Deletion of tumor progression locus two attenuates alcoholinduced

Alcoholic liver disease (ALD) is the predominant cause of liver-related morbidity and mortality. Inflammatory cytokines, such as tumor necrosis factor-α and interferon-γ, inducing liver injury and lead to the development of ALD. The clinical manifestations are nausea, vomiting and jaundice, also lead to liver enlargement and painful, meanwhile, can be complicated by liver failure and upper gastrointestinal bleeding. Alcoholic hepatitis has a high independent risk of death more than inactive cirrhosis.