Guest Editor (Figure 1):
Zhi-Min Yuan, MD, PhDDepartment of Genetics and Complex Diseases, Harvard University School of Public Health, Boston, MA, USA.
In this volume, the reader can find papers describing mechanisms of post-transcriptional and post-translational control of p53 and its regulators MDM2 and MDMX, its interaction with other pathways, like the mTORC1 pathway, and its role not only in cancer but also in aging and inflammation.
We start off with a review by Chen, discussing the function of disordered regions and describing their dynamic intra molecular interactions with the structured domains regulating p53 DNA binding and MDM2 ubiquitin E3 ligase activity. The author provides new insight on how p53 is controlled by stress signals, and suggests potential targets for the search of allosteric regulators of the p53 pathway.