lijie Zhai, Kristen L. Lauing, Sebastian D. Otto-Meyer, Rimas V. Lukas, Derek A. Wainwright
Gut microbes modulate host response to immune checkpoint inhibitor cancer immunotherapy
Kebin Liu, Chunwan Lu
New light on the pancreatic cyst conundrum
Nathan A. Berger

Original Article

A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Statistical strategies for microRNAseq batch effect reduction
Yan Guo, Shilin Zhao, Pei-Fang Su, Chung-I Li, Fei Ye, Charles R. Flynn, Yu Shyr
Defining functional changes in the brain caused by targeted stereotaxic radiosurgery
Vipan K. Parihar, Munjal M. Acharya, Dante E. Roa, Omar Bosch, Lori-Ann Christie, Charles L. Limoli
A chain reaction approach to modelling gene pathways
Gary C. Cheng, Dung-Tsa Chen, James J. Chen, Seng-jaw Soong, Coral Lamartiniere, Stephen Barnes
Oncolytic virus-mediated tumor radiosensitization in mice through DNA-PKcs-specific shRNA
Takashi Kon, Xiuwu Zhang, Qian Huang, Zhonghui Yang, Shanling Liu, Bin Yan, Fang Li, He Wang, Chuan-Yuan Li
Identification of cancer mechanisms through computational systems modeling
Zhen Qi, Eberhard O. Voit
Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases
Steven K. M. Lau, Xiao Zhao, Ruben Carmona, Erik Knipprath, Daniel R. Simpson, Sameer K. Nath, Gwe-Ya Kim, Jona A. Hattangadi, Clark C. Chen, Kevin T. Murphy
A recursively partitioned mixture model for clustering time-course gene expression data
Devin C. Koestler, Carmen J. Marsit, Brock C. Christensen, Karl T. Kelsey, E. Andres Houseman
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines
Amber M. Bates, Maria Paula Gomez Hernandez, Emily A. Lanzel, Fang Qian, Kim A. Brogden

Review Article

Integrative clustering methods for high-dimensional molecular data
Prabhakar Chalise, Devin C. Koestler, Milan Bimali, Qing Yu, Brooke L. Fridley
Sparse principal component analysis in cancer research
Ying-Lin Hsu, Po-Yu Huang, Dung-Tsa Chen
An improved understanding of cancer genomics through massively parallel sequencing
Jamie K. Teer
Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications
Louis Dubeau
Cancer biomarker discovery and validation
Nicolas Goossens, Shigeki Nakagawa, Xiaochen Sun, Yujin Hoshida
The promise and challenge of ovarian cancer models
Noor Hasan, Anders W. Ohman, Daniela M. Dinulescu

Perspective

Circular RNAs and competing endogenous RNA (ceRNA) networks
Apratim Mitra, Karl Pfeifer, Ki-Sun Park

Review Articles

New developments in treatment planning and verification of particle beam therapy
Reinhard W. Schulte, Andrew J. Wroe
Externally modulated theranostic nanoparticles
Cordula Urban, Alexander S. Urban, Heather Charron, Amit Joshi
Intestinal stem cell injury and protection during cancer therapy
Jian Yu
Cancer stem cells in glioma: challenges and opportunities
Jialiang Wang, Yufang Ma, Michael K. Cooper
Tumor microenvironment and nanotherapeutics
Meenakshi Upreti, Amar Jyoti, Pallavi Sethi
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury
Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou
Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis
Chang-Lung Lee, Jordan M. Blum, David G. Kirsch
DNA ligases as therapeutic targets
Alan E. Tomkinson, Timothy R.L. Howes, Nathaniel E. Wiest
DNA damage tolerance: a double-edged sword guarding the genome
Gargi Ghosal, Junjie Chen
DNA double strand break repair via non-homologous end-joining
Anthony J. Davis, David J. Chen
DNA crosslinking damage and cancer - a tale of friend and foe
Yaling Huang, Lei Li
Convergence of nanotechnology with radiation therapy—insights and implications for clinical translation
Dev Kumar Chatterjee, Tatiana Wolfe, Jihyoun Lee, Aaron P Brown, Pankaj Kumar Singh, Shanta Raj Bhattarai, Parmeswaran Diagaradjane, Sunil Krishnan
MDM2 and MDMX: alone and together in regulation of p53
Miriam Shadfan, Vanessa Lopez-Pajares, Zhi-Min Yuan
Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase
Lijian Shao, Lixian Wu, Daohong Zhou
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment
Feng-Ming Hsu, Shichuan Zhang, Benjamin P.C. Chen
SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis
Seong-Hoon Park, Yuming Zhu, Ozkan Ozden, Hyun-Seok Kim, Haiyan Jiang, Chu-Xia Deng, David Gius, Athanassios Vassilopoulos
Normal tissue protection for improving radiotherapy: where are the Gaps?
Pataje G.S. Prasanna, Helen B. Stone, Rosemary S. Wong, Jacek Capala, Eric J. Bernhard, Bhadrasain Vikram, C. N. Coleman
Improving chemoradiotherapy with nanoparticle therapeutics
Michael Joseph Eblan, Andrew Zhuang Wang
Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization
Jay F. Dorsey, Lova Sun, Daniel Y. Joh, Alon Witztum, Ajlan Al Zaki, Gary D. Kao, Michelle Alonso-Basanta, Stephen Avery, Andrew Tsourkas, Stephen M. Hahn
Molecular mechanisms involved in tumor repopulation after radiotherapy
Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li
Efficacy of combination treatment modalities for intermediate and advanced hepatocellular carcinoma: intra-arterial therapies, sorafenib and novel small molecules
Julio A. Gutierrez, Robert G. Gish

Original Articles

Third generation gold nanoplatform optimized for radiation therapy
Rajiv Kumar, Houari Korideck, Wilfred Ngwa, Ross I. Berbeco, G. Mike Makrigiorgos, Srinivas Sridhar
Utilizing signature-score to identify oncogenic pathways of cholangiocarcinoma
Tzu-Hung Hsiao, Hung-I Harry Chen, Jo-Yang Lu, Pei-Ying Lin, Charles Keller, Sarah Comerford, Gail E. Tomlinson, Yidong Chen

Research Highlights

A balancing act for breast cancer? Everolimus for hormone receptor positive patients
Stephanie B Wheeler, Katherine Reeder-Hayes, Anne-Marie Meyer

Below are the latest Translational Cancer Research articles published online ahead of print publication.

Original Article


Review Article


Case report


Letter to the Editor